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Showing 1 to 18 of 18 for “"coagulopathy"”.
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Identification of Multiple Levels of Trauma Induced Coagulopathy
… for an in-depth assessment of trauma-induced coagulopathy led to the development of a swine based model of hemorrhagic shock. In this model a composite injury consisting of soft tissue damage, long bone fracture, and controlled hemorrhage was used to induce a moderate state of hypovolemic …
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Coagulopathy in severe, isolated traumatic brain injury: A prevalence study
… and long-term disability in young adults. Hypocoagulopathy is a well described sequela of severe TBI and is associated with prolonged intensive care unit stays and poor outcomes. This study was conducted to determine the prevalence of coagulopathies in patients with severe, isolated TBI. The …
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Resonating Fluidic Circuits: A Novel Technology to Create a Portable Blood Viscoelasticity Measuring Device
The prehospital detection of coagulopathy has been identified as an important goal for the future of emergency medicine and trauma care. However, no clinically accepted devices that can diagnose coagulopathy by measuring blood clot viscoelasticity are portable, meaning that coagulopathy can only be …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… during the acute phase of trauma-induced coagulopathy. The development of microfluidics, microfabrication, and its applications in hemostasis and thrombosis is essential in advancing our knowledge of clinical and pathological disorders such as myocardial infracts, hemophilia, and deep vein …
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A Prospective, Descriptive Study Evaluating The Evolution Of Covid-19 Associated Coagulopathy In Mechanically Ventilated, Critically-Ill Patients Using Standard Laboratory Coagulation Studies And Thromboelastography
… Coronavirus disease 2019 (COVID-19) associated coagulopathy in critically-ill patients. We aimed to perform serial thromboelastography (TEG) and laboratory coagulation studies on critically-ill patients with COVID-19 over a 14-day period, comparing variables in 30-day survivors with those in …
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Spectrum of coagulation profiles in severely injured patients: A subgroup analysis from the FIRST ( Fluids in Resuscitation of Severe Trauma) trial
… civilian and military settings. Trauma induced coagulopathy (TIC) is now widely accepted as a major contributing factor to worsening bleeding in these patients. A quarter of severe trauma patients present with coagulopathy on admission and remain a group with high morbidity and mortality. …
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The impact of thromboelastography on patients with penetrating abdominal trauma requiring intensive care
Background Trauma induced coagulopathy is a complex multifaceted process which contributes to higher mortality rates in severely injured trauma patients. Thromboelastography (TEG) is an effective test to detect TIC which assists in instituting goal directed therapy as part of damage control …
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Outcomes and risk factors of very low birth weight infants with intraventricular haemorrhage who received respiratory support in a middle income country neonatal unit
… p=0.03). Severe IVH and the presence of coagulopathy were the strongest predictors of death in both ventilation groups (p <0.0001). Pulmonary haemorrhage was the commonest cause of death in those with severe IVH and blood culture confirmed sepsis in those with mild IVH. Periventricular …
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In-vitro Clot Formation and Failure
… severe injured patients display trauma induced coagulopathy (TIC) which is a multifactorial condition that causes poor clot formation and performance. A decreased level of viscoelastic clot stiffness or strength and rapid clot breakdown by enzymatic degradation are hallmarks of this condition. …
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The effects of hypothermia and acidosis on Haemostasis
… These patients are often investigated for coagulopathy, often as a result of bleeding. Traditionally routine coagulation screening is performed in buffered systems at 37°C. Therefore the information returned by the laboratory tells the clinician what the clotting will be like if the …
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Aspects of retransfusion of shed blood in cardiac surgery
… enhanced inflammatory response, hemolysis and coagulopathy. Emboli of various matters has also been studied. Whether they affect the function of various organs is an ongoing debate. Renal dysfunction after cardiac surgery is a well known complication. Monitoring of renal function is important, …
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Effect of a histidine-tryptophane-ketoglutarate solution on coagulation as measured by a thromboelastogram
… the study. The exclusion criteria were any known coagulopathy, liver diseases, alcoholism, kidney disease and intake of any drugs known to impair the coagulation. Ten millilitre of blood was drawn from the volunteer at the coagulation laboratory. The blood was diluted with either HTK solution or …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… levels were associated with trauma-induced coagulopathy, injury severity, and mortality, underscoring its relevance in thrombo-inflammatory platelet responses. These findings challenge conventional diagnostic paradigms and advocate for precision medicine approaches using integrated biomarker …
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Hyperinflammatory Experimental Cerebral Malaria: Coagulation and Glial Cell Activation in Plasmodium chabaudi Infection of IL-10-deficient Mice
… and low-molecular-weight heparin, on vascular coagulopathy and astrocyte activation in order to identify drivers of pathology in the brain parenchyma. Neutralization of TNF reduced mortality as previously reported, but also eliminated behavioral deficits, and significantly reduced both thrombus …
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Applications of blood biomarkers of traumatic brain injury across the severity spectrum---a focus on pathophysiological mechanisms
INTRODUCTION. Traumatic Brain Injury (TBI) is a global health concern. Spanning mild cognitive disturbances to unsurvivable trauma, the clinical challenges of TBI range from acute life-saving predicaments to the management of chronic cognitive impairment. While the primary insult leading to injury …
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THROMBUS GENERATION UNDER FLOW CONDITIONS IN PATIENTS WITH CIRRHOSIS AND THROMBOCYTOPENIA: THE CIRTAS-STUDY
Background: Thrombocytopenia is a hallmark of cirrhosis, however its effect on the bleeding risk remains uncertain due to a rebalance of hemostasis. Traditional coagulation tests, such as platelet count, prothrombin and activated thromboplastin time, fail to capture the complex interplay of pro- …
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Erstellung und Erprobung eines wissensbasierten Systems zur Unterstützung der Labordiagnostik der Thrombophilie
Bei der vorliegenden Arbeit wurde ein wissensbasiertes System für die Erstellung von Befundvorschlägen in der Thrombophilie-Diagnostik mit Hilfe der Notation Pro.M.D. erstellt.<br><br>Besonders bei der Gerinnungsdiagnostik ist es erforderlich, zielgerichtet und rationell weiterführende …