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Showing 1 to 19 of 19 for “"coagulation factors"”.
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Blood Coagulation Factors in the Goat
Made available in DSpace on 2014-12-11T21:33:46Z (GMT). No. of bitstreams: 1 7317492.pdf: 3950835 bytes, checksum: aac9b310e4a495269ac3a7fc504c0c6b (MD5) Previous issue date: 1973
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Comparisons among genetically diverse lines of chickens for blood coagulation factors
Blood coagulation time was determined in five genetically diverse lines of chickens by the capillary tube method. Significant differences were found among lines for coagulation time suggesting genetic influences on this characteristic in chickens. Heritability of blood coagulation as estimated by …
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The Effect of Acute Exercise on Coagulation Factors and the Mechanical Properties of Fibrin Fibers
… to investigate the effect of acute exercise on coagulation factors and fibrin fiber properties in both younger, healthy subjects and older, subjects with cardiovascular disease (CVD). In addition, it was of interest to examine relationships between coagulation factors and fibrin fiber properties …
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Assessing gene expression of coagulation factors and Factor XIII polymorphisms in type 2 diabetes mellitus patients
… of the study was to assess the mRNA levels of coagulation factors and the identification of two FXIII SNPs (Val34Leu and Tyr204Phe) in T2DM patients (n=100) compared to controls (n=100). Methodology: Thromboelastography (TEG) was used to assess the viscoelastic properties of pre-selected clot …
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Roles of coagulation factor XIII in the functions of blood platelets
… concerted actions of blood platelets and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their haemostatic roles (Marcus, 1969, Ruggeri and Mendolicchio, 2007). Coagulation factors are also …
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The Pathophysiology of Acute T-2 Mycotoxicosis in Swine (t-2 Toxin, Shock, Yellow Rain)
… of vasoactive substances, and plasma coagulation factors.
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Polyphosphate and tissue factor/factor VIIA as initiators of coagulation
… interactions are a critical component of the coagulation cascade. For many coagulation factors, these interactions are mediated via γ-carboxyglutamate rich regions, or GLA domains, in a Ca2+-dependent manner. Nearly all studies of GLA domain-containing coagulation factors, and coagulation in …
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Thrombotic fingerprints for the enhanced prediction of thrombosis
… pathways that govern activation of specific coagulation factors or platelet function, but they do not provide the insight into mechanism, risk and potential therapeutic benefit. We posit that elucidation of the complex dynamics of clot generation requires an integrated assessment that takes …
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Screening Of Natural Products For Their Effect On Kallikrein-Kinin System: Potential Implications In The Treatment Of Hereditary Angioedema
… cells and controls both the intrinsic blood coagulation and the alternative complement cascades. The uncontrolled activation of these cascades results in the development of pathological pain and angioedema. Increased plasma kallikrein levels are associated with hereditary angioedema (HAE) and …
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Biological Functions of ribonuclease 1 and angiogenin
… of these enzymes. Extracellular RNA drives blood coagulation, which is preventable by administration of RNase A. In Chapter 2, I demonstrate that loss of RNase 1, a nonspecific and extracellular ptRNase similar to RNase A, results in the potentiation of blood coagulation by activation of …
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Evaluation of the Role of Endogenous Factor XIII as a Determinant of Bleeding-Related Outcomes and Death Among Severely Injured Patients
… blood loss by reducing clot destruction with coagulation factors such as factor XIII (FXIII). Lower serum FXIII levels can cause reduced clot stability and premature clot breakdown. We hypothesize that lower FXIII levels result in worse bleeding-related outcomes and death. To test the …
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The Requirement for Viable Platelets in the Coagulation of Heparinized Blood
<p>Activated coagulation times (ACT's) of heparinized blood or plasma samples containing normal platelets were compared with ACT’s of heparinized samples containing non-viable or abnormally functional platelets. The non-viable platelets were prepared by freeze/thawing, and the abnormally functional …
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Recombinant Engineering Strategies for the Production of Therapeutic Coagulation Factor Proteins
Dysregulated coagulation is a common clinical condition secondary to one of numerous blood dyscrasias and can be restored by therapeutic intervention with agents rich in coagulation factor proteins such as whole blood, fresh frozen plasma, prothrombin complex concentrates, and single coagulation …
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Surface modification of traditional and bioresorbable metallic implant materials for improved biocompatibility
… induced comparable or lower levels of several coagulation factors compared with 316L stainless steel. Little platelet adhesion was observed on any of the tested materials. ^ Endothelialization is an important process after the implantation of a vascular stent, as it prevents damage to the …
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Structural studies of membrane-associated complexes by solid-state NMR
… (PS) complexes that regulate blood coagulation, and to understand how interactions of the antifungal drug amphotericin B with ergosterol are related to its toxicity. The enzymatic activity of blood coagulation proteins is critically dependent upon the exposure of phosphatidylserine …
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The tissue factor-factor VII(a) complex in blood coagulation
Initiation of the coagulation cascade in vivo is mediated by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… exposure which is hypothesized to alter the coagulation cascade. The conventional oral DES because of its first pass effect led to a high hepatic exposure and significant toxicities. Thus, our aim was to develop a subcutaneous sustained release nanosuspension formulation of DES, which would …
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The Effect of a 20-25 calories % Fat Diet on Plasma Thromboxane B₂ Levels in Human Subjects
<p>Fourteen males with elevated blood lipids were given a 20-2.5 Calories % fat diet for 28 days. Fasting blood samples were drawn at zero, two, and four weeks and analyzed for plasma TXB₂ and serum lipids. Plasma TXB₂ was significantly increased the first two weeks with a subsequent decrease the …