Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"coagulation cascade"”.
-
Simulating atomic-level interactions in the coagulation cascade
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
-
Polyphosphate is a novel modulator of coagulation and inflammation and is a therapeutic target
… and reactions that make up the traditional blood coagulation cascade has been understood for many years, appreciation of the complexity of these interactions has greatly increased in recent times. This has resulted in unofficial “revisions” of the coagulation cascade to include new amplification …
-
Variazione dei markers di attivata coagulazione indotta dalla terapia infusionale con Infliximab in pazienti affetti da malattie infiammatorie croniche intestinali
… A relationship between inflammatory response and coagulation is suggested by many observations. In particular, pro-inflammatory cytokines, such as TNFalpha, promote the activation of coagulation and reduce the production of anticoagulant molecules. It is known that inflammatory bowel diseases show …
-
Engineering rFVIIa-loaded platelets; a novel approach to treating acute bleeding
… and, along with cross-linked fibrin from the coagulation cascade, are involved in forming a haemostatic plug upon exposure to damaged endothelium in a wound. They are metabolically active and undergo a process of platelet activation when stimulated by pro-thrombotic agonists such as thrombin …
-
ΜΕΛΕΤΗ ΠΑΡΑΛΛΑΓΩΝ ΚΑΙ ΕΛΕΓΧΟΣ ΦΟΡΕΩΝ ΑΙΜΟΡΡΟΦΙΛΙΑΣ Β ΣΤΗΝ ΕΛΛΑΔΑ
… BY REDUCED OR ABSENT SYNTHESIS OF FIX OF THE COAGULATION CASCADE. FIFTEEN FAMILIES CONSISTING OF 22 HAEMOPHILICS AND 61 RELATIVES WERE STUDIED. CARRIER DETECTION INASYMPTOMATIC FEMALE POSSIBLE CARRIERS WAS PERFORMED WITH CONVENTIONAL IMMUNOLOGICAL TECHNIQUES FOR EVALUATION OF THE PHENOTYPE AND …
-
Multiplex analysis of protein-lipid and protein-membrane protein interactions utilizing silicon photonic microring resonators
… protein-lipid interactions that govern the blood coagulation cascade. To accomplish this, nanodiscs were integrated with silicon photonic microring resonators. Nanodiscs are easy to assemble, nanometer scale lipid bilayer discs which offer a high degree of control over lipid and membrane …
-
Single Fibrin Fiber Mechanical Properties and Lysis
… and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, …
-
DISCOVERY AND BIOPHYSICAL CHARACTERIZATION OF ALLOSTERIC INHIBITORS OF FACTOR XIa (FXIa)
… of thrombosis usually target the enzymes of the coagulation cascade. FXIa, a 160 kDa homodimer is gaining popularity of late as a potential target for anti-thrombotic agents due to its relative safety. A number of inhibitors which target the active site of FXIa have been reported but to our …
-
Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation
… particularly in the simplification of the coagulation biochemistry. Explicit modelling of the coagulation cascade is replaced with a patient-specific thrombin generation curve. This curve is defined by three values obtained from a blood test. Another key feature is the thrombosis growth …
-
Efforts towards the synthesis of fully N-differentiated heparin-like glycosaminoglycans; and, Investigations into the mechanism of inactivation of RTPR by gemcitabine triphosphate
… and are an important component of the coagulation cascade. They have also been implicated in interactions with growth factors, cytokines, virus entry, and other functions. Currently, no general synthesis of arbitrary HLGAG sequences has been demonstrated. The modular synthesis of …
-
Choline Inhibition of Prothrombinase
… on the terminal enzymatic complex of the blood coagulation cascade. Reports in the literature have indicated that choline lengthens whole plasma clotting time with a likely site of inhibition being the step that converts prothrombin (II) to thrombin (IIa).</p> <p>In order to quantitate the …
-
Determination of ADAMTS13 Susceptibility in Type IIA von Willebrand Disease
… (vWF), a large glycoprotein that assists in coagulation. Specifically, large vWF multimers in the blood stream are key components in starting the coagulation cascade. vWF is cleaved by the metalloprotease ADAMTS13, regulating the multimers size, which hinders vWF’s ability to function …
-
DNA Methylation Landscape of the Fibrinogen Gene Cluster in the Equine Embryo
… a protein best known for its involvement in the coagulation cascade and wound repair. The aim of this MSc project was to contribute to the characterization of conceptus-derived fibrinogen at the time of fixation. We confirmed early embryo expression in the absence of hepatic activity, as well as …
-
Synthesis and biological evaluation of aeruginosin based compounds and self-assembly of glucosamine based compounds
… are inhibitors for enzymes involved in the blood coagulation cascade, such as thrombin and Factor VIIa. In order to understand the structure activity relationship (SAR) of the aeruginosins and to discover novel anticoagulants with potentially improved inhibitory and pharmacokinetic properties, in …
-
Incorporation of Tetracycline Hydrochloride into Electrospun Fibrinogen: a study of mechanical properties and time release
… the benefit of existing as part of the natural coagulation cascade. Mats of fibrinogen could be utilized as possible hemostatic dressings or as an early scaffold for cell migration for either wound repair or tissue engineering. The addition of antibiotic into such a dressing/scaffold could …
-
Improving Biocompatibility By Controlling Protein Adsorption: Modification And Design Of Biomaterials Using Poly(Ethylene Glycol) Microgels And Microspheres
… of specific enzymes initiates the coagulation cascade on hydrophilic surfaces. The objective of this thesis is to improve the design of biomaterials through the analysis and control of adsorbing protein layers. This goal is approached through three separate strategies. First, a …
-
Designing Allosteric Inhibitors of Thrombin
Thrombin is a key enzyme of the coagulation cascade exhibiting important roles in both pro-coagulation and anti-coagulation processes. Most clinically used anticoagulant drugs, including polymeric heparin, warfarin, hirudin, argatroban and the recently approved dabigatran, aim to reduce thrombin …
-
The tissue factor-factor VII(a) complex in blood coagulation
Initiation of the coagulation cascade in vivo is mediated by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the …
-
A Glomerular Basement Membrane-on-a-Chip Model for Investigating Charge-Selective Transport Across the Human Filtration Barrier
… blood–membrane interactions activate the coagulation cascade and complement system, leading to protein adsorption on the membrane surface, impaired filtration, and adverse patient outcomes. This underscores the need for biocompatible membranes that better replicate the functional …
Page 1 of 3