Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"co-stimulatory molecules"”.
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Studies on the molecular mechanism of T cell triggering and detection and characterization of antigen-specific T cells
(cont.) Identification and characterization of T cell epitopes derived from infectious agents or vaccines can greatly enhance the ability to study and eventually direct the immune response. This work contains a description of a novel technique for identifying and characterizing specific T cell …
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Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
… cells (APC) by expressing class II major histocompatibility complex (MHC) antigens and co-stimulatory molecules upon activation. In vitro, astrocytes are activated by lipopolysaccharides (LPS), and interferon-gamma (IFN-gamma). We previously reported that gangliosides, membrane components of …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
… is also known to up-regulate immune inhibitory molecules in the tumor micro-environment. To further investigate the effects of IL-1 in melanoma progression, IL-1α was blocked in a highly aggressive pre-clinical B16 melanoma tumor model in three different treatment settings: as a monotherapy, in …
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땅콩에 감작된 생쥐 비장에서 분리된 수지상세포의 감마선 조사 땅콩 단백 자극에 대한 사이토카인 발현 양상
… 10)으로 자극하였다. 자극된 수지상 세포의 IL-10, IL-12 사이토카인의 발현과 co-stimulatory molecules 발현 양상을 확인하여 감마선이 조사된 땅콩 단백 추출물이 알레르기 반응을 감소시키는 효과가 있는지 확인하고자 한다. 본 실험은 BALB/c와 C57BL/6 4주령의 웅성 생쥐 12마리를 각각 6마리씩 땅콩에 감작시켜 진행하였다. 생쥐는 1주 간격으로 총 5주 동안 땅콩 단백 100 ㎍과 항원보조제인 aliminum hydroxide 1㎎을 혼합하여 피하 주사하였으며, 감작시키는 동안 매주 생쥐의 …
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Immunisierung gegen das Tumorantigen CEA: Vergleichende Untersuchung an Wildtyp- und CEA transgenen Mäusen
Immunization protocols in animal models have shown that the tumor-associated antigen CEA could be a target for active immunization. Since human CEA which does not exist in the rodent genome has been used in these models it is hard to decide whether part of the immune response is directed only to …
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Imaging innate immune cell behaviour in lymphoid organs
… immune cells, for example via major histocompatibility complex class II (MHCII) expression for antigen presentation. Secondary lymphoid organs, including lymph nodes (LNs) and Peyer’s patches, are ideal sites for innate-adaptive cellular interactions. Whilst neutrophils migrate to LNs …
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… and orchestrate T cell immune responses, comprise a heterogeneous group of cells. For example, in the steady state, murine spleen contains pre-DC-derived CD8+DEC-205+ and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation in vivo, antigens were specifically …
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Multiple sclerosis associated SNPs influencing B cell expression of co-stimulatory receptors and T cell responses
… of the central nervous system (CNS) which has a complex aetiology that involves the interplay of both genetic and environmental factors. Although more than 200 susceptibility loci have been identified through genome-wide association studies, our understanding of the molecular mechanisms …
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Determining stromal evolution in response to immune checkpoint inhibition
Directing the immune system to recognise and eliminate developing tumours has been hypothesised for over a century, yet only recently has this concept translated to the clinic with the discovery of immune checkpoint inhibitors (ICIs) which reactivate anti-tumour T cells. However, their rapid …
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Astrocytes modulate microglial phenotype and dendritic cell-like properties
… CNS, they express negligible levels of MHC II molecules as well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in isolated microglia in vitro by sequential treatment with …
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The immunogenicity of embryonic stem cell-derived midbrain dopaminergic progenitors and its implications as a therapy to treat patients with Parkinson’s Disease
… the surface expression of several major immune molecules on these progenitors under normal and inflammatory conditions, given the latter would be the environment post-transplant. MHC-I expression was low in mDAps but was upregulated in inflammatory conditions; MHC-II and the co-stimulatory …
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Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation
… DCs are distributed throughout the lungs in the conducting airways of the tracheobronchial tree and in the parenchymal lung, and play a pivotal role in controlling the immune response to inhaled antigens. The respiratory surface is continually exposed to potentially injurious particulates and …
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Development of polymeric nanoparticle vaccines for immunostimulation
… immunity, yet vaccine development has progressed comparatively slowly. This thesis serves to explore two polymeric nanoparticle platforms to demonstrate the therapeutic potential of synthetic nanocarriers as vaccines with the aim of 1) providing greater spatiotemporal release of small molecule …
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Immune modulating functions by soypeptide lunasin in cancer immunotherapy
… the disease. Immunosurveillance is capable of recognizing and eliminating continuously arising transformed mutant cells, and thus cancer immunotherapy is one of the emerging therapeutic strategies that harnesses the power of the immune system to eradicate chemotherapy-resistant cancerous cells. …
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Targeting An Ancient Retrovirus During Melanoma Using Adoptive T Cells Therapy
… have a poor prognosis due to resistance to conventional therapies. Thus, new targeted treatment strategies are required to improve therapeutic outcome. One prospective approach is to infuse T cells that are rendered specific for tumor-associated antigens (TAAs) preferentially expressed on …
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Identification of candidate tumour antigen peptides with immunogenic potential for use in cancer immunotherapy
… the formation of memory T cells. CD4+ T cells recognise antigen in the context of peptide presented on MHC class II molecules, therefore recent research has focused on the identification of these peptides in order to formulate more effective immunotherapeutic strategies. As such, the aim of this …
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Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia
… is over-expressed on leukemic stem cells (LSCs) compared to normal hematopoietic stem cells and thus targeting this tumor- associated antigen (TAA) provides the potential to prevent relapse. The prototyical chimeric antigen receptor (CAR) is fashioned by combining the variable light (V …
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Intestinal macrophages in health and inflammation
The healthy large intestinal mucosa contains a vast pool of macrophages (mφ) that are close to the local bacterial flora and have several unique phenotypic and functional properties compared with other mφ populations. Although human colonic mφ retain some of the hallmark functions of mφ, such as …
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TLR1 I602S: trafficking dynamics and roles in resistance to mycobacterial infection
… mechanisms required for protection against constant exposure to potentially pathogenic microorganisms. Essential to this role is the ability to rapidly recognize the presence of foreign components or organisms indicative of infection. Toll-like receptors (TLR), a ten-member family of innate …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
Asthma is a chronic disorder of the conducting airways that involves the interplay of multiple genetic and environmental factors. It is characterized by reversible airway obstruction, cellular infiltration, airway inflammation and airway remodeling. Dendritic cells (DCs) are professional antigen …