Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"co-regulation"”.
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Understanding factors that affect gene co-regulation patterns
… with behavior disorders and immune system can be complex and challenging. Gene expression and network analysis can help to elucidate the main molecules and pathways that influence complex traits. The goal of these studies is to understand factors that affect gene co-regulation patterns related to …
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Co-regulation of advertising in the United Kingdom: regulators as corporate bodies and the effect on citizen empowerment
… of this thesis is a regulatory innovation termed co-regulation: a mode of regulation that includes formal involvement of both state and non-state actors. Its emergence and development is the result of two broad and significant changes in the nature of the statehood: the emergence of the regulatory …
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Developing bioinformatic tools for phosphorylation site co-regulation and correlation: The plant Cellulose Synthase Complex as a case study
… ranging from textiles to biofuel production. Regulation and polymerization of cellulose in plant cell walls are complex pathways consisting of many proteins with phosphorylated residues discovered through phosphoproteomic surveys. As a ubiquitous form of post-translational modification, …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
… of vascular smooth muscle cells (VSMCs) from a contractile /differentiated state to a synthetic/ proliferative state is a hallmark of many cardiovascular diseases, driven in part by extensive alternative splicing (AS) regulation. RBPMS, a master splicing regulator in differentiated VSMCs, is …
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Corporate Governance as a Transformation Tool in Sustaining Nigeria’s Small and Medium-Sized Enterprises (SMEs)
… and lack of access to capital as the significant contributory factors to the constraints the companies face. In addressing the issues of low managerial skills and lack of access to capital, this thesis examines the causal reasons for low managerial skills, and lack of access to capital as well as, …
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Methods for the estimation and application of biological networks
… example cancer and healthy cells. We describe a convex penalized likelihood equation whose solution has desirable properties for joint network estimation, and we detail an algorithm for its solution. The second method is a test for biologically meaningful changes in the pattern of co-regulation …
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Interactions of the sterol and lipid biosynthetic pathways in yeast
… Stamm erhöhte in beiden Fällen, aufgrund der Co-Regulation der Gene ACC1 und HMG1, den Gehalt an Sterolen. Jedoch verringerte sich der Fettsäuregehalt im HMG-deregulierten Stamm, wohingegen es im Wildtypstamm umgekehrt war. Im Squalen-überproduzierenden Stamm könnte das Gen HMG1 eher als das …
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Molecular analysis of La Crosse virus transcription and replication in host cells
… were observed on LAC mRNA. Sequence A comprised 66.0% of sequences observed and sequence B comprised 5.2% of sequences observed. Also, 19.0% of sequences were unique and heterogeneous. The sequences of caps scavenged by snowshoe hare (SSH) and Tahyna (TAH) viruses and various LAC virus …
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Elucidating the regulation of the Yeast Metabolic Cycle through the integration of gene expression and chromatin status
The Yeast Metabolic Cycle (YMC) has become a model to study how changes in the metabolic landscape can affect the chromatin status to regulate gene expression. Previous studies have shown how the YMC is divided in three main phases and have described the effect of certain histone modifications in …
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Effects of Facial and Vocal Emotion on Word Recognition in 11-to-13-month-old infants
The speech commonly addressed to infants (infant-directed speech or IDS) is believed to have multiple functions, including communication of emotion and highlighting linguistic aspects of speech. However, these two functions are most often studied separately so that the influence of emotional …
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Psychologists’ experiences of supporting the socio-emotional development of children through bibliotherapy
… development within the South African context. Although bibliotherapy is increasingly recognised as a developmentally appropriate and cost-effective intervention, little research has examined its use by registered psychologists. Guided by Erikson’s psychosocial theory, attachment …
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Desiccation-driven senescence in the resurrection plant Xerophyta schlechteri (Baker) N.L. Menezes
… metabolites and photosynthetic pigments and uncontrolled dismantling of cellular membranes and organelles. Angiosperm resurrection plants display vegetative desiccation tolerance and avoid drought-induced senescence in most of their tissues. Developmentally older tissues, however, fail to …
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Developing machine learning tools to understand transcriptional regulation in plants
Abiotic stresses constitute a major category of stresses that negatively impact plant growth and development. It is important to understand how plants cope with environmental stresses and reprogram gene responses which in turn confers stress tolerance. Recent advances of genomic technologies have …
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Molecular biology of B vitamin metabolism genes and their regulation in Phaeodactylum tricornutum
… B1) in its diphosphate form is an essential cofactor for virtually all organisms. Thiamine biosynthesis is an expensive metabolic process involving suicidal and low-turnover enzymes, and many organisms have lost the ability to synthesise thiamine and depend on an exogenous source. Those …
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Transcriptional and Post-Translational Mechanisms Contribute to Maintenance of Rest In Neural Tumors
… in neural progenitors by binding to its consensus <em>RE-1</em> element(s) located in the regulatory region of its target neuronal differentiation genes. The developmentally coordinated down-regulation of REST mRNA and protein in neural progenitors triggers terminal neurogenesis.</p> …
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Trim28 Interacts With Ezh2 to Regulate Its Activity
<p>In this dissertation, I discovered that TRIM28 interacts with EZH2 and regulates its activity in breast cancer cells. EZH2, the major H3K27 tri-methyltransferase, is over expressed in multiple subtypes of breast cancer; however, whether EZH2 plays an active role in breast cancer progression or …
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Model-Based Genomic/Proteomic Signal Processing in Cancer Diagnosis and Prediction
… for the early prediction of cancer. The concept of dependence network is proposed based on the dependence model. The interactions and co-regulation relationships among genes or proteins are modeled by the dependence network, from which we are able to reliably identify biomarkers, …
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Intestinal absorption barriers as modelled by p-glycoprotein and cytochrome p450 a34 in caco2 cells
… number and origin of two populations of Caco-2 cells influence their enterocyte-like characteristics. Caco-2 cells of passage number >90 from Novartis pharmaceutical company possess higher levels of expression of alkaline phosphatase and P-glycoprotein and a greater cellular uptake of …
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New Pleiotropic Co-Regulators of Gas Vesicle and Secondary Metabolite Production in Serratia sp. ATCC39006
… environments. S39006 also produces various secondary metabolites, including the tripyrrole red-pigmented antibiotic, 2‐methyl‐3‐pentyl‐6‐methoxyprodigiosin (prodigiosin; a prodiginine) and the β-lactam antibiotic, 1-carbapen-2-em-3-carboxylic acid (a carbapenem). The production and regulation …
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