Global ETD Search

Using genotypic and phenotypic methods to determine the HIV co-receptor phenotype in the clinical setting

Low, Andrew JohnUniversity of British Columbia2007

… people worldwide. It uses one of two main co-receptors to infect cells. The primary objective of this thesis is to evaluate genotypic and phenotypic assays for co-receptor usage in the clinical setting and investigate approaches for improvement of these assays. Methods: The concordance of …

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Genetic characterization of human immunodeficiency virus from Northern South Africa

Iweriebor, Benson Chuks2012

… 70 years ago it has diversified rapidly now comprising a number of different subtypes and circulating recombinant forms (CRFs). Currently, strains belonging to the same subtype can differ by up to 20% in their envelope gene, and between subtype distances can soar to 35%. Moreover this …

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Generation of a neutralization-resistant CCR5 tropic SHIV-MK38 molecular clone, a derivative of SHIV-89.6

Ishida, YukiKyoto University2016

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Diversity in APOBEC3 and CCR5 host genes and HIV-1 in a South African population

Matume, Nontokozo D.2018

Introduction Human Immunodeficiency Virus (HIV-1) continues to be a global public health concern, even though Antiretroviral drugs (ARV), especially Highly Active Antiretroviral Therapy (HAART) has significantly reduced morbidity and mortality due to AIDS globally in developed and developing …

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