Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"co-factors"”.
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Peanut allergy: a prospective study of thresholds, co-factors, mediators and severity
Peanut allergy is a public health concern which affects a significant proportion of the population. Accidental exposure to peanut can cause severe and fatal reactions in peanut allergic individuals and currently their only safeguard is to practise careful avoidance. Identification and protection of …
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Identification of native co-factors of MshB and MCA from Mycobacterium species
Mycothiol (MSH), a low-molecular- weight thiol, is a primary reducing agent and essential for the survival of mycobacteria. The full pathway of MSH biosynthesis and detoxification includes various promising drug targets. Several metalloenzymes are involved in this pathway, such as a deacetylase …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… in vertebrates. DD domain dimerization of CLIM (cofactor of LIM-HDs) can activate LIM-HDs and downstream gene transcription while over-expression of dominant-negative CLIM (DN-CLIM), which lacks the DD domain, blocks LIM-HD activity. Motor neurons fluoresce in HB9:GFP transgenic zebrafish as the …
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Untersuchungen zur Regulation der Flavonoidbiosynthese im Kulturapfel Malus x domestica
In contrast to many other plants where biosynthesis of flavonoids and regulation of the involved genes is well analyzed, only little is known in the cultured apple M. x domestica about this pathway. Although most important intermediates and their structural genes are identified, regulation and the …
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Topology and geometry-based methods for quantifying the complexity of protein structures
… dissertation we employ tools from knot theory in combination with available experimental data and molecular simulations to analyze the topological complexity of tau proteins. These proteins are involved in a class of neurodegenerative diseases, called tauopathies. The methods developed in this …
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Preparation of a self-contained NADH co-factor recycling particle system
… industries. Oxidoreductases require the use of co-factors. These small molecules are relatively expensive and are required in stoichiometric amounts for their enzymatic reaction; this negatively impacts the economic viability of their potential applications. Several methods have been developed …
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The Role of Initiation Factor Dynamics in Translation Initiation
… and a critical site for translational control of gene expression. Throughout all stages of protein synthesis, the ribosome is aided by essential protein co-factors known as translation factors. I have studied the role that two translation initiation factors, IF1 and IF3, play in the …
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Evoking presence through creative practice on Pepper's ghost displays.
… for the analysis of presence research in the context of Pepper’s ghost. Pepper’s ghost as a media platform offers new possibilities for performances, real-time communication and media art. The thesis gives an overview on the 150 year old history, as well as contemporary art creation on …
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Whole genome regulatory variant evaluation for transcription factor binding
… variants that are associated with disease and complex traits. Many of these variants reside in the non-coding region of the genome, and affect gene expression and downstream cellular phenotype by disrupting the regulatory machinery of the cell. For example these variants can alter the binding …
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A functional analysis of the epigenetic regulator CTCF
The highly conserved protein CTCF (CCCTC-binding factor) participates in many epigenetic regulatory functions, including insulation, imprinting, X chromosome inactivation, and both transcriptional activation and repression. Recent data has also suggested a prominent role for CTCF in mediating …
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Propagation from meteorological drought to agricultural drought under climate change
… be triggered depending on a number of catalytic co-factors. In this study we use satellite observations to quantify how coincident warm temperature anomalies makes the transition from one drought type to another to occur more frequently. We then show that climate model historical simulations …
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Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
… in diseases such as cancers, leading to uncontrolled growth and malignancy. At the crossroads of fate-switching, pioneer factors are a class of transcription factors equipped to bind cognate motifs in closed chromatin. Once they access the closed chromatin, pioneer factors can either act as …
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Regulation des DNA-Polymerase-[alpha]-Gens durch den Transkriptionsfaktor YB-1
… regulatory sequences of cell-cycle related genes contain putative binding sites. In the present study the DNA polymerase Alpha (DPA) gene is identified as another YB-1 responsive gene with a Y-box and 3‘ inverted repeat sequence, designated DPA RE-1, in the serum-responsive promoter region. …
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Regulators of <i>repo</i>: A Search for <i>gcm/repo</i> Transcription Factors
… al., 1995; Soustell et al., 2004). The varied outcomes of gcm expression imply the interaction of co-factors capable of giving the Gcm protein different "meanings" in different developmental contexts. The Gcm target repo is expressed exclusively in glial cells and its protein is essential for …
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The role of Cited2 in left-right patterning and placental development in the mouse
… of the CITED gene family of transcriptional co-factors widely expressed in the mouse conceptus. It interacts with various transcriptional factors to drive the proper development of many organs in the mouse. Territories of Cited2 expression in the mouse coincide with the tissues most affected …
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Investigating the role of mRNA capping enzyme in C-MYC function
… protein have had limited success, enzymatic co-factors or effectors of C-MYC present attractive alternatives for therapeutic intervention of C-MYC-driven cancers. mRNA capping enzyme (CE) initiates mRNA cap formation by catalysing the linkage of inverted guanosine via a triphosphate bridge to …
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Mapping Domains for ZIC3 Molecular Function
The zinc finger of the cerebellum (Zic) genes encode a family of transcriptional regulators critical for early embryogenesis. All ZIC proteins contain a zinc finger domain (ZFD) and other evolutionary conserved regions. They are pleiotropic in nature since they can influence gene expression …
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Mapping Domains for ZIC3 Molecular Function
The zinc finger of the cerebellum (Zic) genes encode a family of transcriptional regulators critical for early embryogenesis. All ZIC proteins contain a zinc finger domain (ZFD) and other evolutionary conserved regions. They are pleiotropic in nature since they can influence gene expression …
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Contribution of Lsh to DNA methylation reprogramming in embryonic stem cell, epiblast stem cell and embryoid body model systems
… embryonic development, resulting in almost complete erasure of the mark after fertilisation of the zygote. Genome-wide patterns of DNA methylation are subsequently re-established in the implanting blastocyst by de novo DNA methyltransferases Dnmt3a and Dnmt3b along with their catalytically …
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Exploration of Chemical and Biochemical Mechanisms of Catalysis
… catalyze a wide range of chemical processes that control cellular signaling. One such enzyme is ERK2 which plays a role in the transmission of signals by catalyzing the phosphorylation of its substrates. The signaling pathway that it is a part of is important in the control of growth, cell …
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