Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 122 for “"co-cultures"”.
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Biodegradation of polycyclic aromatic hydrocarbons : application of fungal-bacterial co-cultures and surfactants
… source, and, in addition, totally degrade these compounds to carbon dioxide and water.
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Development of microfluidic systems for studying functional connectivity between in vitro neuronal co-cultures
… machine that is fundamental to our existence as conscious individuals. This is highlighted during neurological disorders that can have a devastating impact on the sufferer's aptitude and quality of life. There is much which is not yet understood about what bhappens during neurological disorders …
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Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses
… neurologic sequelae such as behavioral changes, cognitive deficits, seizures, paralysis, or persistent infection. Relatively little is known about viral infections of cells within the central nervous system such as neurons and astrocytes. One challenge in studying central nervous system infection …
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An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing
… prominent in dark-skinned individuals and could result in serious psychosocial consequences such as low self-esteem, stigmatisation and discrimination among sufferers. Methods aimed at investigating rapid and efficient repigmentation in wounded skin are therefore pertinent. The aims of this …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
… steps in myelin formation. Schwann cell/neuronal co-cultures were used to study myelin synthesis in the peripheral nervous system. Progesterone and glucocorticoids were found to increase the rate of myelin synthesis in a dose-dependent manner. Both steroids increased the expression levels of …
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Development and Application of a Microfluidic Cultivation Platform for the Analysis and Control of Industrially Relevant Synthetic Microbial Co-Cultures
… research and biotechnological use of microbial co-cultures has been of great interest for several years, as they offer advantages over the frequently used monocultures and open up new application opportunities. Especially interactions based on synthrophy and commensalism, i.e. mutual or …
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Control of flow and oxygen in a 3-D perfused micro-environment fosters balanced survival of hepatocyte-non-parenchymal cell co-cultures
… flow and oxygen gradients close to physiological conditions would preserve the delicate balance between the cell types. Spheroids containing hepatoctyes with incorporated non-parenchymal cells (NPCs) were seeded into capillary bed sized channels in polycarbonate scaffolds, housed in a …
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Modulation of human adipose-derived stem cells and dermal fibroblasts in co-cultures by activation of the IL-6 trans-signalling pathway via the soluble IL-6Rα receptor
… pathway under four different cell culture conditions. The two cell types were co-cultured to assess cell migration when pre-treated with the soluble human IL-6Rα receptor (rhIL-6Rα). In addition, secreted cytokine levels (TGFβ1, TGFβ3 and VEGF) and biomarker expression (TGF β1RII, SMAD2/3, …
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Identification and Characterization of Distinct Populations of Clonogenic Bone Marrow Stromal Cells Capable of Transferring The Hematopoietic Microenvironment In Vivo and Supporting Lt-Hscs In Vitro
… for non-hematopoietic tissues (MSC) and 2) as components of the hematopoietic stem cell niche. Current approaches studying the stromal cell system in the mouse are complicated by the low yield of clonogenic progenitors (CFU-F). Given the perivascular location of MSC in BM, we developed an …
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The use of cultured cells with defects of citrulline metabolism in diagnosis and in the study of intercellular communication
… are two disorders resulting from defects in two consecutive enzymes of the urea cycle, argininosuccinate synthetase and argininosuccinate lyase. Fibroblast cell lines were derived from patients with these disorders and the diagnoses, which had been made on the basis of amino acid levels in plasma …
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Tissue engineering the anterior cruciate ligament : a regenerative medicine approach in orthopaedic surgery
… However, these approaches often lead to secondary medical problems, such as donor-site morbidity and immune rejection. Furthermore, in younger patients these grafts fail to grow, leading to additional complications and underlining the need for the development of new approaches that improve …
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Endothelial cell and mural progenitor cell co-culture to promote angiogenesis in tissue engineered constructs
… The ability to vascularize a tissue engineered construct is one of the major hurdles for tissue engineering because it can take 2 weeks for an implanted construct to become vascularized. To produce prevascularized tissues, the cellular interactions that occur during vascular formation need to be …
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Characterization of short chain fatty acids in microbial cultures by DART-MS and GC-MS
<p>Colonic bacterial degradation of starch and other carbon sources produces short-chain fatty acids (SCFA) such as butyrate and lactate, which are important in human health and disease. Analysis of the results of mono- and co-cultures in in vitro systems has led to the conclusion that diverse …
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In-vitro Modelling of Stromal and Immune Cell Interactions Following Surgical Bone Marrow Stimulation
… result in the formation of a haematoma containing Bone Marrow Stromal Cells (BMSC) and immune cells at the joint surface, leading to repair. However, the quality of repair after marrow stimulation is, at present, sub-optimal. BMSC are known to interact with immune subpopulations during …
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The role of neuron-microglial interactions in Ataxia-Telangiectasia
… neuron-microglial interactions and how it might contribute to cerebellar neurodegeneration in ATM deficiency. This thesis aims to investigate the roles of ATM kinase in neuron-microglial interactions using co-cultures of human post-mitotic neurons and microglia-like cells. This work demonstrates …
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Fluorescence characterization of protein and lipid dynamics
… the formation of myelin in neuron Schwann cell co-cultures. Domain motion upon substrate binding was examined in adenylate kinase using fluorescence resonance energy transfer. The process of myelin formation was examined by observing the growth and composition of myelin using a fluorescent …
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The Design of Antimicrobial Detachable Thin Films for the Study of Hepatic Infections
… of antibiotics, drug-resistant pathogens are becoming more common. It is imperative to explore broad spectrum antimicrobial approaches. In this work, we modified collagen/hyaluronic acid polyelectrolyte multilayers (PEMs) with the natural antimicrobial peptide, LL-37 to study hepatic infections. …
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Melatonin-micronutrients Osteopenia Treatment Study (MOTS): A translational study assessing the effects of melatonin, strontium citrate, vitamin D3 and vitamin K2 on bone density, bone turnover markers and health-related quality of life in postmenopausal osteopenic women following a one-year double-blind randomized placebo-controlled trial and on osteoblast-osteoclast co-cultures
… purpose of this study was to assess if a novel combination of melatonin and three other natural bone-aiding micronutrients: strontium citrate, vitamins D<sub>3</sub> and K<sub>2</sub> (MSDK) could improve bone health by modulating the activity of osteoblasts and osteoclasts in favor of balanced …
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