Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"cmvIL-10"”.
-
Effect of cmvIL-10 on Exosome Production by Human Breast Cancer Cells
… usually from metastasis. Exosomes are 30-100nm vesicles produced by most cells which carry protein and RNA to cells in their microenvironment. The aim of this study is to investigate the impact of HCMV-infection of a secreted viral cytokine, cmvIL-10, on exosome production by highly …
-
HCMV Promotes Breast Cancer Metastasis: Impacts of CMVIL-10 in the Tumor Microenvironment
… by HCMV-infected cells is the viral cytokine cmvIL-10, which acts through the cellular IL-10 receptor to induce downstream cell signaling. In instances where HCMV-infected cells infiltrate the tumor microenvironment, the presence of cmvIL-10 in may initiate events that promote a more invasive …
-
The roles of human cytomegalovirus US27 gene product during virus infection
… CXCR4 in response to its natural ligand CXCL12. cmvIL-10, an ortholog of human IL-10, was also found to enhance CXCR4 signaling and act synergistically with US27. In both HCMV-infected and US27-transfected cells, exposure to cmvIL-10 increased calcium and migration responses to CXCR4 ligand …
-
Detection of HCMV viral IL-10 (vIL-10) in healthy blood donors
… infection, the full length transcript yields cmvIL-10, a potent immunosuppressive viral ortholog of human IL-10 (hIL-10). Alternative splicing of the UL111A transcript yields a truncated protein, LAcmvIL-10, which is expressed during both lytic and latent infection but with a limited range of …