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Showing 1 to 20 of 124 for “"clotting"”.
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Blood clotting inspired polymer physics
The blood clotting process is one of the human body's masterpieces in targeted molecular manipulation, as it requires the activation of the clotting cascade at a specific place and a specific time. Recent research in the biological sciences have discovered that one of the protein molecules involved …
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Control of blood clotting using gold nanorods
… developed a method to externally control blood clotting using gold nanoparticles. Gold nanorods (NRs) have unique size and shape-dependent optical properties that can be used for externally controlled release of biomolecules by laser excitation. Femtosecond pulsed laser irradiation at the NR …
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Clotting analysis of blood samples from intensive care unit patients.
… patients. Materials and Methods: Comparative clotting analysis was carried out on whole blood and plasma samples from twelve samples from intensive care unit patients. Nine haemophiliac samples and 14 healthy individual samples were used as controls. Several assays were used to assess …
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Changes in the clotting viscoelasticity caused by cardiopulmonary bypass (CPB) surgery
… due to acquired platelet dysfunction. Standard clotting tests to determine the cause of bleeding usually take between 25 and 60 minutes to get results. This time frame is not useful for deciding what type of treatment to give to a patient. More importantly, the standard clotting tests is they …
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Computational model of thrombosis in cerebral aneurysms for predicting clotting outcomes in flow diverter treated patient-derived geometries validated with novel PIV-based ln vitro clotting flow experiment
… Many thrombosis models include complicated clotting mechanisms, which can be computationally expensive, and present a challenge to comprehensively validate in vitro due in part to the complexity of adequately measuring the ongoing interaction between flow and clot-growth; a key factor in …
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Discovery Of Inactive E* Conformations In Thrombin And Other Vitamin K- Dependent Clotting Proteases
… proteases belonging to Vitamin K-dependent clotting factors is significantly affected by Na+ through an allosteric mechanism. Over the past 30 years, structural and biochemical studies revealed that Na+ enhances the enzymatic properties of these proteases from a low activity, E, to a high …
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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
<p>Cerebral amyloid angiopathy (CAA), where beta-amyloid (Aβ) deposits around cerebral blood vessels, is a major contributor of vascular dysfunction in Alzheimer's disease (AD) patients. However, the molecular mechanism underlying CAA formation and CAA-induced cerebrovascular pathologies, including …
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Contribution of different types of phospholipids in blood coagulation
… become activated and proper interaction of blood clotting proteins with membranes of activated platelets is essential for maintaining a balanced hemostasis. Hemophilia and thrombosis are the two extremes of an imbalanced hemostasis where patients with hemophilia suffer from severe bleeding and …
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Polyphosphate modulates hemostasis, thrombosis, and inflammation
… activator of the contact pathway of blood clotting. These studies also implicate polyP in contributing to thrombosis and consumptive coagulopathies accompanying bacterial sepsis. PolyP polymer lengths are known to vary substantially among different organisms and cell types, with shorter …
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Pulsatile Flow in Computational Modelling of Thrombosis in Cerebral Aneurysms
… release of thrombin, a chemical responsible for clotting activation, has been implemented. The output of this simulation is compared to the output of an otherwise identical simulation utilizing Particle-Image-Velocimetry (PIV) validated steady flow conditions, to determine whether clotting …
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ENHANCEMENT OF hFVIII ACTIVITY THROUGH LC MODIFICATIONS FOR GENE THERAPY OF HEMOPHILIA A
… coagulation activity. A comparison of the FVIII clotting activity to the amount of protein produced determined that hLC-K12 produced a 3.28 fold increase in specific activity over hLC in vitro. Similar in vitro results were observed when hLC-k12 was tested with the X5 heavy chain (X5HC), a heavy …
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Polymers and colloids in flows : from dynamics to self-healing
… A special motivation comes from the blood clotting process. Our blood is a complex uid made of polymeric proteins and colloid-like cells. Controlled by ow, a blood-clotting protein (the so-called von Willebrand factor or vWF) can change shapes from a compact structure to an extended …
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Lipoids and blood platelets with reference to blood coagulation and the hemorrhagic diseases
… Analysed components are studied in artificial clotting systems, especially a two-stage thrombin- forming system. Some 86 cases of bleeding disorders, 32 new born normal infants and their mothers, and many normal adult bloods have been analysed with respect to components of the clotting and …
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The Requirement for Viable Platelets in the Coagulation of Heparinized Blood
… platelet factor 3 (PF3) is sufficient to promote clotting of unheparinized blood, viable platelets, in addition, are required for clotting of heparinized blood. A possible hypothesis which explains these findings is as follows:</p> <p>In the unheparinized situation, coagulation factors are …
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Sulfatides mediate Disabled-2 membrane localization and stability during platelet aggregation
… attack and strokes,1 is triggered by localized clotting of the blood as the result of deregulated platelet aggregation. During the repair of vascular injury, clotting usually occurs when platelets adhere to each other at the site of vascular injury in order to stop bleeding.2 Distinct protein …
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Synthesizing a Heparin Mimic Material Derived from Cellulose Nanocrystals
To prevent clotting during dialysis, heparin is used to line the tubing which blood flows through. Unfortunately, many side effects arise from taking heparin, especially when it is used for an extended period of time. As such, long-term exposure for individuals undergoing dialysis every day is …
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A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
… thrombus formation, we also characterized clotting profiles of patient populations and recreated disease phenotypes. Through modifying our microfluidic clotting assay, we reduced the risk of contact activation during sample preparation and increased the dynamic range for drug testing. …
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Engineering rFVIIa-loaded platelets; a novel approach to treating acute bleeding
… as well as platelet transfusion and recombinant clotting factors such as rFVIIa. However, the use of recombinant clotting factors is limited due to cost and adverse side effects resulting from increased thrombosis, such as increased rate of myocardial infarction and cerebrovascular accidents. …
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Pathological and therapeutic investigations in tuberculosis: PART I PATHOLOGICAL INVESTIGATION - an investigation into hypersensitivity in tuberculosis as illustrated by the response of the skin, and of the leucocytes of the blood to tubérculin; PART II THERAPEUTIC INVESTIGATION - a clinical evaluation of the use of para-aminosalicylic acid in the treatment of pulmonary tuberculosis.
… of a tuberculous individual is accelerated (when clotting is prevented.) in vitro by the addition of tuberculin.
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Structured surfaces for hemocompatibility
… these natural defenses specific to blood is the clotting reaction. Any surface, implanted or external, that comes into contact with blood is considered an intruder, and the blood seeks to isolate the object by clotting on the foreign surface.
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