Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"clot lysis"”.
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Biochemical And Genetic Studies of Quebec Platelet Disorder
… if increased platelet uPA contributes to QPD clot lysis in vitro; 2) investigate whether QPD individuals have increased urinary uPA, as some individuals experience hematuria; and 3) map the genetic locus of QPD, and look for the putative mutation. Studies of clot lysis indicated that QPD …
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Use Of Focused Ultrasound For Transcranial Sonothrombolysis
… focused ultrasound (FUS) for sonothrombolysis is a new research field for ischemic stroke treatment. If shown to be effective, FUS sonothrombolysis could become a widely available treatment option for the majority of the stroke sufferers that do not qualify or do not have access to …
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Advancing sepsis treatment: synthesis and evaluation of multi-target drugs with antimicrobial, antioxidant and anticoagulant properties.
… JW10 exhibited 1.25 Trolox equivalent (TE). The clot lysis assay was performed to investigate the anticoagulant properties. Compounds JW1, JW4, JW9 and JW11 demonstrated the strongest fibrinolytic activity, achieving a 50% clot lysis time of 68-78 minutes compared to the control (Pooled Normal …
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A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade
… work has shown that thrombin activatable fibrinolysis inhibitor (TAFI) was unable to prolong lysis of purified clots in the presence of Lys-plasminogen (Lys-Pg), indicating a possible mechanism for fibrinolysis to circumvent prolongation mediated by activated TAFI (TAFIa). Therefore, the effects …
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Thrombelastographische Blutgerinnungsuntersuchungen gesunder Schweine unter Xenonmono- bzw. einer Kombinationsnarkose aus Xenon und den volatilen Inhalationsanästhetika Isofluran, Sevofluran, Halothan und Enfluran
… of the coagulation process from initiation of clotting to the final stages of clot lysis or retraction.Results: Xenon monoanaesthesia did not significantly alter any coagulation parameters. When isoflurane was introduced the aPTT showed a significant increase while fibrinogen concentratins …
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A Prospective, Descriptive Study Evaluating The Evolution Of Covid-19 Associated Coagulopathy In Mechanically Ventilated, Critically-Ill Patients Using Standard Laboratory Coagulation Studies And Thromboelastography
… of patients while 82.5% presented with absent clot lysis. The functional fibrinogen MA was also elevated above the upper limit of the reference range in 92.5% of patients. All patients had elevated D-dimer and fibrinogen levels, prolonged prothrombin times (PT), normal platelet counts and …
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Studies of Coagulation and Fibrinolysis
… Lastly, the kinetics of plasmin-mediated lysis of fibrin clots was investigated. The clot lysis by plasmin showed a low Km (1 to 2uM) suggesting zero-order kinetics. In contrast, the clot formation showed first-order kinetics. These results suggest that as the concentration of fibrinogen …
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Proteases of the neutrophil membrane represent an alternative fibrinolytic pathway to that mediated by plasmin
… role in the breakdown of fibrin. Fibrinolysis by elastase and cathepsin G, enzymes present within the azurophilic granules of the neutrophil, has previously been shown. Recent studies have demonstrated neutrophil-mediated fibrinogenolysis by a membrane-associated protease which suggests …
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Global fibrinolytic potential of black South Africans in the North West Province
… the coagulation cascade is activated and a blood clot forms. The function of this clot is to stop bleeding. However, it cannot remain in the vasculature indefinitely and has to be lysed again. The ability of the body to lyse clots can be measured with global fibrinolytic potential (GFP) assays and …