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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"clot formation"”.
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In-vitro Clot Formation and Failure
… after traumatic injury is failure of hemostatic clot formation at wound sites. After trauma, approximately 25-30% of severe injured patients display trauma induced coagulopathy (TIC) which is a multifactorial condition that causes poor clot formation and performance. A decreased level of …
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High performance lattice boltzmann method yield-stress calculations based on intravital images of clot formation in live mice
… and simulation provided critical yield stress information. To our knowledge, this is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of …
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Fibrinogen, platelet and factor XIII supplementation in cardiac surgery: In vitro and in vivo studies
… perioperative bleeding, but there is little information about its efficacy. The overall aim of this thesis project was to study the effects of fibrinogen, platelet and factor XIII concentrates on markers of hemostasis in blood samples from cardiac surgery patients. Methods: Increasing doses of …
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Clotting analysis of blood samples from intensive care unit patients.
… patients. Materials and Methods: Comparative clotting analysis was carried out on whole blood and plasma samples from twelve samples from intensive care unit patients. Nine haemophiliac samples and 14 healthy individual samples were used as controls. Several assays were used to assess …
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A platelet-mediated paradigm for the targeted delivery of microencapsulated, clot-augmenting biotherapeutics
… to sense and actuate targeted delivery of a clot-augmenting therapeutic to a site of vascular injury. In this system, platelets target microencapsulated drugs through their natural aggregation behavior in the clot formation process and then deliver the drug by physically rupturing the …
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A Mechano-Chemical Computational model of Deep Vein Thrombosis
Deep Vein Thrombosis (DVT) is the formation of a blood clot in a vein, usually in the body's lower extremities. If untreated, DVT can lead to pulmonary embolism (PE), heart attack and/or stroke, which can be fatal. According to literature, DVT affects 0.2% of people in developed countries and about …
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Self-Assembling Peptide Nanofibers RADA16 and IEIK13 for Rapid Hemostasis
… examining the effects on the activity of several clotting factors as well as effects on clot formation. While some effects on the activity of individual clotting factors were observed, in vitro testing using whole blood showed no significant differences in clot formation. Finally, we developed …
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RECYCLING OF WASTE BLOOD INTO FUNCTIONAL CARBON NANOPARTICLES
… dose-dependent anticoagulant effects, reducing clot formation with minimal impact on blood viscosity and low toxicity, indicating high biocompatibility. This work highlights the feasibility of transforming blood waste into valuable nanomaterials, proposing a sustainable solution for waste …
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Development and experimental validation of a novel arterial thrombosis-on-a-chip microfluidic device
… of coronary arteries by platelet-rich thrombi (clots). The development of new anti-platelet drugs to prevent myocardial infarction continues to be an active area of research and is dependent on accurately modelling the process of clot formation. Occlusive thrombi can be generated in vivo in a …
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Roles of coagulation factor XIII in the functions of blood platelets
… and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their haemostatic roles (Marcus, 1969, Ruggeri and Mendolicchio, 2007). Coagulation factors are also spatially activated at these sites …
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Thrombotic fingerprints for the enhanced prediction of thrombosis
… embolism, are all derived from unrestricted clotting. The frustrating aspects of these diseases lie not only in the difficulty of their timely diagnosis, but in the selection of appropriate therapy, titration of intervention, and identification of patients at risk. Assays like the INR, PTT, …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… Platelet dysfunction can lead to bleeding and/or clotting disorders but is challenging to diagnose clinically. This thesis focuses on immune thrombocytopenia (ITP), a disorder marked by immune-mediated platelet destruction and impaired thrombopoiesis. Patients with ITP display heterogeneous …
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Pulsatile Flow in Computational Modelling of Thrombosis in Cerebral Aneurysms
… is an acceptable approximation when considering clot formation within a flowing environment. To this end a pulsatile flow model has been created in ANSYS® Fluent, and a function from Ngoepe and Ventikos’s computational model that simulates the release of thrombin, a chemical responsible for …
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Fibrin Formation and Dissolution in the Progression of Amyloid-Beta Pathology in Alzheimer's Disease
… that Aβ binds to fibrinogen and alters fibrin clot formation. Clots formed in the presence of Aβ have an abnormal structure and are resistant to degradation by fibrinolytic enzymes. We also found that ApoE isoforms differentially affect the structure of the fibrin clot formed in the presence of …
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Engineering rFVIIa-loaded platelets; a novel approach to treating acute bleeding
… as well as platelet transfusion and recombinant clotting factors such as rFVIIa. However, the use of recombinant clotting factors is limited due to cost and adverse side effects resulting from increased thrombosis, such as increased rate of myocardial infarction and cerebrovascular accidents. …
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Computational Modeling And Simulation Of Thrombus Formation
… medical complication because excessive thrombus formation could lead to obstruction of blood vessels, resulting in tissue ischemia or death. This study is aimed to understand the cell-biology and biophysics, at the molecular level, of thrombosis in a blood vessel. We first review the biology …
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Aspects of bleeding complications and hemostasis at central line insertion and mild induced hypothermia
… and not by enhancing platelet function. Improved clotting parameters persisted between 1 and 4 hours after transfusion. Paper III demonstrated increased platelet aggregation and strengthened clot formation over time in out-of-hospital cardiac arrest patients treated with hypothermia. In patients …
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A comparative study of ROTEM-EXTEM results obtained from EDTA-treated whole blood samples and Sodium Citrate-treated whole blood samples in healthy volunteers
… groups following the manufacturer's guidelines. Clotting time (CT), clot formation time (CFT), alpha angle (α-angle) and maximum clot firmness (MCF) results were compared. Ionised calcium concentrations were measured on each sample before and after recalcification with CaCl2 to determine if there …
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Studies of Coagulation and Fibrinolysis
… the kinetics of plasmin-mediated lysis of fibrin clots was investigated. The clot lysis by plasmin showed a low Km (1 to 2uM) suggesting zero-order kinetics. In contrast, the clot formation showed first-order kinetics. These results suggest that as the concentration of fibrinogen increases, …
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A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
… forces on neutrophil activities during clot formation. We discovered that high interstitial hemodynamic forces (> 70 mmHg/mm-clot) can drive physically entrapped neutrophils to rapidly form neutrophil extracellular trap (NET) during sterile occlusive thrombosis, offering an explanation …
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