Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"clopidogrel"”.
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Comparing long-term antiplatelet strategies to prevent morbidity and mortality in patients with drug-eluting coronary stents
… several APT strategies composed of aspirin and clopidogrel, both as monotherapy and in various clinically plausible combinations. The base case examined a 65-year old person treated with a DES then continuous aspirin plus clopidogrel (Dual-Rx) for one year without complications. We considered …
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When working towards an optimised Carotid stenting procedure does patient, procedural and pharmacological selection impact on outcome.
… of adverse outcomes than cerebral events, and clopidogrel use at the time of stenting prevents adverse events. Recurrent stenosis of more than 50% also increases risk for recurrent stroke in the long term and therefore warrants a long term surveillance programmes in stented patients. It was …
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Improving outcomes in patients with coronary heart disease using national registers and platelet function testing
… different exposures and their outcomes (clopidogrel pre-treatment, 5 different anti-platelet protocols, ticagrelor pre-treatment and treatment delays to PCI). Two papers involved evaluation of interventions: platelet function testing in patients with clopidogrel and clinical evaluation of …
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Influencia de la hiperglucemia aguda sobre la agregación plaquetaria
… tratamiento con acido acetilsalicílico (AAS) y clopidogrel en el primer año tras un SCA. De forma prospectiva se seleccionaron 80 pacientes consecutivos tras SCA con los criterios especificados. Entre el 3º-12º mes tras el SCA, se les realizó estudio antropométrico, insulinemia basal, hemograma, …
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Novel Agonists and Antagonists of Platelet Receptors
… P2Y12 activation and that the P2Y12 inhibitor, clopidogrel, lost in efficiency. The P2Y12 receptor is also present on vascular smooth muscle cells (VSMC), promoting contractions. We initiated a comparative study on human and murine artery tissue to evaluate if any of the antiplatelet substances, …
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Doble antiagregación tras cirugía coronaria aislada
… quirúrgica, empleando ácido acetilsalicílico y clopidogrel, disminuye el cierre precoz de los injertos coronarios, reduciendo la morbimortalidad cardiovascular. 2.- El tratamiento con doble antiagregación no supondría un incremento significativo del riesgo de sufrir complicaciones hemorrágicas …
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An analysis of the impact of generic medicine reference pricing in a sector of the South African private healthcare insurance industry
… referenced priced categories (Desloratadine and Clopidogrel) and a population of approximately 100,000 were identified as being eligible for inclusion. An authorised generic was launched for Clopidogrel but not for Desloratadine. The implementation of generic reference pricing appears to have had …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… a combination therapy consisting of aspirin and clopidogrel. Aspirin inhibits cyclooxygenase 1 (COX 1) a crucial intermediate enzyme involved in thromboxane biosynthesis. Clopidogrel on the other hand antagonizes ADP receptor P2Y12. ADP is a weak platelet agonist stored in platelet dense granules …
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Genotype- versus phenotype-directed personalization of antiplatelet treatment in Koreans with coronary artery disease undergoing coronary stenting
… or patients without HOPR were given 75 mg clopidogrel daily. The primary endpoint was the percentage of patients with HOPR after 30 days of treatment. PRU decreased following both genotype- and phenotype-directed therapies (242±83 vs. 109±90, p<0.001 in the genotype-directed group; 216±74 …
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Biochemische und Molekularbiologische Charakterisierung der Wechselwirkungen zwischen Humanen Thrombozyten und Endothelzellen
… antithrombotischen Medikamente Ticlopidin und Clopidogrel, welche gezielt die ADP-induzierte Thrombozytenaktivierung hemmen, zu verfolgen und das Antwortverhalten von Patienten auf diese Medikamente zu messen. Mehrere Personen, bei denen Ticlopidin und Clopidogrel keine Wirkung zeigten, wurden …
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Evaluating Risk of Delayed Major Bleeding in Critically Ill Trauma Patients
… use of the antiplatelet agents aspirin and/or clopidogrel, presence of intracranial bleeding, higher injury severity scores, requirement of massive transfusion, and low pH values. Use of anticoagulant prophylaxis was not associated with delayed major bleeding. Conclusion: The rate of delayed …
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Avaliação da agregação plaquetária na predição de eventos cardiovasculares em pacientes submetidos a implante eletivo de stents coronarianos farmacológicos
… plaquetária com ácido acetil salicílico (AAS) e clopidogrel. Cerca de 4 a 40% dos pts são resistentes ao clopidogrel quando avaliados por testes de agregação plaquetária. O valor destes testes na predição de eventos cardiovasculares de longo prazo não está determinado. Da mesma forma, não há …
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Electrolyte-gated graphene field-effect transistors : modeling and applications
… thought responsible for the metabolism of clopidogrel, a widely prescribed antiplatelet medication. The graphene EGFETs, however, failed to sense an increase in DNA concentration. Further optimization of the PCR mix is required to ensure that increased DNA concentration lowers the PCR mix …
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Pharmakologie der ADP-Rezeptoren auf humanen Thrombozyten
Die Thienopyridine Ticlopidin und Clopidogrel sind seit mehreren Jahren im klinischen Einsatz als Thrombozytenaggregationshemmer zur Sekundärprophylaxe bei arteriosklerotischen Erkrankungen der Herzgefäße, zerebralen Gefäße sowie der peripheren Arterien. Trotz ihrer nachgewiesenen klinischen …
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Untersuchungen zur inter- und intraindividuellen Variabilität der enzymatischen Funktion von Cytochrom P450 CYP2B6
… Thiotepa und die Thrombozytenaggregationshemmer Clopidogrel und Ticlopidin wurde eine irreversible und potente Inhibition von CYP2B6 nachgewiesen, welche durch Hemmung der CYP2B6- Aktivität zu klinisch relevanten Arzneimittelinteraktionen mit Substraten dieses Enzyms führen kann. Als weitere …
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Economic Evaluation of a Point of Care Pharmacogenetic Test (CYP2C19) from an Ontario Perspective
… a fully functional allele could be treated with clopidogrel while prasugrel or ticagrelor could be prescribed to patients with a loss of function allele. Pharmacogenetic (PGx) testing could optimize pharmacotherapy (i.e. fewer adverse event rates with PGx option, where results are available in 1 …
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CHEMOENZYMATIC APPROACHES TO THE PREPARATION OF BIOLOGICALLY ACTIVE COMPOUNDS
… compounds. The second topic regards the clopidogrel, a thienopyridine compound that inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled ADP receptors. It is indicated for the reduction of atherosclerotic events. Its structure contains a stereocenter: since …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… (ABCC4)-lower odds for daily dose reduction and clopidogrel-rs12353214 (PTGS1)-decreased drug stopping risk)).<br/><br/>In addition, out of 3 novel DDGIs, one association was validated using an alternative phenotype in UK Biobank. In the discovery cohort, carrying the G allele at rs9516519 (T>G) …
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Biochemische Charakterisierung des ADP-Rezeptors P2Y12 und pharmakologische Therapiekontrolle von Thrombozytenfunktionshemmern
… hemmt. Klinisch bedeutsame Substanzen wie Clopidogrel oder Ticlopidin imitieren diesen in vivo Effekt des NO, indem sie extrazellulär über eine Rezeptorhemmung Gi-Protein Stimulation verhindern. (Aktas et al., Biochem Pharmacol 2002; 64: 433-439) Dipyridamol und im Besonderen die …
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Σύγκριση τικαγκρελόρης με πρασουγρέλη σε οξέα στεφανιαία σύνδρομα : ο ρόλος τους μετά από αγγειοπλαστική και αντίσταση στην κλοπιδογρέλη
H αναστολή της συσσώρευσης των αιμοπεταλίων με την χορήγηση διπλής αντιαιμοπαταλιακής αγωγής είναι ουσιώδης φαρμακευτικός χειρισμός σε ασθενείς που υποβάλλονται σε εμφύτευση ενδοστεφανιαίας πρόθεσης. Όμως, περίπου το 30% των ασθενών που λαμβάνουν κλοπιδογρέλη παρουσιάζουν αυξημένη υπολειπόμενη στη …
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