Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"clonality"”.
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Klonalitätsanalyse mittels PCR-Amplifikation X-chromosomal-gebundener Gene (MAOA und HUMARA) am Beispiel von Leiomyomen des Uterus und deren Anwendung auf das Krankheitsbild des benignen metastasierenden Leiomyoms zur Klärung dessen Pathogenese
… In the first part a further method for the clonality analysis X-chromosomal-linked genes – besides the often used androgen-receptor-assay – was established on probes of uterine leiomyomata. The chosen gene locus was that of the MAOA gene, which has already been useful for this PCR-analysis …
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Investigating lesions of Langerhans cells and their role in Lymphoproliferative diseases
… all cases reported to date have been monoclonal. Clonality argues for LCH as a neoplastic rather than reactive disorder. After initial investigation of the limitations of formalin fixed paraffin embedded tissues for downstream analysis, lesions of LCH were collected from 4 sites across Scotland. …
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Drivers of reproductive variability in Vaccinium cespitosum and vaccinium vitis-idaea in northeastern Minnesota
… land management decisions. I investigated how clonality impacts reproductive variability in Vaccinium cespitosum and Vaccinium vitis-idaea (Ericaceae), and how the history of land management affects reproductive variability in V. cespitosum. Vaccinium populations with a history of land …
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Evaluation of TP53 and IGHV clinical molecular prognostic testing for patients with Chronic Lymphocytic Leukaemia at Tygerberg Hospital
… was assessed using a two-step approach, firstly clonality was determined via fragment analysis by capillary electrophoresis of framework regions of the heavy chain variable region (FR1, FR2, FR3 VH), followed by bi-directional Sanger sequencing of clonal samples from genomic DNA (gDNA). A total …
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THE ROLE OF MOLECULAR SIGNATURES IN COMPLICATED CELIAC DISEASE
… were stratified based on the combination of TCR clonality and aberrant phenotype, there was no significant difference in outcomes among those with one or both markers altered. The presence of aIELs>20% demonstrated good diagnostic performance for RCD2 (AUC 0.95, 95% CI 0.8791-1.000; p < 0.01); …
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Integrative Cancer Immunogenomic Analysis of Serial Melanoma Biopsies Reveals Correlates of Response and Resistance to Sequential Ctla-4 and Pd-1 Blockade Treatment
… sequencing), we demonstrated that a higher TCR clonality in pre-treatment biopsy was predictive of response to PD-1 but notCTLA-4blockade. We also observed increased TCR clonality after CTLA-4 blockade treatment in patients responding to the following PD-1 blockade treatment. Analysis of copy …
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DDRAD-seq based identification of genetic markers to facilitate the assessment of clonal versus sexual reproduction in dichrostachys cinerea
… individuals in order to ascertain whether clonality could be detected within the species, via the use of a genetic-distance-based threshold value which would discriminate between clonal and non-clonal individuals. Findings from this study revealed that across its species range, D. cinerea …
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Computational methods for the detection of somatic structural variants in cancer genomes using long-read sequencing
… SAVANA performs robustly across a variety of clonality levels, genomic regions, SV types, and sizes. Using Illumina and Oxford Nanopore whole-genome sequencing data from 99 tumours and matched normal samples of patients, I show that SVs reported by SAVANA are highly concordant with those …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… Mock-treated animals. In the V(D)J analysis, the clonality of cells in plasma cell clusters from ICB-treated mice was greater compared to equivalent cells from Mock-treated mice. However, the opposite was true for cells within germinal centre clusters. Finally, antibodies from the top expanded …
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Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing
… studies of MMRD tumours showed that the clonality rather than the burden of mutations determines the variable responses to ICB observed in the clinic. Given that the clonality of mutations is determined by the evolutionary dynamics and patterns of intra-tumour heterogeneity, it is …
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Illuminating Clonal Dynamics: Development and Use of a High-Throughput Cellular Barcoding System to Track Clonal Evolution
… the contributions of individual cells to the clonality of large homogenous populations, however, have been constrained by limitations in sensitivity and complexity. We have created an efficient and high throughput method to overcome these limitations by harnessing the power of viral marking …
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EPIDEMIOLOGY AND POPULATION GENETICS OF THE GRAPE POWDERY MILDEW CAUSAL FUNGUS, ERYSIPHE NECATOR, AND ITS RELATION TO COMMERCIAL DISEASE MANAGEMENT
… How accurately can disease severity predict the clonality or aclonality of single colonies? ii) Can a disease-date threshold be identified, by which if severity doesn’t exceed a given level by a certain late Summer date, pathogen winter survival can be prevented? iii) At what frequency are known …
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Patterns of evolution in a young species, the Baltic seaweed Fucus radicans
… event. We investigated the spatial patterns of clonality in F. radicans, to understand how clones affect the potential for sexual reproduction, recombination and local adaptation. Results showed that rare sexual events, occasional long-distance migration and somatic mutations of large clones …
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Diversity and virulence of the genus Cronobacter revealed by multilocus sequence typing (MLST) and comparative genomic analysis
… The MLST scheme also revealed the high level of clonality in the species C. sakazakii and C. malonaticus. ST4 was found to be a highly stable clone of C. sakazakii, and a strong association was established between the C. sakazakii ST4 clonal complex with neonatal meningitis cases.
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The genomic characterization of carbapenemase-producing Serratia marcescens at a tertiary hospital in South Africa
… Though distinct clusters were observed, no clonality was noted, and a limited number of isolates shared plasmids. This study provides genomic data for emerging CRSM and highlights the importance of ongoing genomic surveillance to inform infection prevention control and antimicrobial …
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A citywide, clonal outbreak of Pseudomonas aeruginosa during a drought
… sequence typing were used to determine clonality and identify virulence genes. A modified case-control study in a subset of patients with bloodstream infection compared demographic and clinical characteristics between sequence types. Results The outbreak lasted 10 months from December, …
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Tumour evolution and novel biomarkers in breast cancer
… as the most reliable tool to classify tumour clonality. The mammary gland is known to be highly sensitive to radiation, especially at a young age. In the years from 1920-1965, a total of 17,200 female Swedish infants were treated with ionizing radiation for skin haemangioma, resulting in an …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… activation of T effectors, and increased T-cell clonality and clonal diversity. We observed significantly higher complete response rates to RSP in both irradiated and abscopal tumors and prolonged survival in three distinct murine CRC models, including a cecal orthotopic model. In murine CRC, …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
… experimental strategy for investigating the clonality of transdifferentiation in the microenvironment of pancreatic cancer.
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Sex, Diversity, and Differentiation Within and Between Populations of an Aquatic Hyphomycete
… of T. marchalianum , providing evidence for clonality in this species. All Illinois sites, although spatially separated within rivers and between rivers in different watersheds, demonstrate no significant differentiation. Significant differentiation between populations was only observed …
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