Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"clonal tracing"”.
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Studying the Clonal Origins of Drug Resistance in Human Breast Cancers
… giving a new depth to our understanding of clonal selection in cancer. In particular, high complexity barcodes are used to identify a pre-existing tamoxifen resistant population in the MCF7 cell line. This resistance phenotype is then linked to the induction of embryonic transcription factor …
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Cellular Ensembles in Alveolar Homeostasis and Repair
… multi-apical domain architecture. Lineage tracing and live imaging coupled with genetic and AAV-mediated selective ablation of AT2s was used to show robust recovery of AT2 numbers and distribution via clonal proliferation and migration, even after three successive rounds of ablation. Clonal …
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Elucidating intratumour heterogeneity through investigation of clonal, transcriptomic, and proteomic features across models of triple negative breast cancer and diffuse intrinsic pontine glioma
… The previously developed WILD-seq lineage tracing technology is applied to the D2A1-m2 model of breast cancer metastasis, enabling the tracing of barcoded clones through RNA sequencing. With this, the utility of this technology is demonstrated by identifying clonal populations derived from …