Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"clonal relationship"”.
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… association studies that identified the relationship between MHC class II genes and ANCA specificity strongly support the role of CD4 T helper cells in the pathogenesis of AAV. Recently a new subset of T cells called peripheral T helper (PTH) cells, characterised by the PD1+CXCR5- …
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Intestinal challenges shape the polarisation of dural meninges memory CD4+ T cells
… populate the dura mater, but their phenotypic or clonal relationship to gut counterparts or role in local anti-pathogenic immune responses has been less studied. Using mouse models, we show that dural CD4<sup>+</sup> T cell effector states are highly responsive to intestinal perturbations. We show …
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Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis
… comparison of diagnostic and relapse clonal relationship showed evolution from an ancestral clone in the majority of cases, highlighting similarities in childhood and adult disease. In addition, the analysis revealed several recurrent cryptic genetic events not previously implicated …
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Staphylococcus aureus en animales de vida libre y medioambiente. Resistencia a antimicrobianos, virulencia, líneas genéticas circulantes y genómica comparativa
… In 2005, for the first time, a genetic MRSA clonal complex CC398 was detected associated with livestock (MRSA-LA), whose main reservoir are pigs. Since then, it has been observed a large dissemination of this genetic lineage, as well as the transmission to people in direct or indirect contact …
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Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia
The aim of this thesis was to analyze the genetic and epigenetic characteristics of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH ALL), the most common type of childhood malignancy. The three original articles presented in this thesis have addressed three major questions regarding …