Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"clonal deletion"”.
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Staphylococcal Enterotoxin B Induced Clonal Anergy in αβ T Cell Receptor Transgenic Mice
… used to study T cell tolerance. While both clonal deletion and apparent anergy have been described in response to superantigens, it has not been clear whether true anergy occurs, or whether the most reactive T cells are selectively deleted, leaving less reactive clones. To address this …
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Overcoming T Cell Tolerance Against Endogenous Choroid Plexus Tumors Using a Combination Immunotherapy
We target T cells escaping clonal deletion to study effects of a combination of immunotherapies against endogenously arising choroid plexus tumors. The model we use is the SV11 mouse transgenic for large T antigen of simian virus 40. Mice are immunologically tolerant to the choroid plexus tumor. We …
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… revealed a potential role for Foxo3 in promoting clonal deletion. Foxo3-/- mice also have reduced frequencies of pre-B and mature recirculating B cells in the blood and bone marrow. The mice demonstrate increased basal levels of IgG2a, IgG3, and IgA. Thus, Foxo3 deficiency affects numerous aspects …
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Aspects of T cell development contributing to autoimmunity.
… derived cells. This process might contribute to clonal deletion of insulin-reactive T cells. The NOD mouse displays thymocytes apoptosis resistance, which could also contribute to impaired negative selection and contribute to the development of type 1 diabetes. By analysing the expression of key …
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On Thymic Regulatory T-Cell Ontogeny
… lineage specificity, and negative selection or clonal deletion to eliminate autoreactive T cells. The induction of the Treg population is triggered when autoreactive cells escape from negative selection. Despite significant progress in our understanding of thymic T-cell differentiation, …
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B cell signalling in mechanisms of central and peripheral tolerance
… peripheral developmental checkpoints ensure the deletion of self-reactive B cells and selection of tolerant B cells. For example, antigen-driven ligation of the B cell receptor (BCR) on immature B cells results, by default, in receptor editing, anergy and/or apoptosis, whereas it provides …