Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"clofibrate"”.
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Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia
… profile of synthetic PPARα agonists as clofibrate by motor activity test to evaluate possible motor impairments, the forced swim test (FST) for the antidepressant activity, the elevated plus maze (EPM) and the social interaction test (SI) for anxiolytic like effects. The standard …
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Effect of cell- and species-differences in the expression of drug metabolism enzymes on chemical-induced injury to the rat and human kidney
… kidney microsomes but not in rPT and rDT cells. Clofibrate induced CYP4A and CYP2B only in liver and kidney microsomes and also CYP2E1 and CYP2C11 in kidney microsomes. The GST isoforms responsible for GSH conjugation of Tri were also determined. Pyridine treatment increased CH formation in rat …
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Preparation and solid state properties of cyclodextrin complexes of selected drug molecules
… β-cyclodextrin (Trimeb) complex with clofibrate is reported. The complexes were characterised by thermogravimetric analysis (TG), differential scanning calorimetry (DSC), ultraviolet spectrophotometry (UV), infrared spectroscopy (IR), X-ray powder diffraction (XRD) and single crystal …
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Dry Period Nutrition and Hepatic Metabolism of Fatty Acids and Glucose in Transition Dairy Cows
… calves were treated with both synthetic (clofibrate) and naturally occurring (fish oil) PPAR-alpha agonists to determine if male Holstein calves are a suitable model for studying liver fatty acid metabolism in adult Holstein cows and to determine if PPAR-alpha agonists alter ruminant liver …
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Design and Application of Probes of Novel Bioactivities
… presence of external signals, such as the drug clofibrate and biotic stress, were studied. Confocal microscopy enabled the dynamics of the peroxisome to be visualised in a variety of cell types and species, including both plant and mammalian cells. In addition to this computational studies were …