Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"clock genes"”.
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DNA Sequence and Haplotype Variation Analyses of Circadian Clock Genes and Their Effects on Phenotypes in the Turkey, Meleagris gallopavo
… its associations with performance traits. The turClock, turPer3, turCry1 and turCry2 genes were screened and evaluated for its association with their performance traits. As expected, CC turkeys were superior to heritage birds in performance for most of the traits evaluated. However, heritage …
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Alternative splicing in the regulation of the barley circadian clock
… expression. The novel work on AS in Arabidopsis clock genes coincided with availability of the barley genome sequence and the rest of my PhD was spent in examining AS in the circadian clock of barley.<br/> Prior to this thesis, extensive alternative splicing (AS) was shown to regulate clock genes …
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FROM CLOCKS TO EXERCISE, FROM METABOLISM TO PERFORMANCE: A CHRONOPHYSIOLOGICAL APPROACH
… of temperature regulation, metabolism, and clock genes in determining exercise physiology. The complex interaction between the central biological clock and peripheral clocks is described, with a focus on clock genes such as Cry1 and Cry2, which are crucial in regulating metabolic processes …
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Investigating the role of the circadian clock in the physiology of wheat
The circadian clock is an endogenous timing mechanism which acts to synchronise internal processes with daily and seasonal cycles in light and temperature. In Arabidopsis, the components which comprise the circadian oscillator and output pathways are well defined. Photoperiod dependent flowering, …
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Molecular and biochemical characterisation of phosphorylation-dependent NICD1 turnover: novel roles for CDK1 and CDK2
… mesoderm (PSM). The rhythmicity of somitogenesis is regulated by a molecular clock called the segmentation clock that drives the periodic expression of a number of “clock” genes in the PSM, with a periodicity that matches somite formation. Clock genes belong to the Notch, Wnt and FGF …
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Investigation of the SCN 2.2 Cell Line as a Model of the Central Mammalian Circadian Pacemaker
… revealed that this cell line expresses putative clock genes, as well as components of daytime, nighttime and crepuscular circadian regulatory pathways. The line also expresses several antigens that are highly expressed and/or relatively restricted within the hypothalamus to the SCN. Stable SCN …
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Chronobiological plasticity in Honeybee and its association with differences in the organization of the molecular pathway between central and peripheral clocks: the brain and flight muscle tissues.
… tasks in the nest, nursing brood around the clock, with no circadian rhythms for the 2 3 first weeks, and then shift to foraging outside for the remainder period of life, enabling visiting flowers at time of maximal nectar and pollen availability. In addition to light, social cues is one of …
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Role of Aryl Hydrocarbon Receptor in Circadian Rhythm: A Novel Pathway to Dioxin Toxicity
… AhR as a basic component of the molecular clockwork, the circadian mRNA expression of AhR and its signaling targets in the suprachiasmatic nucleus (SCN), the master clock, and in the liver, a peripheral clock, were determined in mice. The circadian phenotype was also characterized in mice …
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Uncovering Molecular Mechanisms Regulating Circadian Amplitude Across the Tree of Life
… feedback loops formed by genes termed core clock genes. Some of these clock genes function as transcription factors to control the timely expression of each other as well as thousands of downstream clock-controlled genes. The amplitude of circadian rhythms, or the daily …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY SYNTHETIC AHR AGONIST BETA-NAPHTHOFLAVONE IN MICE
The circadian clock system is essential for mammals to adapt to environmental conditions such as light-dark cycles and to manage the optimal timing for cyclical physiological processes, including sleep-wakefulness, fasting-feeding and multiple aspects of metabolism. The circadian timing system is …
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The role of serotonin-2C receptors in the rat circadian system.
… of 5-HT2C receptor agonist administration on clock gene expression were investigated in the rat SCN. Systemic administration of the 5-HT2A/2C agonist DOI to rats during early night induced c-fos, Per1 and Per2 expression in a manner similar to light. This response was time of day dependent …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… basis of the circadian timekeeping involves clock genes which act as transcription factors in a serious of feedback loops. Disruption of clock genes in transgenic models leads to dysregulation of the temporal architecture of behaviour and physiology. The master circadian pacemaker is the …
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The interdependent regulation of photosynthesis and the circadian clock in wheat
The circadian clock is an endogenous timing mechanism that allows organisms to coordinate physical and behavioural processes with the natural light dark cycle. Synchronisation between the circadian clock and environment in plants provides a fitness advantage (Dodd et al. 2005) and in wheat several …
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EVALUATING THE CHEMOTHERAPEUTIC EFFECTS OF SR9009 AND ESOMEPRAZOLE ON ORAL SQUAMOUS CELL CARCINOMA USING CIRCADIAN-TAILORED INNOVATIVE THERAPEUTIC APPROACHES
… New potential triggers, including circadian clock disruption that is caused by multiple lifestyle traits such as chronic gastroesophageal reflux and human papillomavirus (HPV) infection are emerging new causal factors that might be responsible for higher population incidence of OSCC among …
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UNDERSTANDING HEPATIC REV-ERBa INTERACTING PARTNERS AS IT PEAKS AND TROUGHS THROUGH THE CIRCADIAN DAY
… they play important roles in the circadian clock and in the regulation of metabolism on a variety of tissues. Understanding how a factor can link both the clock and metabolism could be the key to understanding the negative effects that circadian misalginment has on metabolic and overall …
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The effects of the noradrenaline reuptake inhibitor atomoxetine on circadian rhythms in mice.
… conditions (to look at the endogenous circadian clock without influence of environmental factors like light). Results have shown that atomoxetine produces a novel resetting of circadian time in mice, producing significant phase delays in animals in constant light and phase advances in animals in …
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Signatures of natural selection and local adaptation in Populus trichocarpa and Populus deltoides along latitudinal clines
… studies have revealed the role of the circadian clock in synchronizing the timing of dormancy and physiology for conferring fitness in trees. To better understand the possible role of natural selection on circadian clock-related genes in climatic adaptation, I took a candidate gene approach, …
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