Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"clinical treatments"”.
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Influence of Fibroblasts on Metastatic Cancer Cell Drug Resistance in a 3D Microfluidic Cell Array
… In cancer therapy specifically, the outcomes of clinical treatments are heavily dependent on drug testing methods despite the cytotoxic effects these methods might have on the patient. Our lab has previously developed a three layered microfluidic cell array (3D μFCA) to reconstruct the relevantly …
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At Risk for PTSD: The Public Health Implications of Trauma
… shifted focus from traditional public health to clinical treatments for PTSD (tertiary prevention) and then to an overview of the factors associated with risk for PTSD (primary and secondary prevention). In this paper, I present those findings as well as my perspective on trauma as a public …
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Multifunctional bioactive polymers for the fabrication of tissue engineering scaffolds and the treatment of tissue ischemia
… study should be readily translated into various clinical treatments for neovascularization. Ultimately, the results of this thesis study will greatly contribute to expediting the use of tissue engineering technology of various injuries, traumas, and diseases.
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Common and Distinct Neural Mechanisms of Fear Acquisition and Reversal in comorbid Autism with Social Anxiety and Social Anxiety Disorder uncomplicated by Autism
… than these individuals are diagnosed with other clinical disorders, including depression and other anxiety disorders. However, there is little research on whether the presentation and neural underpinning of comorbid SAD within the context of ASD is the same as SAD alone. Individual and diagnostic …
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Reducing Maternal Morbidity from Peripartum Hemorrhage in Cesarean Delivery
… factors (maternal age, race, and ethnicity), clinical and physiologic factors, which include coexisting medical conditions (preoperative laboratory values, American Society of Anesthesiologists [ASA] physical status classification, obesity, anemia, smoking, hypertension, diabetes, chronic …
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In vivo lumbar spine biomechanics : vertebral kinematics, intervertebral disc deformation, and disc loads
… and pathology, for improvement of corresponding clinical treatments, and for design of spinal prosthesis. However, due to the complicated spine anatomy and loading conditions as well as high risks in these direct measurements, it has been a challenge to determine the in vivo biomechanics of the …
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Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
… understanding PCa development and developing clinical treatments in the past decades, the exact mechanisms of PCa are still not clearly understood. Emerging evidence has postulated that a population of stem cell-like cells inside a tumor, termed ‘cancer stem cells (CSCs)’, may be the cells …
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Cerebral haemodynamics in man: Clinical and applied observations
… perfusion imaging techniques, initially in the clinical setting (in clinic, at the bedside and in the operating theatre) and later transferring these methods to the field setting at high altitude. As a result of these studies, new insights into cerebral perfusion have been gained. Novel concepts …
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Development and Characterization of Tunable, Bioinspired Electrospun Constructs for Skeletal Muscle Engineering
… the injured muscle and surrounding tissues. With clinical treatments failing to repair lost tissue, there is a great need for tissue-engineered therapy to promote skeletal muscle regeneration. This thesis focused on the development of a bio-rich material with tunable physicochemical properties to …
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Molecular and Functional Analysis of Otolith Formation in Zebrafish, Danio Rerio
… or death in the elderly. Unfortunately, the clinical treatments for BPPV are limited, and BPPV often recurs in treated patients. In order to understand the molecular mechanisms of otolith and otoconia biomineralization, we performed a biochemical analysis of fish otoliths. Although there are …
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Poly(ethylene glycol)-based open-channel blockers for the acetylcholine receptor : mechanistic and structure-function studies at the single-channel level
… impede current flow. They have been used in both clinical treatments of diseases and fundamental researches of synaptic transmission. However, the rational design of open-channel blockers is challenging, mainly due to the paucity of high-resolution structures for the pore regions of ion channels. …
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Identification, Molecular Cloning and Functional Characterisation of Novel Bioactive Peptide Drugs from Amphibian Skin Secretions
… drug discovery and provide new prospect for clinical treatments.
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Computer Simulations for Applications of Magnetic Resonance Guided Focused Ultrasound Surgery (MRgFUS) of Uterine Fibroids
… to perform thermal ablation, has been used clinically as an alternative to hysterectomy to treat UFs since receiving clinical approval in North America and Europe nearly two decades ago. Despite the advantages of MRgFUS being uterine sparing and having a shorter recovery time compared to …
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Magnetic Steering to Save Sight: Trabecular Meshwork Cell Therapy as a Treatment for Primary Open Angle Glaucoma
… POAG is high intraocular pressure (IOP). Current clinical treatments for POAG aim to reduce IOP, but they often have low success rates. The trabecular meshwork (TM) is a key regulator of IOP and has been shown to undergo significant changes in POAG including a loss of cells. This motivates the …
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The utility of bioimpedance cardiography in assessing the influence of obstructive sleep apnea hypopnea syndrome on cardiac function
… state, but also possible beneficial effects of clinical treatments. Objectives (Study 1): The aim of this study was to determine the reproducibility of select cardiac variables when monitoring a simulated sleep apnea event using a new improved bioimpedance cardiography system. Methods: Fifteen …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
… endogenous ability for self-repair and current clinical treatments for damaged or diseased cartilage tissue are insufficient. Additionally, there is a biological and mechanical interplay between cartilage and the underlying subchondral bone, linking the pathogenesis/regeneration of both tissues. …
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A control theoretic approach to mitigate viral escape in HIV
… switched dynamic system. Consequently we test clinical treatments and allow preliminary control analysis for switching treatments. After introducing the biological background and models, we formulate the problem of treatment scheduling to mitigate viral escape in HIV. The goal of this therapy …
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DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… VTA GABA signaling and to unveil effective clinical treatments to reverse dysregulated inhibitory signaling in individuals suffering from substance use disorders.
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Advanced in situ hydrogel assembly for guiding molecular release
… products, food additives, sensor devices, and clinical treatments.
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Reti complesse e analisi del segnale elettroencefalografico
… been also emphasized in monitoring the effect of clinical treatments and in evaluating the progression of brain disorders. Graph theory and network science tools have revealed fundamental mechanisms of functional brain organization in resting-state M/EEG analysis. Nevertheless, it is still not …
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