Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"clinical risk"”.
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Clustering-Based Methods for Clinical Risk Prediction of Rare Missense Variants
A long-standing goal in clinical genomics is to map individual genetic variants to clinical outcomes. Typically, variants which lead to loss of function (e.g. nonsense or stop-codon inducing variants, frameshifts, or deletions) are more easily classified as pathogenic in an established disease …
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Improving Clinical Risk Models through Integration of Polygenic Risk Scores and Omics
… to disease research. Methods such as polygenic risk score analysis have been presented to enhance disease risk prediction, however, the clinical utility of these methods are controversial. Similarly, the identification of genes associated with likely causal SNPs is unclear as identified SNPs …
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Improving clinical risk-stratification tools : instance-transfer for selecting relevant training data
One of the primary problems in constructing risk-stratification models for medical applications is that the data are often noisy, incomplete, and suffer from high class-imbalance. This problem becomes more severe when the total amount of data relevant to the task of interest is small. We address …
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Liability for Negligent Healthcare Clinical Risk Management in the United States and Germany
… in systems-based learning through the process of clinical risk management (CRM). Although both jurisdictions do recognize organization-based theories of liability, liability for negligent CRM has not been explicitly recognized by courts in either jurisdiction to date. German legal scholars, …
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Application and Extension of Weighted Quantile Sum Regression for the Development of a Clinical Risk Prediction Tool
In clinical settings, the diagnosis of medical conditions is often aided by measurement of various serum biomarkers through the use of laboratory tests. These biomarkers provide information about different aspects of a patient’s health and the overall function of different organs. In this …
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Challenging frontal lobe capacity using lateralized vestibular stress: A functional cerebral systems approach to a clinical risk for falls
A conceptual model was originally proposed that linked the vestibular modality with executive domains by means of a functional cerebral systems framework. The claim was that frontal regions exert regulatory control over posterior systems for sensation and autonomic functions in a dense, …
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Risk and prediction of violent crime in forensic psychiatry
… and various combinations of criminological and clinical risk factors among violent offenders in a prospective Swedish follow-up study. Subjects: One hundred violent offenders, consecutively admitted for forensic psychiatric investigations between 1998 and 2001 (baseline). Methods: Psychiatric …
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Relation between carotid artery FDG uptake and cardiovascular risk in asymptomatic adults
… carotid artery FDG uptake and cardiovascular risk based on the Framingham risk score (FRS), and evaluated the possible role of FDG uptake in terms of risk stratification of asymptomatic adults. We evaluated 290 adults who underwent FDG PET/CT as part of general health screens. We calculated …
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The assessment and treatment of violence in personality disordered offenders
… issues to be considered when appraising risk within clinical practice. Chapter 1 reviews the relevant literature and outlines the remaining thesis. A systematic review evaluating Dialectical Behaviour Therapy (DBT) with borderline personality disordered (BPD) inpatients can be found in …
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Suicide-Related Imagining and Acquired Capability: Investigating the Role of Imagery in Self-Harm Behaviors
… mental imagery could play an important role in clinical risk assessment and treatment for suicidality, and that further research is needed to clarify the mechanisms underlying the relationship between suicide-related mental imagery and suicidal behavior.</p>
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A Modern Statistical Approach to Quality Improvement in Health Care using Quantile Regression
… across providers. Accounting for the latter with clinical risk adjustment models is a complicated and controversial topic, as providers are increasingly paid based on their performance with respect to risk-adjusted quality measures. A modern approach to hospital quality improvement is developed by …
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Proteomic Signatures of Type 2 Diabetes and Related Metabolic Traits
… strategies to identify individuals at high-risk. However, the aetiology of this heterogenous disease remains incompletely understood, and some subgroups are poorly predicted or overlooked. The main aim of this thesis was to identify plasma proteomic signatures for improved risk prediction …
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Predicting the risk for postoperative delirium using routine EEG monitoring data
… vulnerability patterns predictive of POD beyond clinical risk factors. We analyzed two cohorts of elderly patients from Charité Berlin: SuDoCo (n=1032, ≥60 years) and ePOD (n=263, ≥70 years), recorded 10 years apart with different anesthetic protocols. We developed a novel two-step burst …
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Deep learning survival analysis for clinical decision support in deceased donor kidney transplantation
… in order to maximize patient survival. Risks affecting patient survival post-KT must be balanced with the risks of remaining on the waitlist. These risks include mortality, graft failure, and becoming too sick to transplant. The allocation system today takes these risk into account by …
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Molecular Classification of Bladder Cancer
… treatment of bladder cancer today are based on clinical and pathological risk variables such as tumor stage and tumor grade. The importance of these conventional risk variables is well documented since more than 10 years, and they are used routinely in the clinics. Over the last ten years, …
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The influence of poverty on the development and maintenance of conduct disorder and perpetuation of crime and violence
… associated with poverty, and the Historical/Clinical/Risk Management (HCR-20). My results indicate that my measure of respondents’ income was not associated with propensity for crime. However, severity of CD and an increased number of S-E factors of poverty were positively associated with …
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Ottimizzazione della logistica in ambito sanitario attraverso l'uso di sistemi RFID
… flow charts, activity forms, Idef0 language. A Clinical Risk analysis was carried out, in order to highlight criticalities related to efficiency and effectiveness (patient safety), and to quantitatively classify them. Particularly FMECA and CREA methods were adopted. The analysis was followed by …
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Adverse Effects of Asparaginase in Pediatric Patients with Acute Lymphoblastic Leukemia
… treated on an asparaginaseintensive front-line clinical trial. Of 169 patients (41.2%) who exhibited clinical allergy, 147 (87.0%) were positive for anti-Elspar antibody. Of 241 patients without clinical allergy, 89 (36.9%) had detectable antibody. Among those positive for antibody, the antibody …
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Evaluating the impact of embedding the Collaborative Assessment and Management of Suicidality (CAMS) intervention into the NHS, including service user and clinician outcomes for its utility
… the methodological evaluation of a bespoke clinical risk service improvement initiative within a National Health Service (NHS) mental health organisation. The specific operational components of this initiative were informed by preceding review chapters of pertinent literature for …
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Prevalence of acute deep vein thrombosis in HIV seropositive orthopaedic patients after major surgery at the University teaching hospital, Lusaka.
… states and immobilization are known risk factors in the development of DVT after major orthopaedic surgery. However, the added effect of HIV to major orthopaedic surgery in developing DVT is unknown. In addition the benefits of D-dimer screening of patients after major surgery is not …
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