Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"clinical response"”.
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Course of clinical response during primary systemic therapy with a dose-dense 4 cycles regime of adriamycin and docetaxel in patients with operable cancer of the breast
… systemic therapy (PST) allows the observation of clinical response under treatment, serving as an in-vivo chemosensitivity test. One possibility to assess tumor response is the consideration and analysis of clinical parameters such as palpation of the tumor size. <br>Up to now, little is known …
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Serotonin receptor mechanisms in anti-depressant action
… in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter. Additionally, serotonin pathways may playa role in the pathophysiology and treatment of eating disorders, anxiety states and schizophrenia. Molecular biological studies have …
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DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort
… gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and P2RY12 gene expression.
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Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
… (TIL) from metastatic melanoma patients. Clinical trials of adoptive T-cell therapy (ACT) using autologous <em>ex vivo </em>expanded TIL have demonstrated the great potential of this immunotherapy with an overall clinical response rate 40-50% for stage IV metastatic melanoma patients. We …
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Predicting adherence to antiretroviral therapy and retention to HIV care : effects of baseline biopsychosocial status and neuropsychological functioning
… adherence is a prerequisite for optimal clinical response and prevention of drug resistance.
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Pharmacogenetic markers of response to drugs used in the management of Inflammatory Bowel Disease
… is effective but limited by side effects and non-response. We aimed to identify pharmacogenetic markers of response to commonly used immunosuppressive medication in these patients.<br/>Methods: The influence of MTHFR 677C>T, MTHFR 1298A>T, ATIC 347C>G, TSER *2/*3 tandem repeat, TYMS 3’-UTR 6 bp …
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Heterogeneity in hyperkinetic disorder
… the associated neuropsychological deficits, the clinical presentation and response to treatment. This work investigated whether the more restrictive and clinically homogeneous hyperkinetic disorder (HKD) phenotype is associated with reduced neuropsychological heterogeneity compared with the …
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Longitudinal changes in clinical symptoms and signs in children with confirmed, unconfirmed, and unlikely pulmonary tuberculosis
… microbiology for assessing treatment efficacy. Clinical response to treatment has thus been used by clinicians to monitor disease activity, as well as by researchers in clinical case definitions of intrathoracic TB to differentiate those with unconfirmed PTB from those with other lower …
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Characterization and Optimization of Antigen-Specific T Cell Responses During Ex Vivo Expansion of Melanoma Tumor-Infiltrating Lymphocytes
… is a promising approach associated with a high clinical response rate. However, further optimization of this treatment modality is required to increase the clinical response after this therapy. ACT in melanoma involves an initial phase (pre-REP) of tumor-infiltrating lymphocyte (TIL) expansion …
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The development and evaluation of a hydrogel drug delivery system for dithranol.
… evaluated on 5 normal and 8 psoriatic patients. Clinical response was measured by scoring scaliness, thickness, erythema and staining. Detailed time course evaluation on two psoriatic patients indicated that there was a lag time of 7 hours after application before the first clinical response was …
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Elucidating the Target and Selectivity of a Non-Small Cell Lung Cancer Toxin
… reductive aspartate synthesis would enhance clinical response to Complex I inhibitors.
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Quantifying T cell Mediated Killing for Melanoma Immunotherapy
… refractory to all other treatment methods with clinical response rates of ~50%. Despite numerous improvements in the last decade, ACT treatments still result in a wide range of outcomes. Functional heterogeneity, at the single-cell level, of cells infused for ACT has not been routinely …
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Translational Neuroimaging of Emotion Processes in Posttraumatic Stress Disorder and Depression
… (MDD), which are linked to altered neural response patterns. However, inconsistent results have led to questions about the reliability of such findings. Heterogeneous clinical presentations across individuals with PTSD and MDD are likely to be associated with heterogeneous neurobehavioral …
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Implementation of an Innovative Early Warning System: Evidenced-based Strategies for Ensuring System-wide Nursing Adoption
… based on a complex algorithm of laboratory and clinical data points. Improvements in mortality and length of stay have been realized at the two pilot hospitals. In anticipation of expansion to additional NCAL facilities, major changes to the AAM workflows and processes were developed that …
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Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
Despite significant advances in cancer treatment, clinical response remains suboptimal and there is a continued requirement for improved chemotherapeutics. The attrition rate for new therapies is high, due principally to lack of in vivo efficacy and poor pharmacodynamics. Consequently better …
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Bayesian Designs For Early Phase Clinical Trials With Novel Target Agents
… mainly focus on Bayesian designs for early phase clinical trials with novel target agents. It includes three specific topics: (1) reviewing novel phase I clinical trial designs and comparing their operating characteristics; (2) Proposing a Bayesian optimal phase II clinical trial (BOP2) design …
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Advanced breast cancer: A retrospective review comparing two palliative radiotherapy protocols used at Groote Schuur Hospital between 2010 and 2013
… previous chemotherapy with minimal or no clinical response, as well as hormonal treatment. Results: Forty three patients were followed up over a median period of 24 months, 14 of which received 20Gy and 29 received 36Gy. The average age was 64 years old. Compliance was 88% in both groups. …
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Development of a HPLC method for the determination of methotrexate (MTX) and MTX-polyglutamates of red blood cells: A dissertation submitted in partial fulfilment of the requirements for the Degree of Bachelor of Science with Honours at Lincoln University
… patients with rheumatoid arthritis (RA). Patient response to, the drug and development of side effects are poorly understood. There is large a variation in clinical response between patients and this influences the dose requirement. Therefore, there is a need for therapeutic drug monitoring to …
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The role of type I interferon in chronic lymphocytic leukemia
… autocrine IFN. Leukemic cells from patients with clinically aggressive disease expressed higher IFN receptor levels and heightened responsiveness to IFN. Enhanced IFN sensitivity was associated with chemoresistance to CLL therapies including bruton’s tyrosine kinase inhibitors such as ibrutinib …
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