Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"clinical efficacy"”.
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Does an objective laboratory measurement of platelet quality correlate with clinical efficacy?
… suitability of individual concentrates for clinical use. Many of the studies in this field investigate the in vitro association between concentrate age and test results. Not all quality indicators are equally informative because a number of storage associated changes correct upon infusion. …
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Bio-artificial liver support system : an evaluation of models used in demonstrating or improving metabolic and clinical efficacy
… liver failure (ALF) is a rare but devastating clinical syndrome with multiple causes and a variable course. The mortality rate is high. Orthotopic liver transplantation is the only therapy of proven survival benefit but the limited supply of donor organs, the rapidity of progression and the …
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An Investigation Of Master's Level Counseling Students' Clinical Efficacy: The Relationship Between Graduate Record Examination Scores And Demonstration Of Clinical Skills In Practicum
… graduate program as well as acquire effective clinical skills. The primary method of measuring achievement potential for graduate students in Counselor Education programs represents Graduate Record Examination Scores (GRE); minimal scores on the examination are required for program admission. …
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CLINICAL EFFICACY OF XENOGENEIC COLLAGEN MATRIX AS A COMPARATIVE ALTERNATIVE TO FREE GINGIVAL GRAFT IN AUGMENTING KERATINIZED MUCOSA WIDTH AROUND DENTAL IMPLANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
… xenografts and allografts (Dragan et al., 2017). Clinical studies have demonstrated a xenogeneic collagen matrix (XCM) potential as a means of increasing the width of keratinized tissue around dental implants without the need for an autologous graft and second surgical site (Rokn et al., 2020), …
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The Strategic Value Driver Model: a Methodology for Examining Value Drivers for a New Pharmaceutical Product in Diabetes
… product attributes (i.e., safety, convenience, clinical efficacy and cost) after asking the patients to report the importance of these attributes. The preference for inhaled insulin was used as dependent variable for running multivariable logistic regression with summated-scale score variables …
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Inflammation, Phagocytosis and Effect of Flunixin Meglumine During Endotoxin-Induced Mastitis (Therapy, Prostaglandins)
… flunixin meglumine in lactating cattle; (3) the clinical efficacy of the flunixin meglumine and its effect on milk and plasma TXB(,2) and PGF(,2(alpha)); and (4) changes of whey immunoglobulins and ability of wheys to enhance neutrophil phagocytosis of Staphylococcus aureus.
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ELUCIDATING AMPHETAMINE ACTIONS AT THE DOPAMINE TERMINAL: POTENTIAL FOR COCAINE ADDICTION TREATMENT
… of improved pharmacotherapeutics with high clinical efficacy and limited addiction potential. The work contained in this dissertation is focused on elucidating amphetamine’s actions on dopamine neurotransmission that underlie its therapeutic actions as well as its abuse potential.
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Pharmacologic investigation of the anti-inflammatory activity of cryogenine and selected benzoquinolizine derivatives
… agents have not been delineated nor has their clinical efficacy baan established or refuted. The centrally active drugs, cryogenine and tetrabenazine (a benzoquinolizine derivative), previously have been shown in this laboratory to inhibit certain models of induced inflammation. The present …
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Methods to enable the detection of targeted AmphDI glycosyltransferase mutants that transfer GDP-C2’epimycosamine to amphoteronolide
… of pathogen resistance is further weakening the clinical efficacy of most of these medicines. Amphotericin B (AmB) remains the last line of defense in treating these infections. Remarkably, this potent and broad-spectrum fungicidal agent has evaded pathogen resistance despite clinical utilization …
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METHYLPHENIDATE TREATMENT AND REARING ENVIRONMENT: EFFECTS ON THE DOPAMINE SYSTEM AND VULNERABILITY TO SUBSTANCE ABUSE IN ANIMAL MODELS
… at doses that have been associated with clinical efficacy in children, on the dopamine system and vulnerability to substance abuse in animal models. Methylphenidate is the most commonly prescribed stimulant to treat Attention Deficit Hyperactivity Disorder. As a dopaminergic agent, it has …
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A Meta-Analysis of Hydroxyurea Use for β-thalassemia: Implications for Clinical Practice and Medical Education
… review and meta-analysis to evaluate the clinical efficacy and safety of HU in patients with severe β-thalassemia. HU appears to be effective, well tolerated and associated with mild and transient adverse events; however, large randomized clinical trials (RCTs) should be done to confirm …
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Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum
… resistance. New antimalarial drugs with proven clinical efficacy against current drug-resistance cases of malaria including Plasmodium falciparum infections is critical to combact the disease and cope with the problem of further development or resistance.
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Targeting Stromal-Mediated Resistance Mechanisms in Oncogenic KRAS-Driven Pancreatic Ductal Adenocarcinoma
… emergence of resistance mechanisms limits their clinical efficacy. This dissertation investigates three interconnected aspects of PDAC biology and therapeutic targeting in the context of oncogenic KRAS. First, the thesis demonstrates that stromal-derived Neuregulin 1 (NRG1) activates upregulated …
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Real-time Quality Feedback System for Screening Colonoscopy
… evaluation system and the assessment of its clinical efficacy. The proposed tool consists of an embedded system that can automatically measure: a) the quantity of stool and waste matter existing within the patient during a colonoscopy procedure; b) withdrawal velocity; c) image clarity; and …
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The effect of degradation on the efficacy and utility of the biopharmaceutical enzyme Erwinia Chrysanthemi L-Asparaginase
… assess their true impact on product quality and clinical efficacy. The assumption that biopharmaceutical producers adopt is that partially degraded or aggregated protein variants are necessarily undesirable, which may not always be the case. This problem is relevant to the enzyme L-asparaginase …
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NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS
… of aggressive solid malignancies in the clinical setting. Unfortunately, due to multifactorial drug resistance and systemic toxicity the clinical efficacy of these drugs is severely limited. Platinum-acridine hybrid agents have proven to overcome multifactorial drug resistance in some of …
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Addressing Mental Health Issues and the Effectiveness of Cognitive Behavioral Therapy and Mindfulness-Based Interventions among Athletes
… injured athletes. These findings highlight the clinical efficacy of evidence-based psychological interventions for addressing mental health concerns in athletes and underscore the importance of integrating mental health services within sport environments to support both psychological health and …
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The Effect of Phosphodiesterase Inhibitors on the Induction of Gene Expression by Long-Acting beta2-Adrenoceptor Agonists and Glucocorticoids
… strategies have been proposed to enhance the clinical efficacy of PDE4 inhibitors. One of these is the use of dual PDE3/4 inhibitors, which in addition to providing superior anti-inflammatory activity when compared to a PDE4 inhibitor alone, will also promote bronchodilatation. The present …
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Omega-3 fatty acids and depression: epidemiological and experimental evidence
… depressive disorder demonstrated significant clinical benefit of omega-3 PUFA treatment compared to placebo (standardized mean difference in clinical measure of depression severity was 0.56 [95% CI: 0.20, 0.92] and 0.22 [95% CI: 0.01, 0.43], respectively; pooled analysis resulted in 0.38 [95% …
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Study of Potential Drug Interactions of Epidermal Growth Factor Receptor Inhibitors (EGFR inhibitors) in the Treatment of Non-Small-Cell Lung Cancer // Проучване на потенциални лекарствени взаимодействия при използване на инхибитори на рецептора на епидермалния растежен фактор (EGFR-инхибитори) при лечение на недребноклетъчен белодробен карцином
… of potential drug-drug interactions in clinical practice is important. The introduction of targeted therapy has led to new challenges. These drugs have been recently introduced into clinical practice and are not well-known to specialists in terms of their mechanism of action, …
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