Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"climbing fiber"”.
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Surface recordings of evoked field potentials from the cerebellum with a flexmea microelectrode array
… pathways to the cerebellar cortex, the mossy fiber and the climbing fiber pathways. The mossy fiber pathway forms a disynaptic input to Purkinje cells through the granular cells. This disynaptic input produces a multicomponent field potential composed of the P1, N 1, N2, N3, N4, and P3 waves. …
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The role of gene expression and aging in SCA1
… genes, Col18a1 and Cck, involved in PC - climbing fiber dynamics, I found splicing correlates with ataxia in the ATXN1[82Q] and ATXN1[30Q]-D776 mice. In order to validate RNA-seq targets and focus on the more biologically relevant splicing candidates, I developed and analyzed RNA-seq from …
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The Role of Microglia and Astrocyte in Spinocerebellar Ataxia Type 1
… Ikkβflx/tlx mice had a prominent deficiency in climbing fiber removal onto Purkinje cells. Due to the low impact of microglia on SCA1 pathology, I then focus on astrocytes and in particular, astrocytic Kir4.1/Kcnj10. Astrocytic Kcnj10 was downregulated throughout the brain of the knock-in …
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Molecular Mechanisms of Presynaptic Plasticity and Function in the Mammalian Brain
… that Syt7 is not localized to cerebellar climbing fibers (CFs). Wild-type (WT) and Syt7 knockout (KO) recordings at CF to Purkinje cell (CF-PC) synapses established that at near-physiological external calcium (Ca$_{ext}$) levels both genotypes displayed similar recovery from paired-pulse …