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Showing 1 to 20 of 36 for “"click reaction."”.
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Investigations into the Manipulation of 1,2,3-Triazoles and Towards an Asymmetric ‘Click’ Reaction of Meso Bis-Alkynes
… by their attempted application in an asymmetric ‘click’ reaction. The first chapter gives an outline to the importance of desymmetrization within organic synthesis, providing examples of the types of stereoselective reactions found within the literature. Attention is then focused on the field of …
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A Pretargeted Spect Imaging Strategy Employing Technetium-99M Based on Bioorthogonal Diels-Alder Click Chemistry
… that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory pathways of the <sup>99m</sup>Tc-peptide complexes for maximum tumor targeting with the <em>in vivo </em>“click” and minimum non-target …
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Development of a click chemistry approach for cancer cell targeting and evaluating the effect of protein corona on active targeting yield
… approach to target NPs to the cancer cells via click chemistry. Cancer cells are first metabolically labeled with an azide-modified monosaccharide (azidosugar). In the second step, NPs that are functionalized with highly-reactive cycloalkynes selectively bind to the cancer cells due to a …
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SYNTHESIS AND CHARACTERISATION OF NOVEL BIOPOLYMERS VIA CLICK CHEMISTRY
… azide–alkyne cycloaddition, as an efficient Click reaction, for the synthesis of novel biopolymers with a broad range of potential medical/industrial applications. The strategy is to develop a powerful tool for the synthesis of libraries of materials, which will be discussed in separate …
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STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
… the copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has contributed to drug discovery due to the high degree of dependability, efficiency, specificity and biocompatibility of the reactions and products. Using this well-known click chemistry reaction, a …
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Synthesis and solution state self-assembly of linear-dendritic block copolymers
… a particular interest in use of the so-called "click" reaction to be used as a facile means toward block copolymer synthesis.
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Leveraging Bioorthogonal Chemistry for Hyperpolarized Magnetic Resonance and Metal Uncaging
… hypothesize the potential use of bioorthogonal “click” reaction toward the development of a novel metal uncaging strategy. These innovative demonstrations of bioorthogonal chemistry highlight their potential in diverse areas of study.</p>
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Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids
The utilization of click chemistry to perform inter- and intramolecular ligation on DNA has become ubiquitous in the literature. Advances in copper (I) stabilizing ligands that prevent DNA degradation via redox pathways have provided nucleic acid researchers access to the efficiency and …
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Invention and implementation of technologies for continuous flow synthesis
… and then combines them in a regioselective click reaction utilizing copper tubing as the catalyst. Next, I have optimized a synthesis of nicardipine which is prescribed to treat high blood pressure. The nature of the project required that the final product be relatively pure (>90 %) so that …
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Relating structure and function: Discovery of novel inhibitors of myotonic dystrophy
… to select their own inhibitors using an in situ click reaction on the target. Hit molecules form the selection assay are multivalent and multitarget inhibitors. In addition, these multivalent ligands bind tighter than their monomeric counterparts and make specific base-binding contacts with their …
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A. Discovery of novel reactivity under the Sonogashira reaction conditions B. Synthesis of functionalized BODIPYs and BODIPY-sugar conjugates
… to synthesize substituted enediynes, coupling reactions between terminal alkynes and 1,2-cis-dihaloalkenes under the Sonogashira reaction conditions failed to give the corresponding substituted enediynes. Under these conditions, terminal alkynes underwent self-trimerization or tetramerization. …
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Synthesis and Evaluation of Trans-bilayer Cross Linking Phospholipids Based on Click (Azide-Alkyne) Chemistry
… with each other from the alkyl chain through click reaction to form bola-PC. Successful coupling of monomeric phosphatidylcholine derivatives would lead to synthesis of corresponding phosphatidylinositol molecules as future work. PC derivatives that were synthesized in this work were …
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Polymerní terapeutika pro imunoonkoterapii
… 5-azidopentanoic acid was used. An uncatalysed click reaction...
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Investigating the size effect of nanoparticles in Click Chemistry mediated cancer targeting
… our investigation of the size effect of NPs in Click Chemistry mediated cancer targeting. Realized by anchoring NPs onto the cell surface via metabolic glycoengineering for the cell surface placement of azido group followed by Click Chemistry mediated covalent reaction between the NP and the …
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Kinetics of Polymer Interfacial Reactions
The reaction of a functional polymer at an interface has very broad applications in industry. Surface-bound polymers have been employed to control surface properties ranging from wettability and adhesion to friction and biocompatibility. More recently, the applications of functional polymer films …
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Poly(p-xylylene) Nanotubes Prepared via the Tubes by Fiber Templates Process as Catalytic Nanoreactors
… template material, the tubes were suitable for “click” chemistry (more precisely, the azide-alkyne Huisgen 1,3-dipolar cycloaddition), and were subsequently equipped with either a (2,2,6,6-tetramethylpiperidin-1-yl)oxy (TEMPO) catalyst or a bipyridine ligand. The bidentate chelating ligand was …
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Investigation of Copper Wire-Mediated Controlled/Living Radical Polymerization
… It requires low catalyst loading and mild reaction conditions, but does involve use of organic solvents. There is a need for greener solvent systems to replace traditional volatile organic solvents without detrimentally affecting polymerization. The effects of greener solvents on control …
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Design and Synthesis of a Macrocyclic Phospholipid
… derived from the precursor to the second click reaction, and a linear amphiphile created from a glutarate bis-dodecyl ester, were also synthesized to provide controls for probing the orientation of the macrocyclic phospholipid in the bilayer membrane of vesicles. The amphiphile, linear …
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… the inverse electron demand Diels-Alder (IEDDA) click reaction for diagnostic and therapeutic pretargeting; an overall introduction to antibodies in nuclear medicine; and a review based on the role of click chemistry and its advances in recent years.</p>
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Fullerene Based Nanomaterials for Biomedical Applications
… and concentration of the Gd-based fullerenes. Click chemistry has been extensively used in functionalization due to the high efficiency and technical simplicity of the reaction. Appendix A describes a new type of Sc3N@C80 derivative conducted by employing the click reaction. The structure of …
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