Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1432 for “"cleavage"”.
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The Role of ATP and Cleavage Factor Phosphorylation in pre-mRNA 3' Cleavage Reaction
<p>The 3' end cleavage/polyadenylation (3' processing) is important in generating a functional messenger RNA (mRNA) transcript. It is long-known that ATP can significantly stimulate the in vitro cleavage of adenovirus type 2 L3 (Ad2L3) RNA substrate. Here, we used ATP analogs in structure-activity …
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Anchimerically Assisted Homolytic Bond Cleavage
Made available in DSpace on 2014-12-05T19:37:44Z (GMT). No. of bitstreams: 1 6104257.pdf: 9136630 bytes, checksum: ec6059f438cb384b3dcc9942728411ce (MD5) Previous issue date: 1961
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Restoring and enhancing Argonaute2-catalyzed cleavage
… to produce miR-451, a microRNA generated by a cleavage reaction analogous to slicing. This ability is due to a G-G mismatch within the fish miR-451 precursor, which substantially enhances its cleavage. This led to the surprising discovery that an analogous G-G mismatch ( or sometimes also a G-A …
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Mechanism of Permissive Cleavage Activity of TevCas12a
… the substrate. We call this activity permissive cleavage. TevCas12a activity is guide RNA dependent, but not guide RNA sequence specific, it can degrade any DNA substrate with a non-targeted guide RNA. Sequencing of the TevCas12a cleavage products with Oxford Nanopore revealed that most of the …
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DNA double-strand cleavage mediated by bleomycin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Party Politics in Intercivilisational Encounters : The Modernity Cleavage
… in Intercivilisational Encounters: The Modernity Cleavage Abstract The thesis presents an extension of the Lipset - Rokkan model of cleavage-based party politics. It employs concepts of civilisational analysis, particularly the concept of multiple modernities as devised by Shmuel Eisenstadt, to …
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In Vitro Characterization of Proglucagon Cleavage by PCI
… on the carboxy-terminal side of specific cleavage sites identified most commonly by dibasic residues and less often by tetrabasic and monobasic residues. Identification of a furin/propeptide convertase (furin/PC) family of endoproteases has led to in vivo and in vitro studies aimed at …
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Community Action: A Case Study in Racial Cleavage
Made available in DSpace on 2014-12-05T21:20:55Z (GMT). No. of bitstreams: 1 6206113.pdf: 18923260 bytes, checksum: a1939823f97f944d7a22c672fb7e9624 (MD5) Previous issue date: 1962
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Designed Bond Cleavage Reactions for Next-Generation Therapeutics
… project focuses on a metal-mediated amide bond-cleavage reaction from a pentenoic group by using Au salt (Na[AuCl4]) for prodrug activation in aqueous systems. Central to this strategy is a cyclisation step involving the formation of a 5-membered ring intermediate that undergoes rapid hydrolysis …
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Premature cleavage of ship plating under reversed bending
… such as accidents at sea or earthquakes. Since cleavage is more dangerous than ductile fracture, attention was focused on conditions controlling cleavage fracture. A careful inspection of damaged components of ships and structures damaged in the 1995 Kobe earthquake showed that fracture often …
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Catalytic antibodies for amide cleavage and prodrug activation
The first part of the thesis describes a novel approach to generate amide cleaving antibodies. Two haptens, O1 and O2, were designed and synthesized to create a hydrophobic pocket for an auxiliary nucleophile as well as elicit complementary basic/acidic side chain residues in the antibody combining …
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Marcus Theory Applied To Acetal Cleavage And Aldol Reactions
The acid catalyzed and uncatalyzed hydrolysis of the acetal 2,2-dimethoxypropane (DMOP) and the ortho ester trimethylorthoacetate (TMOA) have been studied in aqueous solution at 25{dollar}spcirc{dollar}C. Theoretical and experimental evidence have been found for a base catalyzed E2 mechanism of …
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Low Temperature Cleavage Fracture of Microalloyed Bainitic Plate Steels
Low temperature cleavage fracture behaviour was investigated using four experimental microalloyed bainitic plate steels. The four plate samples were produced by different thermomechanical processing (TMP) schedules and had yield strengths in the range 540 - 670 MPa. Microstructures were …
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Reductive cleavage of N-substituted benzenesulfonamides and p-sulfamylbenzoic acid
… the hope that information concerning the initial cleavage step might be discerned.</p>
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Nitrate Radical-Mediated Oxidative Cleavage of Olefins Using TiO2 Photocatalysis
… chemical transformations. Among these, oxidative cleavage has emerged as a critical process, enabling the conversion of olefins into high-value carbonyl compounds such as aldehydes and ketones. These compounds play an essential role in synthesizing polyamides, polyurethanes, and various other …
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Intrinsic Cleavage Inhibition by Thermophilic Type II-S Restriction Endonucleases
… sequence. These enzymes maintain complete cleavage promiscuity, allowing utilization in techniques such as Golden Gate assembly, Serial Analysis of Gene Expression (SAGE), and Restriction Endonuclease Protection, Selection, and Amplification (REPSA). However, laboratories generated evidence …
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Transition-Metal Complexes as Enzyme-Like Reagents for Protein Cleavage
In this thesis, metal-promoted hydrolytic cleavage of the amide bond in histidine-containing dipeptides, has been studied. Transition-metal complexes are emerging as new reagents for selective cleavage of unactivated amide bonds in proteins. Such complexes bind to the side chains of methionine and …
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