Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 89 for “"cleavable"”.
-
Towards Photoredox-Cleavable Prodrugs
… of photoredox-mediated photouncaging and photocleavable prodrugs, though further work will be necessary to prove its applicability in prodrugs.
-
The Development of Sulfatase-Cleavable Linkers for Antibody-Drug Conjugates
… to the success of an ADC. Although cathepsin-cleavable dipeptides are the most widely used linker motifs, they suffer from a number of key drawbacks, such as instability in rodent blood and poor aqueous solubility. First, this thesis describes the design, synthesis and evaluation of …
-
Polymer Deconstructability and Recyclability via Introduction of Cleavable Si−O Bonds
The synthesis of a new polysilylether via entropy-driven ring-opening metathesis polymerization (ED-ROMP) of cyclic bifunctional silyl ether-based monomers is reported. High molecular weight polymers (up to 100 k) with narrow dispersities were achieved at modest temperature. These polymers display …
-
A study of the C-terminus in prestin by designing cleavable constructs
… types of short peptides, flexible, rigid and cleavable linkers, into different positions in the C- terminus and tested prestin’s funtionality, self-interactions, and lateral mobility in the membrane. First, we inserted short peptides between the last trans-membrane domain and the STAS domain. …
-
Design and synthesis of acid-cleavable monomers for chemically degradable polymeric materials
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
-
Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures
… materials. Here, we report the design of cleavable monomers and cross-linkers for the synthesis of degradable materials with different polymer architectures. The first half of this thesis focuses on the design of new degradable bottlebrush and brush-arm star polymers (BASPs) via …
-
Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes
We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and …
-
Balancing Antitumor Efficacy and Safety Profile: α-Amanitin-Based Fc-Small Molecule Drug Conjugates for Targeted Prostate Cancer Therapy
… extension, and Amanitin as a toxin bearing a cleavable linker. This conjugate showed good in vivo efficacy; however, because of the low tolerability, the therapeutic index (TI) was low (=1). To increase the tolerability, this work focused on the unspecific uptake of the conjugates in healthy …
-
Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability
… (co)polymers (BBPs), featuring caspase-3-cleavable peptides linked to fluorogenic probes that provide a “turnon” signal upon enzymatic cleavage. The impacts of different architectural features of these polymers on enzyme access reveal insights into the interactions of enzymes with BBPs, …
-
Mass spectrometry of crosslinked peptides
… foundation for the later development of a UVPD-cleavable crosslinker (UCCL). Fourth, crosslinking MS was further advanced by introducing a cleavable moiety into the crosslinker reagent. This allowed for advanced acquisition regimes and showed promising results, especially for proteome-wide …
-
Synthesis and biological evaluation of structurally diverse indole-based analogues as inhibitors of tubulin polymerization and synthesis of drug-linker constructs cleavable by enzymes present in the tumor microenvironment.
… to drug-linker constructs featuring protease-cleavable short peptides. The most promising drug-linker constructs will be conjugated to PS-targeting betabodies in future studies. The potent payloads, KGP18 and KGP156, are capable of inducing tumor damage through two complementary and distinct …
-
Characterization of Erbb4 Expression In Osteosarcoma
… isoforms and two cytoplasmic isoforms. The cleavable juxtamembrane isoforms, Jm-a and Jm-d, can undergo proteolytic cleavage and produce an 80-kDa cytoplasmic fragment referred to as “p80,” which has been demonstrated to enhance cellular survival and malignant behavior in many solid tumors …
-
One-Carbon Bridge Stapling for use in Peptide-Drug Conjugates
… peptide. A model reactive oxygen species (ROS) cleavable linker with 7-hydroxycoumarin was analysed using fluorimetry and quencher studies, to confirm hydrogen peroxide dependent release. The same observation was determined for three cytotoxin ROS-cleavable conjugates. Finally, two PDCs were …
-
The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
… new therapeutic targets. 2. The development of cleavable stapled peptide-drug conjugates to target Pseudomonas aeruginosa Antimicrobial resistance (AMR) is a major healthcare threat, and Gram-negative bacteria such as Pseudomonas aeruginosa pose a significant therapeutic challenge. Antimicrobial …
-
Synthesis and Characterization of Responsive Poly(Alkyl Methacrylate) Topologies
Dimethacrylate monomers containing two cleavable tert-butyl ester groups were synthesized and utilized in the synthesis of star-shaped polymers. Star polymer coupling was achieved by reacting the living poly(alkyl methacrylate) using 2,5-dimethyl-2,5-hexanediol dimethacrylate (DHDMA) or dicumyl …
-
Metal Mediated Mechanisms of Drug Release
… covalently ligated to a protein by a palladium-cleavable linker. This chemistry was demonstrated by the conjugation of the anticancer drug doxorubicin to a tumour targeted anti-HER2 nanobody. The drug could then be delivered to cancer cells upon addition of a palladium complex. The second …
-
Small Molecules and Their Conjugates with Peptides: Chemical Strategies to Tackle Resistant Bacteria
… and how it could be targeted with two different cleavable peptide–drug conjugates. These conjugates aim to simultaneously release two independently-acting antimicrobial agents, selectively in a bacterial environment. To prepare these conjugates, a small-molecule antibacterial compound was …
-
Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer
… of NDV and generated a recombinant NDV (rNDV) cleavable exclusively by prostate specific antigen (PSA). The rNDV replicated efficiently and specifically only in prostate cancer (CaP) cells but failed to replicate in the absence of PSA. Further, PSA-cleavable rNDV caused specific lysis of …
-
Analysis and characterisation of an acylphosphine oxide photoinitiator
… is a new member in the group of well-known α-cleavable photoinitiators among which monoacylphosphine oxide (MAPO) is most recognised. These α–cleavable photoinitiators are characterised by low volatility and high solubility in acrylate monomers and they are very widely applied as curing agents …
Page 1 of 5