Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"clearance rate"”.
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Nebulized Hypertonic Saline-Triggered Increase in Mucociliary Clearance Rate is Mediated by the Nervous System
… airway lumen and, thus, increasing mucociliary clearance (MCC). However, recent research has also demonstrated that HTS-triggered increase in ASL height is mediated by the nervous system, whereby HTS stimulates sensory neurons to promote active secretion of ASL via airway epithelia. It has been …
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Development and application of a novel method to determine large very low density lipoprotein (VLDL1) kinetics
… (TG) and -apolipoprotein (apo) B production rates and the Intralipid-TG clearance rate (as a surrogate measure of CM clearance). Kinetic data obtained from this method agreed with values and relationships obtained from stable isotope methods. The protocol is relatively quick, inexpensive, and …
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Polycystic ovary syndrome : the effect of weight loss on intravenous triglyceride clearance and lipid profile
… on markers of insulin resistance, triglyceride clearance rate and lipid profile in obese patients with PCOS.
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Mechanism of lipid disorder in HIV infection: apolipoprotein-B kinetics, fat distribution, insulin resistance and adipocytokines in patients taking protease inhibitors or non-nucleoside reverse transcriptase inhibitors
… had mild dyslipidaemia. The apo-B fractional clearance rate (FCR) was reduced in the HIV positive groups. Peripheral fat was lower in treated patients and correlated with duration of therapy. There was a positive correlation between peripheral fat and apo-B clearance rate and a negative …
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Homicide Clearance in England and Wales: Understanding the National Decline
… is to critically explore the declining homicide clearance rate across England and Wales since 2011, and to identify what factors have contributed to this downturn. Homicide clearance is often used as a barometer of police effectiveness and a sustained decline in clearance can pose serious …
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A microfluidic mucosal airway model to study airway mucosal function and pathogenesis
Airway mucus hypersecretion or impaired clearance is one of the key pathophysiological features of airborne infection, allergy and severe respiratory diseases. As foreign particles enter the lungs, the airway becomes inflamed and excessive amount of mucus is generated in response. However, little …
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Magnetic resonance imaging contrast agents for chemical sensing
… environment of these areas once found. The fast clearance rate of contrast agents, in particular, makes quantitative assessment of local tissue with MR difficult. This thesis focuses on the development of solid MRI contrast agents designed for longterm, quantitative monitoring of local …
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Glucose clearance studies in lactating cows: influence of stage of lactation and ration composition
Glucose pool size (PS), pool space (PV) and clearance rate (CR) vere determined for eight first-lactation Holstein cows at three lactation stages [early (E) = 75-100 days, late (L) = 205-250 days, and dry (D) ]. A corn silage-based ration (15% CP, 22% ADP) was fed ad libitum during lactation and at …
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Devaluation and Solvability: The Quest for Factors Affecting Violent Crime Clearance
The U.S. violent crime clearance rate has gradually decreased since the 1990s, and current literature posits three main explanations—victim devaluation thesis, neighborhood devaluation thesis, and solvability perspective—for the decline. The literature on violent crime clearance, however, is …
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Anti-diabetic properties of GUH
… for a period of twelve weeks. Thereafter a separate groups of animals were then treated with GUH at 5 different dose levels, metformin or rosiglitazone for twelve weeks. Food intake, liquid intake, weights, blood glucose, and insulin were monitored throughout the treatment period. An intravenous …
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Exploring Police-Community Relations Through Homicide.
… relations influence the homicide clearance rate and cold case homicide investigations. Using a mixed-methods approach, it draws on two studies: in-depth interviews with stakeholders (police officers, victims’ families, and victim support workers) in Chicago, and a national survey …
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Modeling HIV-1 Infection and Immune Responses Under Drugs of Abuse
… associated with de creasing the viral mutation rate. The rapid replication of HIV may result in increased production of mutant viruses that can escape detection by the host’s immune system. This shows that the use of drugs of abuse can make it harder to effectively manage HIV infections. It is …
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Chickens from lines artificially selected for juvenile low and high body weight differ in glucose homeostasis and pancreas physiology
… insulin receptor are also conserved among vertebrate species, birds do not experience deleterious effects of chronic hyperglycemia as observed in mammals. Understanding avian glucose homeostasis, particularly in chickens, has both agricultural and biomedical implications. Improvement of feed …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… that modulate amyloid beta synthesis and clearance in the brain. Extensive evidence exists that both the isoform and amount of apolipoprotein E (apoE), an amyloid beta-binding molecule, influence amyloid beta aggregation and clearance from the brain. Therefore, studying how the molecular …
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An Affinity Threshold for Maximum Efficacy in Anti-PD-1 Cancer Immunotherapy
… combination of equilibrium and kinetic sorting strategies was used to both improve and reduce the affinity of a parental anti-PD-1 clone, 29F.1A12. We characterized the affinity of the antibodies using a number of methods, including ELISA, off-rate bead assays, and bio-layer interferometry, to …
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Essays in political economy
… ten years after the reform, the property crime rate was lower and the violent crime clearance rate was higher in departments operating under a merit system than in departments operating under a spoils system. I explore three possible channels: resources, police officers' characteristics and …
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Engineering antibodies for improved targeting of solid tumors
… by an inability of the antibodies to fully penetrate the tumor tissue, leaving large regions of untargeted and viable cells. The goal of this thesis is to understand the transport phenomena that contribute to poor antibody distribution in tumors, and engineer novel antibody variants with improved …
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The effects of microplastic and natural particles on the invasive mussel Mytilus galloprovincialis (Lamarck, 1819) and the native Choromytilus meridionalis
… in areas prone to sand inundation. Respiration rates, byssus production, clearance rate, body condition (BCI) and survival of mussels exposed to four concentrations of two particle types, polyvinyl chloride (PVC) and red clay were measured. A significant concentration effect was found in the …
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Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures
… in order to modulate its drug release and clearance rate (Chapter 1). After the introduction, we present the synthesis of boronic ester-crosslinked BASPs that selectively disassemble into bottlebrush fragments upon exposure to hydrogen peroxide, which is often elevated in diseased tissue …
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Integrating Taxonomic Meta-Analysis and Mussel Physiology to Assess Secondary Salinization in Appalachian Headwaters and Urban Streams
… animals in 78% of non-arthropod invertebrates, 68% of zooplankton, 62% of amphibians and insects, 56% of mollusks and crustaceans, and 51% of fishes. However, the diverse study designs and ionic concentrations hindered generalizable comparisons across taxa. My first objective was to …
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