Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"clathrin-independent"”.
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Understanding Membrane Curvature Sensing
… 3) domain and has recently been identified in a clathrin-independent endocytosis pathway, FEME (fast endophilin-mediated endocytosis), involved in the uptake of cell surface receptors. Endophilin recognises ligands via its SH3 domain, binding G-protein coupled receptors (GPCRs) directly in their …
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Regulation of Clathrin Mediated Endocytosis and Its Role in Cancer Progression
… to measure three different endocytic pathways: clathrin-mediated endocytosis, caveolae-mediated endocytosis, and clathrin-independent endocytosis and compared these activities in 29 independently isolated non-small cell lung cancer (NSCLC) cell lines to determine whether there were systematic …
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MOLECULAR MECHANISMS OF THE FORMATION OF ENDOCYTIC PATCHES AND THE INITIATION OF ACTIN POLYMERIZATION IN FAST ENDOPHILIN MEDIATED ENDOCYTOSIS
… Fast endophilin mediated endocytosis (FEME) is a clathrin independent endocytic pathway that is responsible for the uptake of numerous receptors, many of which are major drug targets, including the exclusive uptake of the β1-adrenergic receptor (β1-AR). Successful internalization of cargo via FEME …
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Analysis of Cellular Factors Involved in Adeno-Associated Virus Type 2 Entry
… mediates an alternate entry pathway that is clathrin-independent and caveolar-independent. We show that inhibitors of macropinocytosis, which did not inhibit the clathrin-dependent entry pathways, blocked the entry of AAV and HSPG as well as blocked AAV transduction. In cells that are …
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Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis
… acquisition. Macropinocytosis, a form of clathrin-independent endocytosis, is upregulated in TSC2-deficient cells. We performed a high-throughput compound screen utilizing a repurposing drug library. We identified that ritanserin, a diacylglycerol kinase alpha (DGKA) inhibitor, synergizes …