Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"clathrin coated vesicles"”.
-
Characterisation of the AP-3 adaptor-like complex
Clathrin coated vesicles were the first type of coated vesicle to be characterised. The coat consists of two components, clathrin and adaptor (or AP) complexes, the AP-1 complex is associated with the clathrin coated vesicles that bud from the TGN and the AP-2 complex is associated with the …
-
Conserved and Novel Properties of Clathrin-Mediated Endocytosis in Dictyostelium Discoideum
<p>The protein clathrin mediates one of the major pathways of endocytosis from the extracellular milieu and plasma membrane. Clathrin functions with a network of interacting accessory proteins, one of which is the adaptor complex AP-2, to co-ordinate vesicle formation. Disruption of genes involved …
-
Yeast Dynamin Functions with Clathrin at the Golgi
… dynamin family proteins work in concert with clathrin to facilitate not only receptor-mediated endocytosis, but also traffic from the Golgi to endosomes. In this study, the interdependency between Vps1 and clathrin was investigated. Subcellular localization of clathrin was at the Golgi, early …
-
cpg2 encodes a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
… of excitatory synapses, often in the vicinity of clathrin-coated pits. I further show that, through its C-terminal coiled-coil motifs, CPG2 binds to the actin cytoskeleton and to endophilin B2, a member of a family of proteins involved in membrane trafficking. RNAi-mediated knock-down of CPG2 …
-
Biochemical and genetic analysis of the adaptor protein SH3P7 : insights from a newly generated knockout mouse
… a huntingtin family member and new component of clathrin-coated vesicles, is characterized in greater detail. In resting B cells, Hip1R is constitutively bound to SH3P7. Stimulation of B cells with BCR-crosslinking-antibody or pervanadate-treatment, abolishes the interaction in a time-dependent …
-
Cellular Trafficking and Processing Pathways of the Alzheimer β/A4 Amyloid Precursor Protein
… was provided by the identification of APP in clathrin-coated vesicles, which mediate the transport of many proteins to endosomes. The subcellular distribution of APP was examined by microscopy and correlated with its biochemical processing. As shown by immunofluorescence microscopy of rat …
-
Down-modulation of the apoptosis receptor Fas and the EGF receptor by the adenovirus E3/10.4-14.5K proteins requires the concerted action of two distinct transport signals
… which select cargo for directed transport in clathrin-coated vesicles. FACS analysis of stable E3-transfectants expressing 10.4-14.5K mutant proteins revealed that residues contained within these putative transport motifs were essential for down-regulation of Fas and the EGFR in vivo. Receptor …
-
Proteomic analysis of the sorting machineries involved in vesicular traffic between the biosynthetic and endosomal compartments
… parallel trafficking pathways regulated by the clathrin adaptors AP-1A and AP-3 (Owen et al., 2004). Typical cargo molecules sorted along the AP-1A regulated pathway are mannose 6-phosphate receptors (MPRs) (Ghosh et al., 2003) or the gpI envelop glycoprotein of the Vesicular Zoster virus …