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Showing 1 to 20 of 30 for “"class switch recombination"”.

  1. Distinct isotype-specific factors for immunoglobulin class switch recombination.

    Limei. Ma (8000006)2001

    … isotype-specific factors for immunoglobulin class switch recombination.

    uic

  2. The Role of ZMYND8 in Immunoglobulin Class Switch Recombination

    Rosen, Daniel Benjamin

    <p>Class switch Recombination (CSR) also known as Immunoglobulin (Ig) Class switching is a genomic recombination/deletion reaction that diversifies the effector component of the antibody response but preserves antigen specificity. CSR is initiated by the enzyme activation induced cytidine deaminase …

    rockefeller Repository record

  3. Local somatic hypermutation and class switch recombination in allergic rhinitis

    Coker, Heather2004

    kings Repository record

  4. The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination

    Jean Guillaume, Sabine2022

    … isotypes through a process known as class switch recombination (CSR). In these cells, activation induced cytidine deaminase (AID) binds Gquadruplex (G4) switch transcripts, which serve as guide RNAs to target AID to the immunoglobulin heavy chain switch (S) regions in the DNA for CSR. …

    cuny Repository record

  5. C-terminal region of AID is required for efficient class switch recombination and gene conversion

    Sabouri, SomayehKyoto University2014

    kyoto Repository record

  6. Early divergent B cell differentiation during antibody responses

    Marshall, JenniferUniversity of Birmingham2009

    … follicular or GC responses and the amount of class switch recombination (CSR). The expression of phenotypic markers and switched antibody protein in parallel with gene array analysis and single cell real time RT-PCR in responding B cells was used to identify GC and plasmablast precursors and …

    birmingham Repository record

  7. Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis

    Li, Li2015

    … such as immunoglobulin heavy chain (IgH) class switch recombination (CSR), an important mechanism for antibody diversification and specification of immunoglobulin effector function during a humoral immune response in mammals. Through catalyzing ubiquitylation of the H2A-type histones …

    toronto-retro Repository record

  8. Transcription, Editing, and Switching of Antibody Genes

    Casellas, Rafael

    … J gene segments through a process known as V(D)J recombination. Because of its stochastic nature, V(D)J recombination is expected to create self-reactive specificities. In targeted animals carrying autoantibodies, these specificities were shown to be silenced by deletion, anergy, and receptor …

    rockefeller Repository record

  9. Regulation of Immunoglobulin Gene Diversification By Noncoding RNA's

    Teng, Grace

    … silencing. These mechanisms range from "classical" RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeatassociated small RNAs. Here, I describe the contribution of miRNA-mediated regulation to a specific case of gene expression …

    rockefeller Repository record

  10. Characterization of human IgA-inducing protein

    Mark Allen EndsleyThe University of Texas Medical Branch2009

    … maturation, but have also been implicated in class-switch recombination and B cell lymphoma survival. Recently added to this list of DC-derived factors effecting B cells is IgA-inducing protein (IGIP). Here we characterize production of IGIP by human DCs, and examine its capacity to induce IgA …

    utmb Repository record

  11. Altered Kinetics of Non-Homologous End Joining Mediated DNA Repair in Mouse Models of Aging and Leukemia

    Puthiyaveetil Abdulkader, Abdul GafoorVirginia Tech2012

    … their bone marrow differentiation and peripheral class switch recombination (CSR), thus lending them as a good model system in which to delineate the DNA repair mechanisms. To determine the effect of aging on NHEJ, B lymphocytes from old mice were analyzed. The results showed compromised DNA …

    vt Repository record

  12. The Role of 53BP1 in DNA Double-Strand Break Repair

    Bothmer, Anne Helen

    … the immune cell diversification reactions V(D)J recombination and Class Switch Recombination (CSR) require the formation of DSB intermediates, a process that is tightly controlled and strictly limited to developing B and T cells. CSR in B cells diversifies antibodies by joining DSBs between …

    rockefeller Repository record

  13. The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies

    Market, Eleonora

    … for somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. SHM alters the affinity of an antibody for its corresponding antigen by introducing point mutations within the variable region of the immunoglobulin (Ig) gene heavy chain locus. CSR replaces the Ig μ …

    rockefeller Repository record

  14. The role of human CD23 in lgE homeostasis & allergic disease

    Cooper, AliKing's College London2013

    … stimulated with IL-4 and anti-CD40 to induce class switching to IgE in vitro. mCD23 was up-regulated and sCD23 accumulated in the medium prior to IgE synthesis. IL-10 and IL-21 were shown to enhance IgE synthesis by increasing cell division and plasma cell differentiation. siRNA inhibition of …

    kings Repository record

  15. The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification

    Macaluso, Marc2016

    … of somatic hypermuntation (SHM) and isotype class switch recombination (CSR). AID is targeted to the immunoglobulin gene locus where it deaminates cytosines to generate uracil residues in DNA. This generates guanine-uracil (U:G) mismatch lesion which are recognized by uracil DNA glycosylase …

    uthsc Repository record

  16. 53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis

    Mirman, Zachary Kenneth

    … at programmed breaks generated during class switch recombination in the immune system. The role of 53BP1 in double strand break (DSB) repair outside of these three well-studied contexts is less clear, though it has been proposed that 53BP1 acts as a master regulator of so-called "DSB …

    rockefeller Repository record

  17. Characterization of Variable Region Structures and Antigen-Binding Properties of OxLDL-Specific Human Monoclonal Antibody Isolated from PBMC and Atherotic Plaques of Atherosclerosis Patients

    서, 창원2011

    … 86~98%. Evidence of somatic hypermutation and class switch recombination was also obtained by analyzing the local expression of mRNA transcripts encoding AID in the atherosclerotic plaque. CONCLUSION: The oxLDL-specific human monoclonal antibody Fabs which have 10~1000 folds higher affinities …

    ajou Repository record

  18. Single-Stranded Dna Scanning And Deamination With Single-Molecule Resolution

    Senavirathne, Padhuk Gamarala2013

    … initiation of somatic hypermutation (SHM), and class switch recombination (CSR), by the C deaminations in immunoglobulin genes. Activity of these enzymes requires scanning of single-stranded (ss) DNA substrates to locate deamination motifs and stochastically deaminate them to create mutational …

    wayne-thes Repository record

  19. B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets

    Pathmanandavel, KarrnanUNSW, Sydney2026

    … IL-4 and IL-21 in the regulation of IgE class-switch recombination (CSR). We furthermore show that naïve B cells from most IEI, including STAT3 HIES, do not exhibit an intrinsic propensity for IgE CSR in vitro. Aim 2 (Chapter 4) addressed whether IgE+ B cells exist in humans, and found …

    unsw Repository record

  20. Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation

    Fritz, Eric Luke

    … introduced into immunoglobulin (Ig) genes, and class-switch recombination (CSR), in which genomic constant regions are recombined to encode antibodies of different isotypes. Both of these processes require AID-catalyzed C-to-U lesions at the Ig loci, which are resolved to generate point …

    rockefeller Repository record

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