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Showing 1 to 2 of 2 for “"cladribine"”.
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N9 Alkylation and Glycosylation of Purines; A Practical Synthesis of 2-Chloro-2'-deoxyadenosine
… synthesis of 2-chloro-2'-deoxyadenosine (2-CdA, cladribine) was accomplished with an overall yield of 48% from inexpensive guanosine and 57% from 2,6-dichloropurine. 2-Chloro-6-(2-propylimidazol-1-yl)purine was prepared either from guanosine in a yield of 61% in 5 steps or from 2,6-dichloropurine …
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Purging e alte dosi di chemioterapia con reinfusione di cellule staminali autologhe in linfomi non Hodgkin follicolari resistenti/refrattari
… the pts underwent 3 cycles of subcutaneous Cladribine at a daily dose of 0,14-0,10 mg/Kg for Day 1-5 every 3-4 weeks. The conditioning regimen was based on Mitoxantrone 60mg/mq + Melphalan 180 mg/mq, followed by SC re-infusion 24-hours later and G-CSF starting 24 hours after re-infusion. In …