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Showing 1 to 20 of 36 for “"citrulline"”.
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Quantification and Molecular Characterization of Anti-citrulline Antibodies in Rheumatoid Arthritis
Autoimmune diseases are believed to result from the inability of the immune system to distinguish self and non-self. Rheumatoid Arthritis (RA) is a systemic autoimmune disease that leads to joint destruction and affects more than 1.5 million adults (Centre for Disease Control). Auto-antibodies …
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Citrulline metabolism in cultured fibroblasts : citrullinemia analysis and nitric oxide production
A citrullinemic fibroblast cell line was used in this study to investigate two biochemical pathways involving citrulline. In the first section, the genetic mutation responsible for the argininosuccinate synthetase (-ASS) deficiency (1-5% activity) in this cell line was investigated. PCR analysis of …
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Biochemical studies on trichohyalin : the origin of the citrulline-containing proteins in the hair follicle / by Joseph Attila Rothnagel
Offprints of the author's articles inserted
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The use of cultured cells with defects of citrulline metabolism in diagnosis and in the study of intercellular communication
Citrullinemia and argininosuccinic aciduria are two disorders resulting from defects in two consecutive enzymes of the urea cycle, argininosuccinate synthetase and argininosuccinate lyase. Fibroblast cell lines were derived from patients with these disorders and the diagnoses, which had been made …
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Effects of mid-gestational L-citrulline supplementation to twin-bearing ewes on umbilical blood flow, placental development, and lamb production traits
… useful when the maternal diet is compromised. L-citrulline was chosen for this work because of its long half-life in maternal circulation. This work utilized twin-bearing ewes with a moderate dietary energy restriction to assess the effects of mid-gestational L-citrulline supplementation on …
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Amino Acid Balance and Imbalance in the Pig With Emphasis on Urea-Cycle Metabolism and Interorgan Amino Acid Transfers
… fasting and amino acid imbalances. Supplemental citrulline replaced arginine for growth in pigs fed arginine-deficient diets whereas ornithine supplementation was without effect. Excess ornithine increased free ornithine and proline in liver, kidney and muscle whereas free citrulline increased …
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… sub-family of lasso peptides contain a citrulline post-translational modification which inspired reactivity-based screening for additional citrullinated natural products from bacteria. While ubiquitous in eukaryotes, deamination in bacteria is poorly characterized and exceedingly rare. …
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Genetic studies of mutants of Neurospora crassa lacking ornithine transcarbamylase
… confirmed Krebs' claim (1932) that ornithine and citrulline are precursors in the biosynthesis of arginine. With the characterization of more enzymes, there were indications that arginine biosynthesis was more complex than originally believed. When Jones, Spector and Lipman (1955) characterized …
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Characterisation of Nitric Oxide Synthase Activity in the Sea Anemone Aiptasia pallida and an Evaluation of Responses to Environmental Stress
… the conversion of 3H L-arginine to 3H L-citrulline (the citrulline assay). This assay was shown to be sufficiently sensitive for studies of this nature but was not optimised for use with cnidarian preparations. As a result, confidence in the accuracy of the generated assay results is …
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Unlocking thePadlock: Elucidation of Protein Arginine Deiminase 4 Function, Activity and Activation Dynamics
… of peptidyl-arginine to form peptidyl-citrulline in a variety of protein substrates. Over the past decade the importance of this post translational modification has become increasingly apparent as its putative roles in diseases becomes more evident. Enormous effort has been made towards …
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Investigating sensory characteristics and flavor profiles of ten cucumber cultivars using descriptive and sensory instrumental analysis
… with GC-MS for 26 amino acids and HPLC for citrulline and arginine. Key sensory attributes for cucumber included fresh, green, cucumber-like, crispy, sweetness, and juiciness, with significant differences (p≤0.05) in fresh, bitter, and crispy between 10 cultivars. UW05 and UW06 possessed …
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Regulation of satellite cells by extrinsic factors during recovery from exercise in horses
… differentiation. The influence of dietary L-citrulline, an amino acid that has the potential to influence SC activity and nutrient availability by its metabolism to L-arginine, was assessed during recovery from exercise in unfit adult horses. To model submaximal exercise, horses were …
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Discovery of novel pathways of microbial arginine biosynthesis
… transcarbamylation of ornithine to produce citrulline is one of the crucial steps in the pathway. This reaction is catalyzed by the enzyme ornithine transcarbamylase (OTC). The transcarbamylases family of enzymes belongs to the carboxyl- and carbamoyltransferases group, EC 2.1.3, a family …
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An investigation of Porphyromonas gingivalis peptidylarginine deiminase: a putative virulence factor in an animal model of inflammation.
… enzyme that converts peptide-bound arginine to citrulline. A relationship between human PADs and chronic inflammatory diseases has been proposed. Citrullinated a-enolase is a candidate auto-antigen in rheumatoid arthritis. Vimentin and fibrin are also likely target proteins in disease …
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Vitamin D Inhibits Expression of Protein Arginine Deiminase 2 and 4 in Experimental Autoimmune Encephalomoyelitis Model Of Multiple Sclerosis
… modification of arginine peptide residues to citrulline. The pathogenesis of MS is poorly understood, though vitamin D deficiency is a well-associated risk factor for developing the disorder. Using the experimental autoimmune encephalomyelitis (EAE) model of MS we demonstrate vitamin D …
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Kinetic Characterization of the Protein Arginine Deiminase Family: Mechanistic and Inhibition Studies
… modification of peptidyl-arginine to peptidyl-citrulline in numerous protein substrates. This modification results in numerous physiological and pathophysiological changes that are believed to play a significant role in the onset and progression of several diseases, e.g., cancer, multiple …
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The Elasmobranch-Microbe Relationship: Trimethylamine n-oxide Synthesis, Urea Hydrolysis, and Microbe-Osmolyte Interactions in the Atlantic Stingray, <i>Dasyatis sabina</i>
… benzoic acid, arginine, creatinine and L-citrulline. Also observed was significant down-regulation of CPS III expression, suggesting that urea production decreased in antibiotic-treated individuals. My findings suggest that elasmobranch osmoregulation is robust to microbiome perturbation …
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Development of Novel Small-Molecule Therapeutics for Multiple Sclerosis
… on myelin structural proteins to neutral citrulline variants. Hypercitrullination disrupts key ionic interactions between myelin proteins and lipid bilayers that are necessary to maintain compaction within the multi-layered myelin sheath. Thus, myelin hypercitrullination reduces myelin …
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Generation of nitric oxide and its protective and toxic actions in the gastrointestinal tract
… converted exogenous arginine to ornithine and citrulline. This metabolism of arginine was not affected by a range of NO synthase inhibitors, but was reduced by the arginase inhibitors NG-hydroxy-L-arginine and L-ornithine. Thus, the predominant pathway of arginine metabolism involves arginase …
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EFFECTS OF RED BLOOD CELLS ON NITRIC OXIDE BIOACTIVITY
… is an enzyme for converting L-arginine to NO and citrulline. Arginase as another enzyme converts L-arginine to urea and L-ornithine. Nor-NOHA as arginase inhibitor is supposed to block the arginase pathway so that increase NO production. However, our data suggest that nor-NOHA reacts with …
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