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Showing 1 to 2 of 2 for “"cisplatin analogue"”.
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Synthesis, Characterization, And Rna Reactivity Of Amino-Acid-Linked Cisplatin Analogues
… diversity. The well-known anticancer drug cisplatin was previously applied as a chemical probe of rRNA structure to determine solvent accessible purines (guanosine) in vivo and in vitro. Cisplatin accumulates faster on RNA than DNA, with less chance of repair. As such, designing new …
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Photo-cross-linking and identification of nuclear proteins that bind to DNA containing a site-specific adduct of cis-[Pt(NH₃)(N-6-aminohexyl)-4-benzophenonamide)CI₂]
cis-Diamminedichloroplatinum(II), or cisplatin, is the most successful cancer drug ever discovered. It has been used for over 30 years in the treatment of several types of malignancies, with the highest success rates in testicular cancer patients. Despite the triumphs of this drug, the exact …