Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"cis-regulatory regions"”.
-
Inferring the properties of transcription factor regulation
The regulatory targets of transcription factors are costly to directly detect using existing technologies. Many computational models have thus been developed to infer the genes targeted by TFs using gene expression profiles, position weight matrices modeling TF protein binding, histone …
-
Regulation of flt3 gene expression in haematopoietic and leukaemic stem cells
… HSC and leukaemic cell lines, I locate several regulatory elements in the \(flt3\) locus by DNaseI mapping and have characterized their epigenetic environment. Analysis of the methylation and acetylation status of histones H3 and H4 around \(flt3 cis\)-regulatory regions highlights a distinct …
-
INVESTIGATING THE BASES OF THE SPECIFICITY OF THE RESTRICTOR COMPLEX FOR THE TERMINATION OF NONCODING TRANSCRIPTION
… initiation occurring at the tens of thousands of cis-regulatory regions in the genome can be detrimental to the normal functioning of the cell. Several transcription termination mechanisms act to keep the initiation of non-productive transcription in check. The Restrictor complex, composed of the …
-
Transcriptional regulation of adipose insulin resistance
… analysis of the experimentally identified cis-regulatory regions, we identified existing and novel trans-regulators responsible for adipose transcriptional regulation. Furthermore, by comprehensive pathway analysis of the in vitro models and mouse models, we identified aspects of in vivo …
-
Organ-specific regulation and molecular evolution of the maize pericarp color1 gene
… by the p2 coding sequence, while the flanking p1 regulatory sequences remained largely preserved. The red pericarp color specified by P1-rw1077 suggests that the p1- and p2-encoded proteins are functionally equivalent as regulatory factors in the flavonoid biosynthesis pathway. Sequence analysis …
-
Investigating the transcription factor landscape of the squamous subtype of pancreatic ductal adenocarcinoma
… of PDAC, and understanding how they regulate cis-regulatory regions and enhancer landscapes to maintain the PDAC squamous subtype. A proteomics approach developed within the lab called RIME (Rapid Immunoprecipitation and Mass spectrometry of Endogenous proteins) was used to identify the …
-
Regulation of segment polarity genes in the head region of different arthropods
… based on anterior head segment-specific cross-regulatory interactions among segment polarity genes (Gallitano-Mendel and Finkelstein, 1997). So far it remains unclear how the establishment of the procephalic segment polarity gene expression is controlled, although a functional input from the …
-
Identification of Drosophila heart-specific Cis-Regulatory Modules under Hox control
… aim of our work is to isolate the heart-specific cisregulatory sequences of abd-A direct target genes, the realizator genes granting heart identity. In each segment of the heart, four pairs of cardiomyocytes (CMs) express tinman (tin), homologous to NKX2-5, and acquire strong contractile and …
-
Genesis of the human germline
… and careful epigenomic characterisation of cis-regulatory regions at key steps during the in vitro model. To determine the regulation of the transient gain and loss of competence for germ cell fate, I re-engineered a CRISPR toolkit for activation and inactivation to test candidates for germ …
-
Albumin Transcriptional Regulation
… elements. Based on these studies, multiple cis-acting DNA regulatory regions were elucidated and the cognate proteins which interact with them characterized and where possible their identity determined. It was found that the promoter proximal -156 nucleotides of the rat albumin gene were …