Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"cis-elements"”.
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Analyzing the effects of Cis-elements and trans-factors on the stability of the Gal1 mRNP
The highly dynamic and nonrandom spatial organization of the eukaryotic nucleus plays an important role in the regulation of gene expression. For example, in S. cerevisiae, several conditionally expressed genes relocate to the nuclear periphery upon activation. Moreover, these genes can be retained …
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Regulation of Gene Transcription by Estrogen Receptor Alpha: The Role of Cis Elements and Trans -Acting Factors
The differential recruitment of coregulatory proteins to DNA-bound ERalpha plays a critical role in mediating estrogen-responsive gene expression. We previously isolated and identified retinoblastoma-associated proteins 46 (RbAp46) and 48 (RbAp48), which are associated with chromatin remodeling, …
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Characterization of Transcriptional Components in Methanocaldococcus Jannaschii: An Integrative Study of Archaeal Basal Transcription Factors and Putative Cis Elements
… footprinting to investigate the putative cis elements in M. jannaschii. Regions upstream of orthologous genes from four related methanococcal genomes were collected and analyzed for conserved motifs. This method was applied to identify putative rRNA promoter, and revealed novel elements …
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Identification of the RNA Cis-Elements that Interact with SRp30a to Regulate the Alternative Splicing of Caspase 9 Pre-mRNA
… RNA trans-acting factors with these possible RNA cis-elements revealed the specific binding of an approximate 66, 56, 45, and 38 kDa protein/protein complex to these sequences. A previous application of RNAi technology to downregulate SRp30a in A549 lung adenocarcinoma cells induced an …
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In silico identification of genes regulated by abscisic acid in Arabidopsis thaliana (L.) Heynh.
Abscisic acid (ABA) is a major plant hormone that plays an important role during plant growth and development. During vegetative growth ABA mediates (in part) responses to various environmental stresses such as cold, drought and high salinity. The response triggered by ABA includes changes in the …
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Isolation and characterization of latex-specific promoters from Papaver somniferum L.
… LSPs were sequenced and analyzed for regulatory elements using the Plant cis-acting regulatory DNA elements database, PLACE (http://www.dna.affrc.go.jp/PLACE). Knowledge of the cis-elements and regulatory regions of LSPs would serve as a tool for metabolic engineering of poppy alkaloids. …
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Regulation of Gene Transcription by Estrogen Receptors Alpha and Beta: DNA Binding, Tethering, and Coregulatory Protein Recruitment
Combining various cis-elements and coregulatory proteins to regulate gene expression may allow for differential expression of the gene under different cell environments and physiological conditions. These studies will advance our understanding of the complex mechanisms by which ERalpha is able to …
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Modeling and Analysis of Regulatory Elements in Arabidopsis thaliana from Annotated Genomes and Gene Expression Data
Modeling of cis-elements in the upstream regions of genes is a challenging computational problem. A set of regulatory motifs present in the promoters of a set of genes can be modeled by a biclique. Combinations of cis-elements play a vital role in ascertaining that the correct co-action of …
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Structure and Function Analysis of a Plant Transcription Activator
… mosaic virus 35S promoter is composed of several cis-elements, each of which confers a different expression pattern in transgenic tobacco. One such cis-element, activation sequence (as)-1 (-83 to -63) mediates preferential expression in root. The element contains a tandem repeat of the motif …
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Elucidation of Jasmonate-Responsive Promoter Elements in the Calmodulin-Like Gene CML39 in Arabidopsis
… predict a large number of putative JA-responsive cis-elements within the CML39 promoter. Deletion analysis of CML39 promoter fragments in planta reveals that some cis-elements respond in a tissue-specific manner. Analysis of transgenic MYC2 loss-of-function (myc2) mutants demonstrates that MYC2 – …
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An investigation of the mechanism of PAX7 mediated oncogenesis via in silico and in vitro biology
… This was achieved by: Systematic searches for cis conserved sequences within PAX7 intronic regions, which may be implicated in aberrant PAX7 expression in tumours; Comparison of conserved putative cis elements in human, mouse, chick and zebrafish PAX7/Pax7 homologues to identity the most …
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Function and Regulation of Xylem Cysteine Protease 1 and Xylem Cysteine Protease 2 in Arabidopsis
… water-conducting system, the tracheary elements of the xylem, is required to sustain plant growth and development. Tracheary element formation is dependent on many biological processes terminated by programmed cell death and cellular autolysis. The final two processes are probably …
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Identification, improved modeling and integration of signals to predict constitutive and altering splicing
(cont.) manipulation of intronic elements that enables fish genes to be spliced properly in mammalian cells; (iii) A computational analysis using EST data, genome sequence data, and microarray expression data of tissue- specific alternative splicing is conducted, which distinguishes human brain, …
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The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion
… We used Tcrb and Tcra alleles which lack various cis-elements (e.g. enhancers and promoters) and terminate transcription. By comparing nucleosome organization and histone octamer occupancy, we found that accessible alleles are characterized by lower histone octamer occupancy and in some cases …
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Hierarchy and CIS-Regulation in Drosophila Segmentation: Rules for Pattern Formation and Clues to Evolution
… few systems is it possible to analyze the global cis-regulatory structure of developmental transcription networks. One system where this is in principle possible is segmentation in Drosophila melanogaster, although to date such an undertaking has not been attempted. Here using computational …
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Transposable prophage Mu exists as an independent chromosomal domain in E. coli
… A model is proposed that by employing its cis-elements to create a domain barrier for segregation and compaction of its genome, the large selfish DNA element Mu profits from the transposition-ready arrangement of its ends, while simultaneously providing a fitness advantage to the host.
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PLANT TOLERANCE TO DROUGHT: MODULATION OF TRANSCRIPTION FACTORS
… analysis and some DOF-binding sites, fundamental cis-elements for the specific activity of this promoter in guard cells were identified. Through analysis of transegnic plants carrying the AtMYB41 promoter fused to a reporter gene specific response to drought stress was confirmed.
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Multiscale dissection of bacterial proteome optimization
… the development of analytical tools and precision measurement platforms spanning biological scales, we found evidence of optimization in bacterial gene expression programs. We compared protein synthesis rates across distant lineages and found tight conservation of in-pathway enzyme …
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SEQUENCE ELEMENTS ESSENTIAL FOR RNA EDITING IN CHLOROPLASTS
… this in vitro assay, the essential sequence elements for editing were delimited to a region containing sequences of rpoB that are shared with two other editing sites. Wild-type substrates were edited to a greater extent in vitro compared to substrates with nucleotide differences in the common …
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