Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cis-Regulatory sequence"”.
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Dissecting genetic determinants of transcription factor activity
… gene expression levels depend on their cis-regulatory sequence bound by TFs and condition-specific regulatory activity of TFs determined by its modulators through interaction with cofactors or signaling molecules. This thesis consists of two parts that related to the overall goal of …
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The interaction of promoter chromatin architecture with the cell cycle regulates transcription activation kinetics
The relationship between regulatory trans-factors binding a gene's cis-regulatory sequence elements and the transcriptional output of that gene is fundamental to even the most complex network behaviors such as metabolism and differentiation. In eukaryotes, chromatin dynamics on gene promoter …
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Evolution of the ZRS and the Regulation of SHH Expression in the Forelimbs of Bats.
… in the limb is regulated by a long-distance cis-regulatory sequence called the ZPA-regulatory sequence (ZRS). Mutations in the ZRS are known to result in limb deformities in humans, mice and cats. I investigated whether conserved mutations occurring in the bat ZRS are the cause of the change …
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Computational modeling of gene expression from regulatory sequences
… regulation of gene expression is dictated by regulatory DNA sequences, often called cis-regulatory modules (CRM; also known as “enhancer”), that contain specific binding sites for regulatory proteins (transcription factors, TF). The assembly of TFs bound on a CRM drives the desired expression …