Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"circulating tumour cells"”.
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Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
… predict the metastatic propensity of the primary tumour. However, genetic testing currently requires biopsy of the eye which can lead to serious complications including permanent blindness. Therefore, an alternative source of primary tumour genetic material is needed to avoid these complications. …
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Telomerase : a tumor marker in the peripheral blood of colorectal cancer patients
… fact strongly suggests that the dissemination of circulating tumour cells (CTC) occurs early in the disease process. The first clinical results obtained suggest that CTC detection and enumeration can be used to estimate prognosis and may serve as an early marker to assess anti-tumour activity of a …
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Identification of intravasation sites for metastatic biomarker development
… metastatic progression is the ability of cancer cells to breach the endothelial basement membrane and enter the vasculature. It has long been believed that the process of intravasation is preceded by local invasion, and yet, several studies have detected circulating tumour cells at earlier …
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Optimisation of the isolation and identification of circulating melanoma cells
… of treatment response and disease progression. Circulating tumour cells (CTCs) are released into the bloodstream by the tumours within a patient, this being a key step in melanoma spread. Since CTCs can be detected in the blood of metastatic melanoma patients, these cells can be used as a …
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Mechanisms of Metastatic Spread of Breast Cancer to the Brain
… breast cancer (TNBC), in which the tumour cells lack estrogen and progesterone receptors, and the HER2 protein, accounts for approximately 15% of all breast cancers and tends to have a younger onset and higher metastasis risk compared with other breast cancer subtypes. It also has …
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Investigating a novel combination treatment of androgen deprivation therapy, pelvic external beam radiotherapy and radium-223 dichloride in the management of hormone sensitive prostate cancer metastatic to bone
… leucocytes as markers of bone marrow dosimetry. Circulating tumour cells showed no signal of utility as a biomarker of response.</p><p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height: normal"> </p><p class="MsoNormal" …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… Currently, histopathological evaluation of tumour biopsies is the gold standard in clinical practice with the purpose of evaluating specific biomarkers to predict therapeutic response. However, this is invasive, and associated complications may occur. Liquid biopsy is a minimally invasive …