Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"circulating tumor DNA"”.
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Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA
… at the transcriptome level across breast tumors and the expression of individual isoforms was correlated to molecular subtypes, protein expression of clinical markers, and cancer stem cell (CSC) phenotypes in breast tumors and cell lines. The CD44S isoform was associated with expression of …
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Surface Plasmon Resonance Imaging Biosensors for Cancer Diagnosis: Detection of Circulating Tumor DNA
… to ensure the hybridization reaction of PNA-DNA complexes. The spatially controlled immobilization of PNA probes has been obtained by injecting PNA wild-type and PNA mutated solutions into a microfluidic system coupled to SPR sensor chip. The extremely low concentration of genomic DNA …
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Qualify Microplate Reader’s Specification and Establish the Acceptance Criteria for Modified PicoGreen Kit in Measuring cell-free DNA Concentration in Clinical Laboratory
<p>Cell-free DNA (cfDNA) is an emerging biomarker that researchers are utilizing to detect diseases in patients, allowing physicians to accurately diagnose and treat patients at the individual level. A few applications that utilize cfDNA to detect diseases in IVD (in-vitro diagnostics) are …
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Non-Invasive cancer detection: computational applications in liquid biopsy and radiomics
… of current methods in comprehensively analyzing circulating tumor DNA (ctDNA), particularly at low ctDNA fractions, and introduces novel tools and strategies to enhance the sensitivity and specificity of ctDNA analysis. The first part of the thesis focuses on the development of Synggen, a tool …
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Somatic Mutation Detection in Leukemia-Derived Circulating DNA: Utility in Monitoring Clonal Dynamics and Disease Response in Pediatric Acute Lymphoblastic Leukemia
… diagnostic clone. Somatic mutation detection in circulating-tumor DNA (Ct-DNA) offers a new venue for non-invasive studying of genetic heterogeneity and tracking clonal dynamics throughout therapy. Here, we employ targeted Next-Generation Sequencing (NGS) using a specifically designed ALL custom …
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Multi-Modality Plasma-Based Detection of Minimal Residual Disease in Triple-Negative Breast Cancer
… recurrence to death. Detecting the presence of tumor in patients who are technically “disease-free” after neoadjuvant chemotherapy and surgery as early as possible might be able to predict recurrence of patients, and then provide timely intervention for additional therapy. To this end, I applied …
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ANTIBODY-DRUG CONJUGATES FOR THE TREATMENT OF BREAST CANCER.
… patients with HER2DX low-risk versus high-risk tumors. We also evaluated real-world outcomes among 191 patients with metastatic breast cancer. Herein, we demonstrate that T-DXd is associated with relevant real-world activity, with a time-to-next treatment of 9.1 months (range: 7.6 – 10.4) and an …
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Genetic Evolution and Prognostic Determinants of Pancreatic Cancer On Longitudinal Liquid Biopsies
… the lowest 5-year survival rates amongst solid tumors. As early detection of PDAC is unusual and typically incidental, most patients present with locally advanced and metastatic disease where effective therapeutic strategies remain a significant unmet need. Specifically, surrogate biomarkers for …
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Cell-Free Dna Sequencing In Multiple Myeloma
… both in acute and long-term settings. Cell-free DNA, DNA fragments which are released into circulation as a part of normal cellular turnover, is a useful and dynamic biomarker in cancer patients due to the presence of circulating tumor DNA (ctDNA), which is readily identified using next …
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A Method for Identification of Pancreatic Cancer through Methylation Signatures in Cell-Free DNA
… it can spread throughout the body. Evaluation of circulating cell-free DNA (cfDNA), specifically, detection of circulating tumor DNA (ctDNA), is being explored as an approach for non-invasive ‘liquid biopsy’ that can be deployed widely and cost-effectively to screen for early signs of disease. DNA …
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Amplifying signals in the tumor microenvironment for drug development and diagnostics
… which increasingly involves genomic profiling of circulating tumor DNA (ctDNA) molecules in liquid biopsies such as blood. Despite the promise offered by these innovative therapies and monitoring tools, their broad integration into clinical practice faces important challenges. Widespread adoption …
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Decoding the RNA cargo of plasma-derived extracellular vesicles in metastatic castration-resistant prostate cancer
… by capturing multiple molecular components circulating in body fluids, such as circulating tumor cells (CTCs), cell-free DNA (cfDNA), cell-free RNA (cfRNA) and extracellular vesicles (EVs). EVs are nanoscale structures surrounded by a lipid bilayer. They carry a rich molecular cargo that …
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Detection and monitoring of treatment resistance in metastatic cancer through non-invasive DNA methylation-based biomarkers
This work focuses on empowering plasma circulating tumor DNA (ctDNA) analysis, as a non-invasive approach for precision oncology, with applications ranging from early detection and minimal residual disease (MRD) assessment to dynamic monitoring of treatment response and molecular profiling in …
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Circulating tumour DNA: A non-invasive biomarker for melanoma
… The detection and analysis of mutant specific circulating tumour DNA (ctDNA) is an emerging tool for detection of residual disease and for prognosis and monitoring of different cancers (Bettegowda et al., 2014; Dawson et al., 2013; Gray et al., 2015; Spindler et al., 2012). There is however, …