Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"circulating biomarkers"”.
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Identification of Tissue and Circulating Biomarkers For Premalignant and Malignant Lesions
… qPCR have revolutionized the identification of biomarkers in the epidemiology field. In response to the vast amount of data generated from high-throughput technologies, novel inventions in the computer sciences fields have been applied to analyze these data. The current study demonstrates the …
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Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
… is usually based on exclusion using blood-based biomarkers for cell injury. Currently used chemistry parameters lack sensitivity, specificity and prognostic capability. More importantly, they provide little insight into the underlying mechanistic basis of DILI hindering stratification and …
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The effect of weight loss on circulating biomarkers of brain health and executive function
Obesity is associated with deficits in cognitive function, particularly within the domain of executive function (EF). EF refers to higher order cognitive processes that regulate our ability to sustain attention, inhibit subconscious tendencies, remember and manipulate information for immediate use, …
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Identifying circulating biomarkers in a cohort of hypercholesterolaemic patients with statin intolerance from Gauteng, South Africa
… death worldwide. Dyslipidemia, defined by high circulating levels of atherogenic apoB-containing lipoproteins, contributes significantly to the increasing burden of cardiovascular morbidity and mortality. At public health care institutions, in South Africa, simvastatin and atorvastatin are the …
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The relationship between circulating biomarkers of nitric oxide and endothelin-1 and hemodynamic function in obstructive sleep apnea
… study was to assess the relative importance of circulating biomarkers of ET-1 and NO in hemodynamic function in OSA patients. Potential production of ET-1 by circulating mononuclear cells was also measured to assess their contribution to plasma ET-1 levels. Biomarker levels before and after 12 …
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The Performance of Circulating Biomarkers in the Prediction of Response to Neoadjuvant Therapy in Patients with Oesophago-gastric Cancer
… and potentially curative surgery. Levels of circulating biomarkers M2-Pyruvate kinase, alkaline phosphatase, CA19-9, CEA and CA 72-4 were measured in patients before and after administering the first cycle of chemotherapy. Binary logistic regression analysis was performed to assess the …
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LIQUID BIOPSY IN GLIOBLASTOMA (GBM)CHARACTERIZATION OF PLASMA EXTRACELLULAR VESICLES CONCENTRATION, SIZE AND CARGO FOR NON-INVASIVE GBM DIAGNOSIS, MONITORING AND IDENTIFICATION OF CIRCULATING BIOMARKERS
… the identification of potential companion biomarkers to implement the specific diagnosis of GBM and its longitudinal monitoring.
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Predicting the risk of progression in patients with thoracic aortic aneurysm
… work has examined a range of easily quantifiable circulating biomarkers in a cohort of 50 patients with aneurysms of the arch and descending thoracic aorta. I have described within this thesis various obstacles (logistical and biological) to identifying biomarkers of aneurysm progression. Despite …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… Recently there has also been growing interest in circulating biomarkers such as serum neurofilament light chain as they are easier to obtain from patients than imaging markers and as they can be centrally computed also in multicenter trials. The thesis aim is to evaluate imaging as well as …
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Identification and Utility of Dna In Exosomes
… a majority of cancers due to a lack of sensitive biomarkers or numerous limitations associated with current diagnosis strategies. Approaches to develop “liquid biopsies” by detecting tumor cells or DNA in the blood have led to several breakthroughs and create the potential for non-invasive, …
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Functional Imaging to enable more accurate localisation and characterisation of prostate tumours
… and spectroscopy. In the absence of validated circulating biomarkers, only functional imaging currently offers the potential for further improvements in lesion detection and characterisation, with the additional advantages of providing whole gland coverage of the prostate and being …
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Evaluation of miR-497 & miR-219 as non-invasive biomarkers for meningioma and glioma
… and prognosis. However, there is a dearth of circulating biomarkers with clinical value for meningioma diagnosis and classification. Circulating miRNAs have shown potential as cancer biomarkers in various tumours. This study evaluated specific miRNAs, miR-497 and miR-219, as convenient and …
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Genomics of lipid metabolism: Identification of genetic determinants of lipid metabolites and the effect of perturbations of lipid levels on coronary heart disease risk factors
… responsible for 50% of the total disease burden. Circulating lipids are strongly and linearly associated with risk of CHD; however, despite considerable efforts to demonstrate causality, available evidence is conflicting and insufficient. Study of the underlying metabolic pathways implicated in …
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microRNAs in Uveal Melanoma: in vivo findings and computational analysis
… poor prognosis. The role of miRNAs as potential biomarkers in UM patients has drown increasing attention and recent computational analyses have shown the prognostic significance of a cluster of deregulated miRNAs in UM patients. Purpose: The aim of the study was to assess whether the evaluation …
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Amplifying signals in the tumor microenvironment for drug development and diagnostics
… which increasingly involves genomic profiling of circulating tumor DNA (ctDNA) molecules in liquid biopsies such as blood. Despite the promise offered by these innovative therapies and monitoring tools, their broad integration into clinical practice faces important challenges. Widespread adoption …
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Novel imaging and blood biomarkers in acute aortic syndrome
… tomography and computed tomography (PET/CT) and circulating biomarkers in patients with acute aortic syndrome. METHODS: We performed 18F-sodium fluoride PET/CT in 56 patients with aortic dissection, intramural haematoma or penetrating aortic ulcers and 20 healthy controls. First, we characterised …
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Implementation of global miRNA biomarker discovery in human plasma
… diagnostics and identification of novel biomarkers. Small non-coding RNAs, specifically miRNAs, have been shown to exist extracellularly and are stable in biofluids, including blood and urine. The expression profile of extracellular miRNAs is also altered in a number of diseases making …
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IMPACT OF STRESS CARDIAC COMPUTED TOMOGRAPHY MYOCARDIAL PERFUSION ON DOWNSTREAM RESOURCES AND PROGNOSIS IN PATIENTS WITH SUSPECTED OR KNOWN CORONARY ARTERY DISEASE: A MULTICENTRE INTERNATIONAL STUDY - THE CTP-PRO STUDY
… and outcomes. The purpose of the substudy on circulating biomarkers is to identify, in the population of patients evaluated with CCTA, transcriptional biomarkers in peripheral blood of different CAD subtypes, with the aim of refining clinical decision making. Methods: CTP-PRO study is a …
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Single-molecule diagnostics to support curative interventions for tuberculosis and HIV
… (Simoa) digital ELISA that can diagnose TB from biomarkers in urine. Our assay is highly sensitive, as demonstrated in diverse cohorts totaling approximately 600 individuals. Simoa is a robust and widely used platform, but its accessibility is limited because it relies heavily on advanced …
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