Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"circular permutation"”.
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Graph Labelings
… non-crossing chords. A book embedding is a circular permutation of the vertices together with a partition of the edges into pages. The pagenumber t (G) is the minimum number of pages in a book embedding of G. We present a general construction showing $t(K\sb{m,n}) \leq \lceil(m + …
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DNA Bending by Steroid Receptors
… to transcriptional activation. We have used circular permutation analysis to determine the degree of DNA bending induced by binding of the GR DNA binding domain (DBD), the human PR DBD, PR-A:A and PR-B:B homodimers, and PR-A:B heterodimers to the HRE. We find that PR-A:A, PR-B:B and PR-A:B …
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Metalloprotein engineering with unnatural amino acids: application in functional heme-copper oxidase and azurin
… proteins, has Greek key β barrel scaffold. Circular permutation, a method that changes amino acid sequence of a protein with little perturbation to its three dimensional structure, was carried out in azurin. The resulting mutants were characterized structurally and spectroscopically.
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Studies of lipoic acid and biotin metabolism in bacteria and higher eukaryotes
My PhD research focus has been the study of lipoic acid and biotin metabolism in several bacteria. Lipoic acid and biotin are essential enzyme cofactors found in all three domains of life. Both molecules function only when covalently attached to key metabolic enzymes, 2-oxoacid dehygrogenase (OADH) …