Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"circular RNA"”.
-
Synthetic circular RNA for protein expression
Messenger RNA (mRNA) has broad potential for therapeutic and engineering applications. One fundamental limitation of mRNA is its relatively short half-life in biological systems, effected in part by rapid exonuclease-mediated degradation upon delivery. Circular RNA (circRNA), a type of …
-
THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… influencing macrophage function during injury. Circular RNAs are newly discovered non-coding RNA generated from protein-coding genes ubiquitously expressed in mammalian tissue, highly conserved among species, and recently implicated in the possible regulation of macrophage activation. However, …
-
The Investigation of the SKA3 Circular RNA Role in the Ovarian Cancer Progression
Circular RNAs (circRNAs) are becoming increasingly more recognized in cancer biology as novel biomarkers due to their high stability as well as tissue- and developmental stage-specific expression. Despite massive improvements made in treatments, ovarian cancer (OC) still is considered one of the …
-
Investigation of the Polyprimidine Tract-Binding Protein-Associated Splicing Factor (PSF) Domains Required for the Hepatitis Delta Virus (HDV) Replication
… (HDV), composed of ~1,700nt, is the smallest circular RNA pathogen known to infect humans. Understanding the mode of replication of HDV implies on investigating the host proteins that bind to its genome. The polypyrimidine tract-binding protein-associated splicing factor (PSF), an HDV …
-
CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS
… of drug. In this dissertation we will examine circular RNA (circRNA) dysregulation following a rodent model of heroin self-administration and characterize a novel circRNA pathway regulating opioid induced neuroadaptations. We identified 76 circRNAs regulated by heroin self-administration, of …
-
ROLE OF CIRCULAR PVT1 IN ISCHEMIC HEART FAILURE
Circular RNAs (circRNAs) are involved in the pathogenesis of several cardiovascular diseases (CVDs), including heart failure (HF). circRNAs can bind microRNAs (miRNAs), acting as competing endogenous RNAs (ceRNA), thus regulating the expression levels of miRNA target mRNAs. However, these …
-
Elucidating the regulation and function of circRNAs
Circular RNAs (circRNAs) are a newly appreciated class of RNAs that are expressed in a wide range of organisms, tissues, and disease states. The factors regulating circRNA biogenesis are poorly understood. CircRNAs are typically produced from exons of protein-coding genes through a process termed …
-
Design, Construction, and Screening of an shRNA Library Targeting Human Circular RNAs
… identified a large class of non-polyadenylated RNA molecules. Further, analysis of these RNAs revealed several unexpected junctions, which do not map to mRNAs, leading to the discovery of circular RNAs (circRNAs). Unlike linear RNAs, circRNAs have no ends and are not sensitive to …