Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"circuit-tracing"”.
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Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models
… this dissertation, I describe the application of circuit neuroscience techniques to study diverse tumor-neuron circuitry. Previous studies discovered a direct synaptic input to glioma cells via glutamatergic neurons, although their locations and whether other neuronal types may project to glioma …
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Learning image segmentation and hierarchies by learning ultrametric distances
… of the complete connectivity of neural circuits has been quite impoverished due to our inability to image all the connections between all the neurons in biological network. Connectomics is an emerging field in neuroscience that aims to revolutionize our understanding of the function of …
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The development of novel methods for the targeting and manipulation of neural circuits in vivo
… (SiR) which enables the targeting of neural circuits without cytotoxicity. To expand the scope of SiR we further developed the technology in two directions: A) By incorporating the CRISPR/CAS9 gene-editing machinery into the SiR genome to successfully edit endogenous loci in vitro and in …
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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
… and adipose tissue, we first used retrograde circuit tracing approaches to anatomically characterize the locations of the sympathetic pre- and postganglionic neurons innervating both iWAT and BAT. Interestingly, we found little overlap between iWAT and BAT innervating pre-ganglionic neurons, …