Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"circadian period"”.
-
The role of drosophila protein kinase doubletime in circadian period determination, morning and evening oscillators and tauopathy
… to overexpress mutant and wild type forms of the circadian protein kinase DBT in order to address several basic questions about DBT's biological functions. Different dbt mutations either shorten or lengthen the circadian period, although they all possess lower kinase activity in vitro. Therefore, …
-
The role of TOR in regulation of Arabidopsis circadian oscillators
Plants possess internal circadian oscillators, containing a series of gene expression feedback loops. These oscillators enable plants to coordinate their biological processes with the light- dark cycles of the Earth. Arabidopsis circadian oscillators are entrained by internal and external cues, …
-
The roles of spartin in Drosophila circadian clock
… we noticed that spartin1 flies manifested long circadian period of ~ 27hr. These data suggested that SPARTIN might play a role in circadian clock system. In spartin1 flies, the levels of PERIOD (PER) and TIMELESS(TIM) protein were lower than those of control flies, w1118, during the night time …
-
Analysing the role of SAL1/PAP retrograde signalling within the circadian system of Arabidopsis thaliana
… have developed an internal timing mechanism, the circadian system, that serves to synchronise physiological and metabolic functions with daily, predictable cues such as dawn and dusk. This endogenous oscillator is comprised of biochemical and transcriptional rhythms that are entrained by …
-
Circadian Timekeeping of Body Temperature by the Mammalian Suprachiasmatic Nucleus
The circadian rhythm of body temperature (CRT) is a universal cue for entraining the peripheral clocks in mammals. The hypothalamic suprachiasmatic nucleus (SCN) is required for generating the ~24-hour rhythms of body temperature (Tb); however, the neural mechanism underlying this regulation …
-
Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
… as CG17282 in the flybase was identified as a circadian clock component that stimulates DBT’s circadian function. Here, we have used biochemical and structural approaches to characterize BDBT. We determined the x-ray crystal structure of BDBT and the analysis showed that it is a noncanonical …
-
Evaluating sleep and circadian rhythm disturbances and symptoms of impulsivity and inattention: Implications for adult attention-deficit/hyperactivity disorder
… evidence pointing to dysfunction of the circadian timing system in ADHD, and individual differences in human chronotype and diurnal preference have been linked with impulsivity and attention problems in adults. In the work presented here we examined associations between a later circadian …
-
Time of Day Influences on Gonadotropin Releasing Hormone Neurons
… of the timing cue remains ambiguous at best, but circadian input is suspected. My studies found that mouse GnRH neurons express period 2 (Per2) and brain muscle ARNT like protein (Bmal) with a circadian period, and thus likely run a functional molecular clock. Further, vasoactive intestinal …
-
Circadian Orchestration of the Cellular Proteome
Circadian rhythms are biological oscillations with a period length of roughly 24 hours. They confer an adaptive advantage as they enable the prediction of the regular environmental changes caused by the rotation of the Earth, and so they are highly conserved. Circadian coordination of biology is an …
-
Unravelling novel molecular targets for photobiomodulation in human hair follicle towards the development of more effective light-based therapies for hair growth
… a stabilizer of CRY1 protein that lengthens the circadian period, delayed HF anagen-catagen transition; while silencing of CRY1 induced premature catagen development accompanied by reduced cell proliferation. Silencing of CRY1 in the HF outer root sheath (ORS) cells in vitro caused downregulation …
-
Interlocking mechanisms regulating the circadian clock response to DNA damage
… time-keeping system that oscillates with a periodicity of about 24 h, namely the circadian clock, that help them adapt to daily environmental changes. Mammalian circadian rhythms are generated and maintained by transcription-translation feedback loops (TTFLs) and include post-translational …
-
Genetic Studies on the Circadian Clock in the Model Organism Drosophila Melanogaster
… the basic neural mechanism that regulates circadian behavior in Drosophila is known in quite some detail, several aspects of this biological process still remain to be elucidated. In this study a variety of genetic and molecular approaches was used to identify and characterize genes that …
-
Characterization of Transcriptional and Post-transcriptional Regulation of lin-42/Period During Post-embryonic Development of C. elegans
Period, which is broadly conserved in metazoans, regulates circadian timing of neurophysiology as well as cell fate specification. Studies in mouse and humans indicate that period functions as a tumor suppressor and controls adult stem cell differentiation. However, regulation of period function in …
-
Circadian modulation of the estrogen receptor alpha transcription
The circadian clock is a molecular mechanism that synchronizes physiological changes with environmental variations. Disruption of the circadian clock has been linked to increased risk in diseases and a number of disorders (e.g. jet lag, insomnia, and cancer). Period 2 (Per2), a circadian protein, …