Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"circadian gene expression"”.
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Mathematical Modeling of Circadian Gene Expression in Mammalian Cells
Circadian rhythms in mammals are self-sustained repeating activities driven by the circadian gene expression in cells, which is regulated at both transcriptional and posttranscriptional stages. In this work, we first used mathematical modeling to investigate the transcriptional regulation of …
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Secondary Level Screening of Chlamydomonas Reinhardtii Mutants Defective in Circadian Gene Expression
… the signal transduction chain mediating circadian clock control, this work focuses on the isolation of Chlamydomonas reinhardtii mutants which are defective in circadian gene expression. In a previous study, the reporter gene ARS2 encoding the arylsulfatase enzyme was fused to the …
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Integration of Light and Temperature in the Regulation of Circadian Gene Expression in Drosophila
… largely focused on light-dependent regulation of circadian clocks and their outputs. Although light is the strongest and best understood Zeitgeber for the circadian clock, temperature is also an important factor. This thesis aims to understand better the role of temperature on gene expression and …
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Metabolic Regulation of Circadian Timekeeping
Circadian rhythms are self-sustained endogenous biological oscillations with a period of approximately 24 hours. These rhythms are observed widely across kingdoms and at all levels of biological scale. Recent work has shown there to be circadian variation in metabolism, both at the organismal and …
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Quantitative characterisation of single-cell circadian rhythms in cyanobacteria Synechococcus elongatus
… in light caused by our planet’s rotation. Circadian (24-h) rhythms enable living systems to adapt to environmental cycles and anticipate the changes in their surroundings. To perform their functions, the clocks must be sensitive to the entraining cues and simultaneously resilient to …
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Single Molecule Resolution Study of Circadian Chromatin Dynamics Regulated by the Pioneer Transcription Factor CLOCK:BMAL1
The mammalian circadian clock is initiated by the heterodimeric transcription factor CLOCK: BMAL1, which binds to the DNA during the day and activates the transcription of Period (Per1, 2, 3) and Cryptochrome(Cry1, 2) that form a repressive complex and inhibit CLOCK:BMAL1 transcription activity at …
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Disturbo bipolare e cefalea a grappolo: identificazione di geni e pathway molecolari e loro potenziale coinvolgimento nella risposta alla terapia con sali di litio tramite analisi dei profili di espressione genome‐wide
… conditions affecting 1% and 1.5% of the general population, respectively. Albeit the pathogenesis has not yet been completely elucidated, family and twin studies have suggested a genetic basis for both disorders, with an estimated heritability of 80% for BD and up to 60% for CH. Though BD …
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The role of circadian rhythms in reproduction: development and fertility in the bmal1 null mouse.
Circadian rhythms are the endogenous cycling of hormones, activity patterns and gene expression that occur across 24 hours. Disruption of circadian rhythms has been associated with multiple health complications, including reduction of fertility. The bmal1 mouse provides an animal model for central …