Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"circadian clocks"”.
-
REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY ARYL HYDROCARBON RECEPTOR
… metabolic disorders and alteration of circadian rhythm. Furthermore, circadian clock disruption and metabolic dysfunction are integrally associated with each other. This study was designed to understand the mechanisms by which AhR contributes to regulation of circadian clocks, fat …
-
REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY SYNTHETIC AHR AGONIST BETA-NAPHTHOFLAVONE IN MICE
The circadian clock system is essential for mammals to adapt to environmental conditions such as light-dark cycles and to manage the optimal timing for cyclical physiological processes, including sleep-wakefulness, fasting-feeding and multiple aspects of metabolism. The circadian timing system is …
-
Exploring circadian rhythms, food intake, and their interactions in marine invertebrates
Circadian rhythms and energy metabolism are critical and interconnected components of animal physiology. Metabolic inputs like time of feeding modulate circadian clocks and behavioral and molecular rhythms. In turn, circadian clocks regulate metabolic processes, allowing animals to optimize energy …
-
Exploring circadian rhythms, food intake, and their interactions in marine invertebrates
Circadian rhythms and energy metabolism are critical and interconnected components of animal physiology. Metabolic inputs like time of feeding modulate circadian clocks and behavioral and molecular rhythms. In turn, circadian clocks regulate metabolic processes, allowing animals to optimize energy …
-
Protein localization during the cyanobacterial circadian cycle
Circadian clocks are ubiquitous throughout the living world. Of these circadian clocks, the simplest one is found in cyanobacteria - unicellular, photosynthetic marine organisms. Studies of the circadian clock of Synechococcus Elongatus PCC 7942 have shown that the circadian clock is independent of …
-
Investigation of the regulatory interactions and dynamics between the circadian clock and sigma factors in the cyanobacterium Synechococcus elongatus
Circadian clocks are biological pacemakers that oscillate with a circa 24 h period. Many organisms across different taxa have evolved circadian clocks, which allow the anticipation of daily events caused by the Earth’s rotation and provide an adaptive advantage. The molecular mechanisms underlying …
-
Spatiotemporal Regulation of the NADP(H) Phosphatase Nocturnin
… in the environment. At its core, the mammalian "circadian clock" is a molecular oscillator driven by a genetic transcription/translation feedback loop, which orchestrates the rhythmic expression of thousands of genes. An intimate link between circadian clocks and metabolism is established by the …
-
A Structural and Biochemical Analysis of the Drosophila Protein Period
<p>Circadian clocks regulate changes in behavior and physiology that occur with a period of approximately 24 hours and are based on negative feedback loops. The molecular components of circadian clocks are conserved among animals, and a key element in all such clocks is the protein Period (PER), a …
-
Circadian Organization of the Neuroendocrine System of an Adult Insect, Rhodnius Prolixus (STÄL) (HEMIPTERA)
Circadian clocks synchronize with external environmental cycles and regulate rhythms throughout the organism, creating an internal temporal organization of cellular and physiological processes. In the model insect Rhodnius prolixus the prothoracicotropic hormone (PTTH)-ecdysteroid axis is a central …
-
Circadian Timekeeping of Body Temperature by the Mammalian Suprachiasmatic Nucleus
The circadian rhythm of body temperature (CRT) is a universal cue for entraining the peripheral clocks in mammals. The hypothalamic suprachiasmatic nucleus (SCN) is required for generating the ~24-hour rhythms of body temperature (Tb); however, the neural mechanism underlying this regulation …
-
Architecture of the Mammalian Circadian Repressive Complex
… their physiology to the solar day. Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRY1/2 and PER1/2). To understand what drives periodicity within this clock, I took structural approaches with the …
-
Splicing The Clock Is Timeless: From Fruit Fly Behavior To Mammalian Retinal Degeneration
Circadian rhythms synchronize intrinsic cycles of physiology and behavior with diurnal environmental oscillations of light and temperature. Circadian transcription-translation feedback loops (TTFLs), in which the rhythmic expression of core clock proteins negatively regulates their own expression, …
-
The butterfly clock : illuminating the molecular mysteries of monarch migration
… they have pinpointed the sun compass, and the circadian clock that guides it, in the monarch brain. They have shown how the clock and compass might work together to allow the monarchs to find their way to Mexico. Their work has also uncovered some unexpected insights into the workings and …
-
Variations in Time-Dependent Mosquito-Host Interactions Across Aedes Species
Virtually all organisms exhibit circadian rhythms, this includes mosquitoes. Many aspects of their biology are under the control of their circadian clocks like their vision, olfaction, host-seeking, mating, oviposition, metabolism, locomotion, and more. However, how the circadian clock regulates …
-
Integration of Light and Temperature in the Regulation of Circadian Gene Expression in Drosophila
<p>Clocks are aligned to the environment via inputs from both daily light and temperature cycles. Previous molecular and behavioral studies in Drosophila have largely focused on light-dependent regulation of circadian clocks and their outputs. Although light is the strongest and best understood …
-
Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation
… in a diurnal fashion as regulated by the master circadian (daily) clock in the suprachiasmatic nuclei ( SCN). Signaling in this regard is at least partially responsible for entraining circadian clocks outside of the SCN. Just as shifts in glucocorticoid exposure are associated with metabolic …
-
Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism
Circadian rhythms are daily molecular oscillations within cells ranging from prokaryotes to humans. This rhythm is self sustaining, and receives external cues in order to synchronize an organism's behavior and physiology with the environment. Many metabolites utilized in metabolic processes seem to …
-
Genetic and Biochemical Studies on Protein Phosphorylation in the Circadian Clock of Drosophila Melanogaster
<p>Circadian rhythms in physiology and behavior are observed in almost all phyla. Genetically encoded internal clocks generate such rhythms. Identification of gene products required for the generation and maintenance of endogenous circadian near 24-hr rhythms has led to a paradigm of multiple …
-
Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
… by an intracellular timing system called the circadian clock. However, little is known about whether and how the day-night cycle and the circadian clock influence host immunity. Here, I show that the circadian transcription factor NFIL3 is critical for both adaptive and innate immunity by …