Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 132 for “"circadian clock"”.
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Roles of AMPK in Drosophila circadian clock
국문요약 ⅰ 차례 ⅳ 그림 차례 ⅵ 표 차례 ⅶ Ⅰ. 서론 1 Ⅱ. 재료 및 방법 5 A. Schneider 2 (S2) 세포에서 발현시키기 위한 plasmid 5 B. S2 세포의 배양과 transfection 6 C. 형질전환 초파리 6 D. Locomotor Activity Monitoring System 8 E. 초파리 entrainment와 수확 8 F. 단백질액 추출 (lysis) 9 1. S2 세포에서 단백질액 추출 9 2. 초파리 머리에서 단백질액 추출 9 G. Immunoblotting (western …
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Cholinergic regulation of a mammalian circadian clock
… carbachol, has been shown to shift the phase of circadian rhythms in rodents when injected intracerebroventricularly. However, the site and receptor type mediating this action have been unknown. The suprachiasmatic nuclei (SCN), the primary circadian pacemaker in mammals, continue to show a …
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Coordination of the Arabidopsis thaliana circadian clock
… plant cells have a genetic circuit, the circadian clock, that times key processes to the day-night cycle. These clocks are aligned to the day-night cycle by multiple environmental signals that vary across the plant. Thus, the clock may be set separately in cells creating discrepancies in …
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The roles of spartin in Drosophila circadian clock
… we noticed that spartin1 flies manifested long circadian period of ~ 27hr. These data suggested that SPARTIN might play a role in circadian clock system. In spartin1 flies, the levels of PERIOD (PER) and TIMELESS(TIM) protein were lower than those of control flies, w1118, during the night time …
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Conservation of Timeless in the Mammalian Circadian Clock
… negative feedback arm of the mammalian molecular clockwork. This models supports conservation of transcriptional elements that are the basis for the molecular generation of circadian rhythms.
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Histone modifications and the Arabidopsis thaliana circadian clock
The circadian system has a regulatory role in almost all aspects of a plant's life. In Arabidopsis thaliana, almost 36% of the genome has been shown to be circadianly regulated and many genes that are circadianly regulated have been shown to be light responsive or involved in light responses. …
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Functional investigation of PERIOD in the mammalian circadian clock
Circadian rhythms are cell-autonomous biological oscillations with a period of approximately 24 hours. They are observed across all kingdoms of life and allow the organisation of physiology to anticipate and accommodate the different environmental and energetic demands of day and night. In human …
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Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism
Circadian rhythms are daily molecular oscillations within cells ranging from prokaryotes to humans. This rhythm is self sustaining, and receives external cues in order to synchronize an organism's behavior and physiology with the environment. Many metabolites utilized in metabolic processes seem to …
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Alternative splicing in the regulation of the barley circadian clock
… expression. The novel work on AS in Arabidopsis clock genes coincided with availability of the barley genome sequence and the rest of my PhD was spent in examining AS in the circadian clock of barley.<br/> Prior to this thesis, extensive alternative splicing (AS) was shown to regulate clock genes …
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Modeling the interactions between the circadian clock, dopamine, and metabolism
… biology: (1) Mathematical modeling of the circadian clock and dopamine, (2) Mathematical analysis of a circadian clock model, and (3) Mathematical modeling of sex differences in one-carbon metabolism. Circadian rhythms, dopamine, and metabolism are all important aspects of human physiology …
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Interlocking mechanisms regulating the circadian clock response to DNA damage
… with a periodicity of about 24 h, namely the circadian clock, that help them adapt to daily environmental changes. Mammalian circadian rhythms are generated and maintained by transcription-translation feedback loops (TTFLs) and include post-translational modifications to help fine-tune the …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
<p>The mammalian circadian clock responds to the 24-hour daily cycle and regulates tissue-specific gene expression and downstream physiology. The central pacemaker located in the hypothalamic suprachiasmatic nuclei (SCN) synchronizes the peripheral clocks in different tissues. This dissertation …
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Chronic Circadian Misalignment Disrupts the Circadian Clock and Promotes Metabolic Syndrome
… Chronic misalignment of an organism’s internal circadian clock with diurnal, cyclic changes in the external environment, prevalent in professions that require shift work, contributes significantly to Type 2 Diabetes development. Experimentally, only short-term models of circadian disruption have …
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Pituitary Adenylate Cyclase -Activating Peptide Signaling in the Mouse Circadian Clock
… light/glutamate-induced phase resetting of the circadian clock, yet the particulars of this role remain controversial. Mice generated by Lee Eiden and colleagues that do not express PACAP were examined to test the hypothesis that PACAP plays a physiological role in light or glutamate-induced …
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The interdependent regulation of photosynthesis and the circadian clock in wheat
The circadian clock is an endogenous timing mechanism that allows organisms to coordinate physical and behavioural processes with the natural light dark cycle. Synchronisation between the circadian clock and environment in plants provides a fitness advantage (Dodd et al. 2005) and in wheat several …
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Genetic Studies on the Circadian Clock in the Model Organism Drosophila Melanogaster
… the basic neural mechanism that regulates circadian behavior in Drosophila is known in quite some detail, several aspects of this biological process still remain to be elucidated. In this study a variety of genetic and molecular approaches was used to identify and characterize genes that …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
Circadian rhythms are recurring patterns in behavioural, physiological, and other parameters that display periods of approximately every twenty four hours. The molecular basis of the circadian timekeeping involves clock genes which act as transcription factors in a serious of feedback loops. …
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Investigating the role of the circadian clock in the physiology of wheat
The circadian clock is an endogenous timing mechanism which acts to synchronise internal processes with daily and seasonal cycles in light and temperature. In Arabidopsis, the components which comprise the circadian oscillator and output pathways are well defined. Photoperiod dependent flowering, …
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The Role of SOX2 in Molecular Circadian Clock Regulation and Suprachiasmatic Nucleus Development
… (SCN), that contains the mammalian central circadian clock. The 20,000 clock neurons in the SCN are responsible for interpreting photic signals and orchestrating oscillations in peripheral tissues. In this study, I demonstrated the “unusual” and “non-canonical” roles of Sox2 in these …
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