Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"circRNAs"”.
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Elucidating the regulation and function of circRNAs
Circular RNAs (circRNAs) are a newly appreciated class of RNAs that are expressed in a wide range of organisms, tissues, and disease states. The factors regulating circRNA biogenesis are poorly understood. CircRNAs are typically produced from exons of protein-coding genes through a process termed …
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Design, Construction, and Screening of an shRNA Library Targeting Human Circular RNAs
… leading to the discovery of circular RNAs (circRNAs). Unlike linear RNAs, circRNAs have no ends and are not sensitive to exoribonucleases, endowing circRNAs with a longer half-life. This enhanced stability has prompted the study of circRNAs as cancer biomarkers. While expression studies are …
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A Tale of RNA Circles: Function of Circular RNAs in Reproduction
CircRNAs are a group of RNA circles harboring exons out of order from their normal genomic contexts. Although discovered ~20 years ago, circRNAs have since then been overlooked because they were regarded as "transcriptional noises" without specific functions. CircRNAs have returned to the spotlight …
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ROLE OF CIRCULAR PVT1 IN ISCHEMIC HEART FAILURE
Circular RNAs (circRNAs) are involved in the pathogenesis of several cardiovascular diseases (CVDs), including heart failure (HF). circRNAs can bind microRNAs (miRNAs), acting as competing endogenous RNAs (ceRNA), thus regulating the expression levels of miRNA target mRNAs. However, these …
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Site-specific chemical and topological modifications to augment mRNA therapeutic potential
… translation initiation on circular mRNAs (circRNAs). We developed QRNAs, which are circRNAs that possess an unnaturally-linked inverted 7-methylguanosine (m7G) cap. QRNAs substantially outperform conventional circRNAs, given the low translation initiation efficiency of IRES compared to …
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LncRNA and circRNA expression profiles in tissues and serum exosomes of colorectal cancer patients and cell lines
… non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), which seem to act through a plethora of molecular mechanisms regulating essential biological processes, such as cell cycle, splicing, chromatin remodeling, apoptosis, adhesion and migration. LncRNAs are non-coding RNAs longer than 200 …
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Análisis de variabilidad de secuencia in vivo de RNAs circulares con ribozimas
… ventaja adaptativa o edición específica de los circRNAs que las contienen. Además, se ha demostrado que la variabilidad en retrozimas mutados que dan lugar a RNA lineales es mínima comparada con la observada en los retrozimas con circRNAs. La posible función específica de estas variantes …
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CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS
… induced neuroadaptations. We identified 76 circRNAs regulated by heroin self-administration, of these we selected circGrin2b_011731 (circGrin2b) for further characterization. circGrin2b is derived from exon 3 of linear Grin2b, which encodes the regulatory subunit of the NMDA receptor, …
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Implementation of circFISH to quantify the expression and cellular localization of circNFIX in cerebral palsy
… non`-coding RNAs called circular RNAs (circRNAs) have been studied to play important roles in different physiological processes and dysregulation of circRNAs have been associated with different cancers and many other pathologies. Recently circNFIX has been observed to be a regulatory …
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The Investigation of the SKA3 Circular RNA Role in the Ovarian Cancer Progression
Circular RNAs (circRNAs) are becoming increasingly more recognized in cancer biology as novel biomarkers due to their high stability as well as tissue- and developmental stage-specific expression. Despite massive improvements made in treatments, ovarian cancer (OC) still is considered one of the …
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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
… oligonucleotides (ASOs), circular RNAs (circRNAs), and aptamers. Despite their significant potential, these therapeutics face important limitations, including susceptibility to RNase degradation, high net negative charge, and rapid renal clearance. To address these challenges, advanced …
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THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… RNA and removal of linear RNA. We identified circRNAs differentially expressed in pro-and anti-inflammatory macrophages, including circRNA cdr1as (circ-cdr1as). RT-qPCR analysis revealed circ-cdr1as was one of the most downregulated in pro-inflammatory macrophages and significantly upregulated …
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Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an aberrant expansion of CAG repeats within the HTT gene, for which there is currently no cure. The disease is driven by the mutant huntingtin protein, which predominantly leads to the degeneration of the striatum …