Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"circRNA"”.
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LncRNA and circRNA expression profiles in tissues and serum exosomes of colorectal cancer patients and cell lines
… non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), which seem to act through a plethora of molecular mechanisms regulating essential biological processes, such as cell cycle, splicing, chromatin remodeling, apoptosis, adhesion and migration. LncRNAs are non-coding RNAs longer than 200 …
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Elucidating the regulation and function of circRNAs
Circular RNAs (circRNAs) are a newly appreciated class of RNAs that are expressed in a wide range of organisms, tissues, and disease states. The factors regulating circRNA biogenesis are poorly understood. CircRNAs are typically produced from exons of protein-coding genes through a process termed …
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A Tale of RNA Circles: Function of Circular RNAs in Reproduction
CircRNAs are a group of RNA circles harboring exons out of order from their normal genomic contexts. Although discovered ~20 years ago, circRNAs have since then been overlooked because they were regarded as "transcriptional noises" without specific functions. CircRNAs have returned to the spotlight …
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Synthetic circular RNA for protein expression
… degradation upon delivery. Circular RNA (circRNA), a type of single-stranded RNA with a contiguous structure that lacks the end motifs necessary for exonuclease recognition, may be resistant to this mechanism of degradation and therefore may exhibit superior stability. However, challenges …
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CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS
… this dissertation we will examine circular RNA (circRNA) dysregulation following a rodent model of heroin self-administration and characterize a novel circRNA pathway regulating opioid induced neuroadaptations. We identified 76 circRNAs regulated by heroin self-administration, of these we …
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ROLE OF CIRCULAR PVT1 IN ISCHEMIC HEART FAILURE
Circular RNAs (circRNAs) are involved in the pathogenesis of several cardiovascular diseases (CVDs), including heart failure (HF). circRNAs can bind microRNAs (miRNAs), acting as competing endogenous RNAs (ceRNA), thus regulating the expression levels of miRNA target mRNAs. However, these …
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The Investigation of the SKA3 Circular RNA Role in the Ovarian Cancer Progression
Circular RNAs (circRNAs) are becoming increasingly more recognized in cancer biology as novel biomarkers due to their high stability as well as tissue- and developmental stage-specific expression. Despite massive improvements made in treatments, ovarian cancer (OC) still is considered one of the …
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Design, Construction, and Screening of an shRNA Library Targeting Human Circular RNAs
… leading to the discovery of circular RNAs (circRNAs). Unlike linear RNAs, circRNAs have no ends and are not sensitive to exoribonucleases, endowing circRNAs with a longer half-life. This enhanced stability has prompted the study of circRNAs as cancer biomarkers. While expression studies are …
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Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension
… of alternative BMPR2-derived circular RNAs (circRNA) to these processes remain unexplored. This study explored the hypothesis that endothelial BMPR2 loss alters the structures of organelles central to trafficking and cytoskeletal assembly dynamics, resulting in impaired intracellular …
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Análisis de variabilidad de secuencia in vivo de RNAs circulares con ribozimas
… ventaja adaptativa o edición específica de los circRNAs que las contienen. Además, se ha demostrado que la variabilidad en retrozimas mutados que dan lugar a RNA lineales es mínima comparada con la observada en los retrozimas con circRNAs. La posible función específica de estas variantes …
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THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… RNA and removal of linear RNA. We identified circRNAs differentially expressed in pro-and anti-inflammatory macrophages, including circRNA cdr1as (circ-cdr1as). RT-qPCR analysis revealed circ-cdr1as was one of the most downregulated in pro-inflammatory macrophages and significantly upregulated …