Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"ciliogenesis"”.
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Regulation and function of genes involved in drosophila ciliogenesis
… These defects were linked to a disruption in the ciliogenesis machinery, particularly in the process known as intraflagellar transport (IFT). dila mutants also display reduced male fertility because of aberrant basal body function, which leads to a disorder in sperm individualisation. Thus DILA is …
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Identifying The Roles of miR-17 in Ciliogenesis and Cell Cycle
<p>Emerging evidence suggests a significant contribution of primary cilia to cell division and proliferation mechanisms. MicroRNAs, especially miR-17, contribute to cell cycle regulation and proliferation. Recent investigations have highlighted the dysregulated expression of miR-17 in various …
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Computational Methods for Accelerated Discovery and Characterization of Genes in Emerging Model Organisms
… whole-gene annotations but in which the ciliogenesis process can be reliably induced. Experimental methods have been successful in identifying a handful of highly specific cilia disease genes in the alga, but high-throughput, automated computational analyses harbor the greatest potential …
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Protein-Protein Interactions in Cell Cycle Proteins: An <i>In silico</i> Investigation of Two Important Players
… NEK family of proteins. NEK10 participates in ciliogenesis, DNA Damage Repair (DDR), and mitochondrial homeostasis. Studies show NEK10’s participation in various disorders, such bronchiectasis syndrome, breast cancer, and lung cancer. However, NEK10 is largely understudied. To address the lack …
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The Role of Daam1 In Kidney Development
… We also report divergent roles for Daam1 in ciliogenesis. This dissertation enhances our understanding of cytoskeletal regulation, adhesion, and organizational behaviors involved in nephron assembly.</p>
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The Role of Daam1 In Kidney Development
… We also report divergent roles for Daam1 in ciliogenesis. This dissertation enhances our understanding of cytoskeletal regulation, adhesion, and organizational behaviors involved in nephron assembly.</p>
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A Novel Collapsing Response Mediator Protein 2 Binding Domain for Kinesin Light Chain 3
… Response Mediator Protein 2 is required for ciliogenesis, localizes to the basal body, and can be transported into the primary cilium, however, the involved mechanism is not clear, but was proposed to involve kinesin proteins. KLC3 is the only known kinesin light chain expressed in elongating …
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Mutation of Polaris, an Intraflagellar Transport Protein, Shortens Neuronal Cilia
… day 14. These data suggests that even after ciliogenesis, intraflagellar transport is necessary in order to maintain neuronal cilia. Regional heterogeneity in the effect of this gene mutation on neuronal cilia suggests that the functions of some brain regions might be more compromised than …
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INVESTIGATION OF THE DISTAL APPENDAGE PROTEIN CEP164 IN Trypanosoma brucei
… of the Cep164 protein to carry out docking and ciliogenesis. Understanding of basal body docking and flagellum length regulation in the Trypanosoma brucei cell is limited and is thought to involve the transitional fibres and surrounding structures. Three diverse Cep164 orthologues in the T. …
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The role of CD133 in mouse incisor tooth epithelium
… Hdac6 to the primary cilium regulating proper ciliogenesis. Establishment of an in vitro cell culture model of dental epithelial cells allowed the investigation of nuclear CD133 under normal physiological conditions. To date, nuclear CD133 has been reported in a variety of cancers. This study …
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Towards the understanding of pericentriolar satellite biology
… centrosome components, and they are involved in ciliogenesis and stress response. Moreover, several proteins that localize to PS are mutated in human ciliopathies and neurodevelopmental disorders. The precise roles of PS in the various molecular pathways and diseases are however poorly …
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Identification of TbRP2-interacting proteins using proximity-dependent biotinylation (BioID)
… containing protein with important roles in ciliogenesis. In humans, mutations in the RP2 gene are associated with 10-15% of cases of X-linked retinitis pigmentosa; a devastating disease characterised by progressive degeneration of retinal photoreceptors. Although XRP2 was initially proposed …
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Transient CaMK-II Activation is Necessary for Left-Right Asymmetry in the Zebrafish Embryo
… suggesting a role for CaMK-II in the process of ciliogenesis. CaMK-II is a binding partner of Kif2C, a Kinesin 13 member. Kinesin 13 members control flagellar length in Chlamydomonas, the blue-green algae and protists. The roles of Kif2C in zebrafish have never been explored, but could …
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
… therefore propose that these profound defects in ciliogenesis may be driven by dysregulated mitochondrial function. This was highlighted by the fact that the airway epithelium of p73 null mice displayed downregulation of OPA1 and an altered morphology of the mitochondrial network in the ciliated …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… kinase activity is required for RAB8-mediated ciliogenesis and ciliary localization of the insulin receptor. Interestingly, inhibition of LRRK2 kinase activity leads to failure of these mechanisms and disruption of myoblasts-myotubes differentiation process. Collectively, these data point to …
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Enteric and hepatic glia-like cell reactivation after astrocyte-directed twinkle helicase loss
… spongiotic encephalopathy, astrogliosis and ciliogenesis activation in the mouse brain. This model is created by using a glial fibrillary acid (GFAP) promoter, driving a Cre recombinase that together with LoxP sequences leads to a knockout of the twinkle gene in the cells expressing GFAP. In …
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Function of the forkhead gene fd3F in Drosophila chordotonal neuron differentiation
Drosophila chordotonal (Ch) organs are internal stretch receptors required for coordination, balance and hearing. The outer dendritic segment of the Ch neuron is a compartmentalised motile cilium, a feature that is exclusive to this neuron subtype. Ch organs are specified early in development by …
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Role of WDR35 in the formation of functional cilia
… to cilioplasm. Biogenesis of the cilium (ciliogenesis) requires many carriers and adaptors to facilitate passage of cargo across the transition zone. Once inside the cilia intraflagellar transport (IFT) proteins move the cargo along microtubules ‘railways’ of the axoneme. IFTs are known to …
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Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
… members of the TRAPP complex implicated in ciliogenesis and Usp30, involved in mitophagy and pexophagy. A further 4 genes were identified as increasing the lytic capacity of CTL and included: Arpc1b, involved in actin filament branching; Bach2, a transcriptional regulator; Lrrc8d, a …
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Structural characterization of primary cilia using accelerated piezoelectrically driven STED nanoscopy
… primary cilia that plays a significant role in ciliogenesis and in maintaining structural integrity of primary cilia. Our data provides the first visualization of two important transition zone members, Tctn-2 and Cep290. We were able to demonstrate structural detail heretofore impenetrable to …
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